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Kocagoz Tanil Can Ozge Yurttutan Uyar Neval Aksoy Ece Polat Tuba Cankaya Dilara Karakus Betul Mozioglu Erkan Kocagoz Sesin 《European journal of clinical microbiology & infectious diseases》2021,40(12):2617-2622
European Journal of Clinical Microbiology & Infectious Diseases - Since its emergence in December 2019, SARS-CoV-2 is causing one of the most devastating pandemics in human history. Currently,... 相似文献
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Yurttutan S Ozdemir R Erdeve O Calisici E Oncel MY Oguz SS Dilmen U 《Acta haematologica》2012,127(3):189-192
Intrauterine ischemia of the limbs is a rare condition involving thrombosis and ischemia of the extremities before birth. The clinical presentation depends on the extremity affected as well as the timing of thrombosis. Very few cases with extremity hypoperfusion and gangrene due to intrauterine thrombosis have been reported in the literature, and therefore there is no consensus on the optimal therapeutic strategy for such cases. Presented here is a case of a newborn with intrauterine brachial arterial thrombosis of the right upper extremity who was successfully treated by a combination of recombinant tissue plasminogen activator, enoxaparin and collagenase application followed by surgery. 相似文献
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Mehmet Yekta Oncel Sadik Yurttutan Evrim Alyamac Dizdar Ismail Kursat Gokce Ipek Isik Gonul Turgut Topal 《Journal of investigative surgery》2016,29(1):1-5
Purpose: To determine whether prophylaxis with etanercept, an anti-inflammatory drug, would decrease the severity of lung injury in a neonatal rat model of bronchopulmonary dysplasia (BPD); Materials and Methods: Rat pups were divided into three groups: pups exposed to room air (group 1; n = 10), to hyperoxia + placebo (group 2; n = 9), and to hyperoxia + etanercept (group 3; n = 8). Lung morphology was assessed by alveolar surface area percentage, which is a measure of alveolar size. The severities of lung inflammation and antioxidant capacity were assessed by quantifying tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), malondialdehyde (MDA), and superoxide dismutase (SOD) from lung homogenate; Results: The percentage of alveolar surface areas were significantly higher in group 3 compared to group 2 (p = .004) and similar in both group 1 and group 3 (p = .21). The mean level of lung MDA was significantly higher in group 2 compared to group 1 and group 3 (p < .05 for both). Lung homogenate SOD activities in group 3 was significantly higher than group 2 (p < .001). Furthermore, group 3 pups had lower levels of TNF-α and TGF-β in lung homogenate than that in group 2 (p < .05 for both) but similar in both group 1 and group 3; Conclusion: Etanercept has favorable effects on alveolarization as well as inflammation and oxidative stress markers in a neonatal rat model of BPD. 相似文献
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Sadık Yurttutan Ramazan Ozdemir Fuat Emre Canpolat Mehmet Yekta Oncel Hatice Germen Unverdi Bülent Uysal Ömer Erdeve Ugur Dilmen 《Pediatric surgery international》2014,30(1):71-77
Purpose
Tissue damage in necrotizing enterocolitis (NEC) of infants occurs as a result of an uncontrolled inflammatory response. The aim of this study was to investigate any potential anti-inflammatory effects that Etanercept may have on the inflammatory response in an experimental NEC model in newborn rats.Methods
Newborn pups were randomized into three groups immediately after birth (Control, NEC + Placebo and NEC + Etanercept). Pups in the NEC + Placebo and NEC + Etanercept groups were subjected to an NEC-inducing protocol (hypercarbia, hypothermia and hyperoxia) twice a day for 3 days. Pups in the NEC + Etanercept group were given an intraperitoneal injection of Etanercept. Rats were harvested for biochemical and histopathological examinations.Results
The histopathological injury score of rats in the NEC + Placebo group was significantly higher compared to the NEC + Etanercept and Control groups (p < 0.05 for both comparisons). Tissue levels of tumor necrosis factor-α, interleukin-1β, and malondialdehyde were higher in the placebo group compared to the Etanercept group.Conclusion
Our results suggest that Etanercept attenuates intestinal tissue damage in NEC by reducing inflammation and blocking the production of free-oxygen radicals, while also reducing tissue levels of tumor necrosis factor-α and interleukin-1β. 相似文献5.
Sadık Yurttutan Aydın Bozkaya Füheda Hüdayioglu Mehmet Yekta Oncel 《The journal of maternal-fetal & neonatal medicine》2019,32(21):3662-3665
Objective: Hemodynamically significant PDA (hsPDA) is one of the most common problems in preterm infants. This study was conducted to investigate the effect of combined pharmacological (paracetamol?+?ibuprofen) therapy on monotherapy-resistant hsPDA in infants.Subject and methods: The study included infants with persistent hsPDA, unresponsive to monotherapy. Combined treatment (paracetamol?+?ibuprofen) was started as paracetamol at a dose of 15?mg/kg every 6?hours for 5?days, and ibuprofen at an initial dose of 10?mg/kg followed by 5?mg/kg at 24 and 48?hours. Echocardiographic evaluation was performed at 2?days after the end of treatment. If hsPDA persisted after the combined treatment, a surgical PDA ligation was considered.Results: A total of 12 infants were enrolled and 9 infants (75%) with monotherapy-resistant PDA were successfully treated with combined therapy. In three patients, no response was obtained to the combined treatment so surgical ligation was applied.Conclusions: Combined therapy may be a useful treatment option for monotherapy-resistant hsPDA in preterm infants. Before surgical ligations, this combined therapy option should be considered. 相似文献
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Objectives
The objective of this study was to determine whether use of a longer (1 in.) rather than a standard (5/8 in.) needle used for macrosomic neonates (birthweight over 4000 g) may affect antibody titers after immunization against hepatitis B virus (HBV).Methods
Fifty nine healthy infants were vaccinated at birth, 1, and 6 months of age with hepatitis B vaccine, with follow up to 7 months of age. Infants were randomized into two groups according to needle length of first vaccine at birth. First group vaccinated with standart needle length and other group received vaccine by longer needle length.Results
Macrosomic infants who were immunized with a longer needle achieved significantly higher antibody titers to hepatitis B surface antigen than standart needle length (median, 3890.2 vs 1311.7 mIU/mL, respectively; p = 0.001).Conclusions
Macrosomic neonates benefit from longer needle length with higher levels of antibody titers after HBV vaccination. 相似文献8.
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Letter in response to Maderna E et al,Measles Inclusion‐Body Encephalitis: Neuronal Phosphorylated Tau Protein Is Present in the Biopsy but Not in the Autoptic Specimens of the Same Patient,Brain Pathology,doi: 10.1111/bpa.12332
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