全文获取类型
收费全文 | 1931篇 |
免费 | 118篇 |
国内免费 | 98篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 60篇 |
妇产科学 | 26篇 |
基础医学 | 157篇 |
口腔科学 | 142篇 |
临床医学 | 283篇 |
内科学 | 408篇 |
皮肤病学 | 109篇 |
神经病学 | 122篇 |
特种医学 | 111篇 |
外科学 | 287篇 |
综合类 | 78篇 |
一般理论 | 1篇 |
预防医学 | 70篇 |
眼科学 | 57篇 |
药学 | 140篇 |
中国医学 | 10篇 |
肿瘤学 | 73篇 |
出版年
2023年 | 15篇 |
2022年 | 15篇 |
2021年 | 33篇 |
2020年 | 32篇 |
2019年 | 38篇 |
2018年 | 44篇 |
2017年 | 52篇 |
2016年 | 38篇 |
2015年 | 37篇 |
2014年 | 71篇 |
2013年 | 83篇 |
2012年 | 96篇 |
2011年 | 86篇 |
2010年 | 92篇 |
2009年 | 62篇 |
2008年 | 63篇 |
2007年 | 109篇 |
2006年 | 71篇 |
2005年 | 75篇 |
2004年 | 48篇 |
2003年 | 65篇 |
2002年 | 43篇 |
2001年 | 46篇 |
2000年 | 33篇 |
1999年 | 29篇 |
1998年 | 40篇 |
1997年 | 57篇 |
1996年 | 38篇 |
1995年 | 46篇 |
1994年 | 40篇 |
1993年 | 30篇 |
1992年 | 22篇 |
1991年 | 15篇 |
1990年 | 35篇 |
1989年 | 38篇 |
1988年 | 23篇 |
1987年 | 22篇 |
1986年 | 22篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 12篇 |
1977年 | 12篇 |
1976年 | 15篇 |
1965年 | 12篇 |
1963年 | 11篇 |
1959年 | 13篇 |
排序方式: 共有2147条查询结果,搜索用时 15 毫秒
1.
2.
Kai-Hang Yiu MBBS Chung-Wah Siu MBBS Chu-Pak Lau MD Kathy L.F. Lee MBBS Hung-Fat Tse MD 《Heart rhythm》2007,4(2):221-223
We report a case of successful transvenous, catheter-based, cavotricuspid isthmus ablation for treatment of atrial flutter using microwave energy. Microwave energy was delivered at 900–930 MHz using 21 W of power. Bidirectional cavotricuspid isthmus conduction block was achieved by microwave ablation without any patient discomfort or complication during the procedure. Our initial experience suggests that transcatheter microwave ablation is feasible for the cure of typical atrial flutter. 相似文献
3.
4.
5.
Rice varieties with similar amylose content differ in starch digestibility and glycemic response in humans 总被引:7,自引:0,他引:7
L N Panlasigui L U Thompson B O Juliano C M Perez S H Yiu G R Greenberg 《The American journal of clinical nutrition》1991,54(5):871-877
Three high-amylose rice varieties, IR42, IR36, and IR62, with similar chemical composition including amylose content (26.7-27.0%), were cooked under the same conditions and tested for in vitro digestibility as well as blood glucose and insulin responses in healthy human volunteers. The starch-digestion rate and the glycemic and insulin responses were the highest in IR42, followed by IR36 and, then IR62. The differences were not due to unabsorbed carbohydrate but were related to their physicochemical properties, such as gelatinization temperature, minimum cooking time, amylograph consistency, and volume expansion upon cooking. When the three varieties were cooked for their minimum cooking time, they had the same degree of gelatinization and their starch-digestion rates and glycemic responses were similar. We conclude that amylose content alone is not a good predictor of starch-digestion rate or glycemic response. Rice varieties with similar high-amylose contents can differ in physicochemical (gelatinization) properties and this, in turn, can influence starch digestibility and blood glucose response. 相似文献
6.
Gopala K RANGAN Yiping WANG Yuet-Ching TAY Liguang CHEN David CH HARRIS 《Nephrology (Carlton, Vic.)》1998,4(1-2):57-64
SUMMARY: The effect of mild acute tubular injury on the progression of tubulointerstitial fibrosis was studied in pair-fed uninephrectomized male Wistar rats with established adriamycin nephrosis ( n = 34). Rats were stratified into three groups according to endogenous creatinine clearance (CrCl), proteinuria (Upr) and body weight (BW): (i) group 1 (Fe, n = 12) received a single intraperitoneal injection of ferric nitrilotriacetate (5 mg Fe/kg BW); (ii) group 2 (G, n = 10) three daily subcutaneous injections of gentamicin (60 mg/kg BW) and; (iii) group 3 (C, n = 12) saline injections. Serial CrCl (day 2, day 5, weeks 2, 4, 6 and 8) and renal histology (week 8) were examined following administration of nephrotoxin. CrCl was reduced on d2 (Fe: 0.78 ± 0.23 mL/min; mean ± SD) and day 5 (G: 0.91 ± 0.36 mL/min) as compared with C (1.22 ± 0.12 mL/min; P <0.05). There was no change in the serum creatinine and functional recovery occurred by d5 (Fe) and week 2 (G). Upr decreased transiently in G at week 2 (G: 482 ± 208 mg/day vs C: 716 ± 233; P = 0.05) despite similar food intake, baseline Upr and CrCl. At week 8, CrCl in Fe (0.84 ± 0.40 mL/min) was similar to C (0.84 ± 0.58 mL/min), whereas in G it remained stable (1.27 ± 0.39 mL/min; P <0.05). By morphometric analysis, mean relative interstitial volume (RIV) and glomerulosclerosis (GS) in Fe (RIV: 28.5 ± 13.4%; GS: 10.3 ± 12.3%) was no different to C (RIV: 24.5 ± 12.5%; GS: 20.9 ± 20.0%), whereas both parameters were reduced in G (RIV: 14.1 ± 8.1%; GS: 4.0 ± 4.8%; P <0.05). Mild gentamicin nephrotoxicity therefore reduced the progression of adriamycin nephrosis. the mechanism of this finding is unclear, but it may relate to altered glomerular and tubular cell handling of protein. 相似文献
7.
Paired kidney analysis of tacrolimus and cyclosporine microemulsion-based therapy in Chinese cadaveric renal transplant recipients 总被引:5,自引:0,他引:5
Chi Yuen Cheung Kim Ming Wong Hoi Wong Chan Yan Lun Liu Yiu Han Chan Ho Sing Wong Wai Leung Chak Koon Shing Choi Ka Foon Chau Chun Sang Li 《Transplant international》2006,19(8):657-666
Few studies used paired kidneys for comparison between tacrolimus and cyclosporine in renal transplantation. Most of the published data used whole blood trough levels for drug monitoring. However, the use of limited sampling strategy and abbreviated formula to estimate the 12-h area under concentration-time curve (AUC(0-12)) allowed better prediction of drug exposure. Sixty-six first cadaveric renal transplant recipients receiving paired kidneys were randomized to receive either tacrolimus-based (n = 33) or cyclosporine microemulsion (Neoral)-based therapies (n = 33). Abbreviated AUC(0-12) was used for drug monitoring and dose titration. Mean follow-up duration was 2.8 +/- 2 years. The patient and graft survival were comparable. Fewer incidence of acute rejection was observed in tacrolimus group (15% vs. 27.3%) though the difference was not significant (P = 0.23). The absolute value and the rate of decline of creatinine clearance were both significantly better in tacrolimus-treated patients. Prevalence of hypertension, post-transplant diabetes mellitus, infection, and malignancy were similar in both groups. Prevalence of hypercholesterolemia (11/33 vs. 4/33) and gum hypertrophy (6/33 vs. 1/33) was more common in cyclosporine-treated patients (P = 0.04 in both parameters). This was the first prospective, randomized study with paired kidney analysis showing the renal function was significantly better in tacrolimus-treated patients than in cyclosporine-treated patients. 相似文献
8.
9.
无环鸟苷亲脂性前体药物脂质体的制备及体外抗病毒活性(英文) 总被引:2,自引:0,他引:2
本文通过将无环鸟苷(acyclovir,简称ACV)2’位羟基分别与月桂酰氯或棕榈酰氯进行酯化反应,制得亲脂性前体药物无环鸟苷月桂酸酯和无环鸟苷棕榈酸酯(分别简称为C12-ACV和C16-ACV),使脂质体包封率从ACV的29.9%提高到C12-ACV的95.6%和C16-ACV的97.1%;漏泄实验表明在4℃透析60h后,一半以上的ACV从脂质体中漏泄,而C12-ACV和C16-ACV的滞留率分别为70%和80%;体外抗疱疹病毒的试验中,在最低试验浓度0.044μmol/L时,ACV不显示抗病毒活性,而C16-ACV脂质体抑制细胞病变率达75%,说明前体药物通过与脂质体脂膜的结合增加了药物的进入细胞能力,从而提高了ACV的抗病毒能力。 相似文献
10.
Verna W. Y. Yiu Robert P. Dluhy Richard P. Lifton Lisa M. Guay-Woodford 《Pediatric nephrology (Berlin, Germany)》1997,11(3):343-346
In evaluating hypertensive children and adolescents, the etiological considerations should include a set of inherited disorders
that share very low plasma renin activity (PRA) as a common feature. In particular among these disorders, glucocorticoid remediable
aldosteronism (GRA) appears to be emerging as an important etiology of hypertension in the pediatric population. We report
the evaluation of a 9-year-old Caucasian girl who presented with severe hypertension and a strong family history of early-onset
hypertension. Her suppressed PRA, her family history, and her failure to respond to conventional antihypertensive therapy
raised GRA as a potential etiology. The diagnosis was confirmed by an elevated ratio of urinary 18-oxotetrahydrocortisol to
urinary tetrahydroaldosterone and genetic testing, which demonstrated the chimeric gene duplication. The molecular pathogenesis
of GRA and the clinical implications are reviewed.
Received May 15, 1996; received in revised form and accepted September 16, 1996 相似文献