全文获取类型
收费全文 | 7554篇 |
免费 | 442篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 99篇 |
儿科学 | 167篇 |
妇产科学 | 112篇 |
基础医学 | 857篇 |
口腔科学 | 175篇 |
临床医学 | 587篇 |
内科学 | 1845篇 |
皮肤病学 | 171篇 |
神经病学 | 613篇 |
特种医学 | 276篇 |
外科学 | 1284篇 |
综合类 | 33篇 |
预防医学 | 282篇 |
眼科学 | 130篇 |
药学 | 625篇 |
中国医学 | 20篇 |
肿瘤学 | 765篇 |
出版年
2023年 | 53篇 |
2022年 | 97篇 |
2021年 | 198篇 |
2020年 | 105篇 |
2019年 | 173篇 |
2018年 | 195篇 |
2017年 | 156篇 |
2016年 | 160篇 |
2015年 | 192篇 |
2014年 | 236篇 |
2013年 | 270篇 |
2012年 | 467篇 |
2011年 | 504篇 |
2010年 | 271篇 |
2009年 | 214篇 |
2008年 | 411篇 |
2007年 | 451篇 |
2006年 | 393篇 |
2005年 | 420篇 |
2004年 | 432篇 |
2003年 | 393篇 |
2002年 | 338篇 |
2001年 | 212篇 |
2000年 | 211篇 |
1999年 | 164篇 |
1998年 | 75篇 |
1997年 | 61篇 |
1996年 | 63篇 |
1995年 | 61篇 |
1994年 | 37篇 |
1993年 | 35篇 |
1992年 | 71篇 |
1991年 | 82篇 |
1990年 | 72篇 |
1989年 | 90篇 |
1988年 | 79篇 |
1987年 | 76篇 |
1986年 | 62篇 |
1985年 | 57篇 |
1984年 | 36篇 |
1983年 | 40篇 |
1982年 | 21篇 |
1981年 | 17篇 |
1979年 | 41篇 |
1978年 | 27篇 |
1977年 | 33篇 |
1974年 | 21篇 |
1973年 | 22篇 |
1972年 | 23篇 |
1971年 | 22篇 |
排序方式: 共有8041条查询结果,搜索用时 15 毫秒
1.
Takako Miyamae Masaaki Mori Yasuji Inamo Youichi Kohno Shuji Takei Motoharu Maeda Takuji Murata Shuji Nakata Hiroshi Kawai Yukiko Hirano Yukiji Date Katsuhiko Kitamura Shumpei Yokota 《Ryūmachi》2003,43(3):538-543
OBJECTIVES: To reveal the frequency and the clinical characteristics of dystrophic calcification that occurs in children with juvenile dermatomyositis, multi-center analysis was constructed. METHOD: Fifty children with JDM were enrolled, and 14 of them (28.0%) were complicated with calcinosis. Clinical symptoms and laboratory tests at onset, initial therapy and disease course were compared in children with and without calcinosis. RESULTS: The mean age of the onset of calcinosis was 4.78 +/- 3.33 years, and it was younger than those of children without calcinosis (8.66 +/- 3.85 years) (P = 0.0017). No differences of clinical manifestation except Gower's sign were observed. The frequency of positive anti-nuclear antibody was 7.1% in children with calcinosis and 52.9% without calcinosis (P = 0.0112). The initial therapy of methylprednisolon pulses gave no effects on prognosis of calcium deposition. The calcinosis appeared in 1.56 +/- 1.91 year after the onset of the disease. The various types of calcium deposition including large tumorous clumps, subcutaneous plaques or nodules, sheet-type calcification were deserved. They appeared over knee joints (64.3%), elbow joint (64.3%), and hip processes (50.0%). Calcinosis affecting the subcutaneous tissues frequently resulted in painful superficial ulceration of the overlying skin (42.9%), local infection (50.0%), and limitation of joint movement (14.3%). Although aluminum phosphate was effective in 2 children among 7, no other effective treatment was recommended. In 5 cases, surgical removal of tumorous clumps was operated. Thus, juvenile dermatomyositis is frequently complicated with calcinosis. This type of calcinosis was found to be unlikely to resolve completely, and resulted in severe disability in children. 相似文献
2.
Yukiko Kaizu Sakae Ohkawa Hiromichi Kumagai 《Nephrology, dialysis, transplantation》2002,17(3):442-448
BACKGROUND: Measurement of muscle mass is useful for evaluating protein nutritional status. Various methods for estimating muscle mass in haemodialysis patients have recently been developed. METHODS: The validity of the estimate of creatinine production calculated with the creatinine kinetic model (CKM) was examined in 46 haemodialysis patients by comparing it with the actual creatinine production, this being determined from the sum of creatinine appearing in the dialysate and the estimated metabolic degradation. The correlation of various other muscle mass indices with creatinine production was also investigated in these patients. RESULTS: The estimate of creatinine production using CKM was significantly correlated with creatinine production calculated from the spent dialysate plus an estimate for the extra-renal creatinine degradation (r=0.90, P<0.001). A Bland-Altman analysis revealed that the mean prediction error for the estimate of creatinine production by CKM was +0.10 g/day and the limits of agreement were +0.34 to -0.14 g/day. The cross-sectional area of the thigh muscle measured by computed tomography (CT) was also significantly correlated with creatinine production (r=-0.86, P<0.01). In contrast, the correlations of 3-methylhistidine production measured in the spent dialysate, the mid-upper arm muscle circumference and the skeletal muscle mass estimated by an anthropometric prediction model with creatinine production were lower (r<0.82). CONCLUSION: Creatinine production calculated using CKM and CT measurement of thigh muscle area are valid methods for estimating muscle mass during routine clinical examinations of haemodialysis patients. 相似文献
3.
S Kawata S Noda Y Imai S Tamura R Saitoh S Miyoshi Y Minami S Tarui 《Gastroenterologia Japonica》1987,22(1):55-62
The pharmacokinetics of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) and its conversion into 5-fluorouracil (FUra) in liver tissue were studied in ten patients with hepatocellular carcinoma (HCC). The plasma concentration of FT after its intravenous injection (dosage: 800 mg) was computerfitted to a bi-exponential function (C = Ae-alpha t + Be-beta t), indicating a two-compartment disposition. The pharmacokinetic parameters did not significantly differ between the five patients with, and the five without cirrhosis of the liver. The plasma concentrations of FUra likewise showed no significant difference between the two groups. The rates of FT degradation in the liver tissue homogenate were similar for four of the patients with cirrhosis (0.10 +/- 0.05 mumol/g liver protein/30 min) and four of those without it (0.13 +/- 0.05). The rates of cytochrome P-450-dependent FUra formation in the microsomal fraction of liver tissue from two patients (1.1 and 1.3 nmol/mg microsomal protein/30 min) were dramatically reduced to less than half of those of two control subjects (2.4 and 2.7). The estimated rates of FUra formation in the soluble fraction (105,000 X g supernatant fraction) from the two patients (0.1 and 0.13 nmol/mg protein/30 min) were almost identical to those from the controls (0.12 and 0.14), suggesting that the rate in the soluble fraction from HCC patients may not be as strongly affected as the rate in the microsomal fraction.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
4.
Hidero Minami Ryo Matsutani Atsushi Mizokami Mikio Namiki 《International journal of urology》2007,14(4):368-369
Abstract: A 19-year-old woman presented at our hospital with acute urinary retention in September 2005. She had experienced the same chief complaint twice previously. She had used non-steroidal anti-inflammatory drugs before acute urinary retention. The results of physical examinations were unremarkable, and her neurologic signs were not remarkable. The basic laboratory test values were all normal and a psychiatric assessment indicated that her symptoms were not psychogenic. Magnetic resonance imaging was carried out, but revealed only a slight bulging in the L3/L4/L5 disk. Water cystometry showed acontractile detrusor. We made a diagnosis of acute urinary retention as a result of non-steroidal anti-inflammatory drugs because of her use of such drugs before the development of symptoms on multiple occasions. This patient was regularly followed up as an outpatient, and she could void smoothly in February 2006. This is the first report which acute urinary retention associated with non-steroidal anti-inflammatory drugs in Japan. 相似文献
5.
6.
Yu-Yan Fan Ryoko Baba Yukiko Nagai Akira Miyatake Naohisa Hosomi Shoji Kimura Guang-Ping Sun Masakazu Kohno Mamoru Fujita Youichi Abe Akira Nishiyama 《Hypertension research》2006,29(3):169-178
Recent studies have suggested that aldosterone plays a role in the pathogenesis of renal injury. In this study, we investigated whether local angiotensin II (Ang II) activity contributes to the progression of renal injury in aldosterone/salt-induced hypertensive rats. Uninephrectomized rats were treated with 1% NaCl in a drinking solution and one of the following combinations for 6 weeks: vehicle (2% ethanol, s.c.; n=9), aldosterone (0.75 mug/h, s.c.; n=8), aldosterone+Ang II type 1 receptor blocker olmesartan (10 mg/kg/day, p.o.; n=8), or aldosterone+olmesartan (100 mg/kg/day, p.o.; n=9). Aldosterone/salt-treated hypertensive rats exhibited severe proteinuria and renal injury characterized by glomerular sclerosis and tubulointerstitial fibrosis. Aldosterone/salt-induced renal injury was associated with augmented expression of angiotensin converting enzyme and Ang II levels in the renal cortex and medullary tissues. Renal cortical and medullary mRNA expression of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) as well as the collagen contents were increased in aldosterone/salt-treated hypertensive rats. Treatment with olmesartan (10 or 100 mg/kg/day) had no effect on blood pressure but attenuated proteinuria in a dose-dependent manner. Olmesartan at 10 mg/kg/day tended to decrease renal cortical and medullary Ang II levels, TGF-beta and CTGF expression, and collagen contents; however, these changes were not significant. On the other hand, an ultrahigh dose of olmesartan (100 mg/kg/day) significantly decreased these values and ameliorated renal injury. These data suggest that augmented local Ang II activity contributes, at least partially, to the progression of aldosterone/salt-dependent renal injury. 相似文献
7.
Ryuichi Matsumoto I. Nakano Nobutaka Arai Minami Suda Masaya Oda 《Acta neuropathologica》1996,92(6):640-644
This report concerns a notable case of progressive supranuclear palsy exhibiting asymmetric dentate nucleus and thalamic
degeneration with numerous torpedoes. The neuronal loss in the ventral lateral nucleus of the thalamus was predominant on
the right side, while in the cerebellum, a quantitative study revealed the contralateral predominance of the neuronal loss
in the dentate nuclei and torpedo formation, with preserved Purkinje cells. The abnormal tau-protein-related profiles in the
two nuclei did not show any laterality in their distribution, indicating that the dentatothalamic tract may have been affected
in a non-specific way in this case. In addition, the fact that the prominent sites of torpedo formation and loss of dentate
nucleus neurons are identical supports the hypothesis that the torpedoes may be formed in association with neuronal loss in
the dentate nucleus because of a plausible metabolic change in Purkinje cells through synaptic detachment of their axon terminals.
Received: 4 January 1996 / Revised: 27 March 1996 / Accepted: 5 April 1996 相似文献
8.
Yasuhiko Tamada Kikuka Yokochi Yoshimi Oshitani Yukiko Nitta Toshihiko Ikeya Kazuo Hara Katsushi Owaribe 《The Journal of dermatology》1995,22(3):201-204
We report a 73-year-old woman with typical clinical, histological and immunofluorescence features of pemphigoid nodularis. Direct immunofluorescence studies of prurigo nodularis-like lesions and peribullous skin showed the linear deposition of IgG and C3 at the basement membrane zone. Circulating IgG against the basement membrane was also detected by indirect immunofluorescence. The serum from the patient was shown to contain the autoantibody against 230 kDa hemidesmosomal antigen associated with bullous pemphigoid antigen. 相似文献
9.
Kazuaki Fukahara Kazutomo Minami Bert Hansky Sebastian A Schulte-Eistrup Gero Tenderich Uwe Schulz Reiner Koerfer 《The Journal of heart and lung transplantation》2003,22(4):468-473
The association is well established between congenital heart disease and spinal deformities such as scoliosis or kyphosis, but data are not available for risks and the outcome of heart surgery in patients with spinal deformities. We report a case of successful orthotopic heart lung transplantation in a patient with complex congenital heart disease and severe chest deformity who had undergone previous spinal fusion surgery for progressive right convex thoracic kyphoscoliosis. 相似文献
10.
C4d Deposition and Clearance in Cardiac Transplants Correlates With Alloantibody Levels and Rejection in Rats 总被引:4,自引:3,他引:1
K. Minami K. Murata C.-Y. Lee K. Fox-Talbot B. A. Wasowska M. D. Pescovitz W. M. Baldwin III 《American journal of transplantation》2006,6(5P1):923-932
Antibody-mediated rejection of human cardiac transplants is correlated with C4d deposits and macrophage infiltrates in capillaries of endomyocardial biopsies. We produced an antibody to rat C4d to study C4d deposition and clearance in Lewis rats that were sensitized with a blood transfusion from DA rats 7, 14 or 21 days before cardiac transplantation. Cyclosporin A (CsA) immunosuppression was initiated after transplantation at a dose that inhibited graft rejection, antibody production and C4d deposition in unsensitized recipients. Blood transfusion elicited high levels of circulating IgG alloantibodies, predominantly of the complement-activating IgG2b subclass, that peaked 14 days after transplantation. At this time, macrophages accumulated in capillaries, and C4d deposits were diffuse and intense on arteries, capillaries and veins. Grafts that survived 90 days in sensitized recipients still had deposits of C4d that were associated with increased interstitial fibrosis and vasculopathy in arteries. Clearance of C4d was determined by retransplanting DA cardiac allografts from Lewis recipients back to DA recipients. C4d deposits were decreased to minimal levels within 5 days after retransplantation. Thus, C4d deposition is not limited to the capillaries, but extends throughout the arterial tree, and despite formation of a covalent bond, C4d is cleared within days. 相似文献