后尿道损伤的早期,亚早期手术治疗

１９７３－１９９４年５月共收治骨盆骨折所致的后尿道断裂５４例，其中行早期尿道吻合３３例，亚早期尿道吻合９例，占７７．８％（４２．５４），均取得满意效果，尿道断早期组织弹性好，无粘连，无瘢痕，可以达到解剖对位。手术同时可以清除血肿及外渗尿液，减少感染及狭窄机会，对合并休克的病人在休克纠正后，处理其他复合伤的同时急尽早行尿道对端吻合术。对伤严重的的病人经抢救休克处理复合伤，生命指标平稳后行亚早期手术仍     

儿童体外循环心脏手术对甲状腺功能的影响

目的 观察儿童体外循环心脏手术前后甲状腺激素的变化,了解体外循环心脏手术对儿童甲状腺功能的影响并探讨其临床意义。方法 用放射免疫方法测定２５例外循环心脏手术儿童术前、术中、术后甲状腺激素和促甲状腺激素的含量。结果 体外循环期间血浆三碘甲状腺原氨酸（ｔｅｔｒｏｄｏｔｈｙｒｏｎｉｎｅ,Ｔ３）、游离三碘甲状腺原氨酸（ｆｒｉｉ ｔｒｉｉｏｄｏｔｈｙｒｏｎｉｎｅ,ＦＴ３）、四碘甲状腺原氨酸（ｔｅｔｒａｉｏｄ     

Toll样受体基因多态性与福建籍非人类免疫缺陷病毒相关隐球菌性脑膜炎易感性的关联分析

目的:探讨Toll样受体(Toll-like receptor,TLR)基因多态性与福建籍非人类免疫缺陷病毒(human immunodeficiency virus,HIV)相关隐球菌性脑膜炎易感性的关联。方法:纳入2016年10月至2019年4月在上海市复旦大学附属华山医院和福建省福州市联勤保障部队第九〇〇医院仓山院区住院治疗的101例福建籍非HIV相关隐球菌性脑膜炎患者为病例组,270名福建籍门诊健康体格检查者为健康对照组。提取患者基因组DNA,采用多重SNaPshot单核苷酸多态性(single nucleotide polymorphism,SNP)分型技术,对既往文献报道的与疾病相关但未得到充分验证的8个TLR SNP位点进行基因分型。分别比较病例组和健康对照组、无易感因素患者组和健康对照组TLR基因多态性的分布差异。统计学分析采用χ²检验或Fisher确切概率法。结果:除TLR1 rs5743563外,TLR1 rs5743604、TLR2 rs3804099、TLR4 rs1927907、TLR6 rs3796508、TLR6 rs5743794、TLR9 rs164637、TLR9 rs3521407个TLR SNP检测位点的等位基因频率分布均符合哈迪-温伯格平衡。病例组与健康对照组比较发现,TLR2 rs3804099位点的T/T基因型[52.5%(53/101)比40.4%(109/270),比值比(odds ratio,OR)=1.63,χ²=4.378,P=0.036]和TLR6 rs5743794位点的G/G基因型[44.6%(45/101)比32.2%(87/270),OR=1.69,χ²=4.877,P=0.027]为隐球菌性脑膜炎的风险基因型;而TLR6 rs3796508的G/G基因型[83.2%(84/101)比92.6%(250/270),OR=0.40,χ²=7.271,P=0.007]和TLR9 rs164637的C/C基因型[96.0%(97/101)比100.0%(270/270),Fisher确切概率法,P=0.005]为隐球菌性脑膜炎的保护性因素。101例患者中有70例无易感因素。无易感因素患者组与健康对照组比较发现,TLR6 rs5743794位点的G/G基因型[52.9%(37/70)比32.2%(87/270),OR=2.36,χ²=10.216,P=0.001]为隐球菌性脑膜炎的风险基因型,TLR6 rs3796508的G/G基因型[81.4%(57/70)比92.6%(250/270),OR=0.35,χ²=7.906,P=0.005]和TLR9 rs164637的C/C基因型[97.1%(68/70)比100.0%(270/270),Fisher确切概率法,P=0.042]为隐球菌性脑膜炎的保护性因素。结论:TLR基因多态性与福建籍非HIV相关隐球菌性脑膜炎的易感性密切关联,提示TLR在隐球菌性脑膜炎的发病过程中可能起到重要作用。     

前牙开He正畸治疗和外科治疗的限度

目的探讨前牙开畸形正畸治疗与外科治疗的界限.方法选择正畸治疗开患者7 0人,平均年龄18.0岁;外科治疗开患者14人,平均年龄25.1岁.对经计算机头影测量得出的154项颅面软硬组织测量项目值进行单因素和多因素判别分析.结果下切牙下颌平面角(L1MP)可作为单因素判别指标,当其值≤89.5°时,可判断为外科治疗的适应证,》89.5°时则判断为正畸治疗.根据多因素逐步判别分析建立的判别函数 Z=-0.80188 L1MP+0.91401 Age+0.671111 Antigonial notch-MP+0.599992 SNPg, 当Z≥0时,判定为外科治疗组,Z《0 时判为正畸治疗组. 结论单因素判别指标和多因素判别函数均可用于确定正畸治疗与外科治疗的界限,判别函数优于单因素判别指标.     

Molecular determination of agouti-related protein binding to human melanocortin-4 receptor

Agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin-4 receptor (MC4R) that functions in the hypothalamic control of feeding behavior. Our previous studies have suggested that in addition to exoloops 2 and 3, several transmembrane domains of MC4R may be important for AGRP binding. However, the detailed molecular basis of MC4R domains in AGRP binding is presently unclear. The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP. Our results indicate that substitutions of the second and third extracellular loops of the MC4R with homologous domains of the MC1R dramatically decreased AGRP 87-132 binding affinity, but did not affect AGRP 110-117 binding affinity. In contrast, cassette substitutions of the third or fourth transmembrane domain of the MC4R with the homologous domain of the MC1R resulted in a substantial decrease of AGRP 87-132 binding affinity and loss of AGRP 110-117 binding affinity. These data suggest that the AGRP fragment 110-117 has no binding sites at exoloops of hMC4R and that transmembrane domains of MC4R may play an important role in AGRP 110-117 binding and function, whereas the exoloops do not. The second and third extracellular loops of MC4R are important for AGRP 87-132 N-terminal binding, whereas the third and fourth transmembrane domains of hMC4R are crucial for AGRP 110-117 binding.     

口服碘油丸对甲状腺自身抗体的影响

观察了山东省重度缺碘病区人群服用４００ｍｇ碘油前后的甲状腺自身抗体水平。服药前甲状腺自身抗体ＴｍＡｂ和ＴｇＡｂ均阴性，而服药一年、一年半和二年后分别出现５、６、１０例抗体阳性患者；服药后的ＴｍＡｂ、ＴｇＡｂ水平均明显高于服药前。提示服用碘油丸很可能会影响甲状腺自身抗体而诱发甲状腺自身免疫性疾病，应引起重视。     

Sonochemistry-enabled uniform coupling of SnO2 nanocrystals with graphene sheets as anode materials for lithium-ion batteries

SnO₂/graphene nanocomposite was successfully synthesized by a facile sonochemical method from SnCl₂ and graphene oxide (GO) precursors. In the sonochemical process, the Sn²⁺ is firstly dispersed homogeneously on the GO surface, then in situ oxidized to SnO₂ nanoparticles on both sides of the graphene nanosheets (RGO) obtained by the reduction of GO under continuous ultrasonication. Graphene not only provides a mechanical support to alleviate the volume changes of the SnO₂ anode and prevent nanoparticle agglomeration, but also serves as a conductive network to facilitate charge transfer and Li⁺ diffusion. When used as a lithium ion battery (LIB) anode, the SnO₂/graphene nanocomposite exhibits significantly improved specific capacity (1610 mA h g⁻¹ at 100 mA g⁻¹), good cycling stability (retaining 87% after 100 cycles), and competitive rate performance (273 mA h g⁻¹ at 500 mA g⁻¹) compared to those of bare SnO₂. This sonochemical method can be also applied to the synthesis of other metal-oxide/graphene composites and this work provides a large-scale preparation route for the practical application of SnO₂ in lithium ion batteries.

SnO₂/graphene nanocomposite was successfully synthesized by a facile sonochemical method from SnCl₂ and graphene oxide (GO) precursors.     

老年脑梗塞急性期血浆t—PA PAI—1VWF活性早晚变化研究

本文目的是研究人血浆中三种物质的活性水平及早晚变化规律在两组间的差异,并探讨其与脑梗塞发病间的关系。     

恒牙期前牙开正畸治疗时机和疗效的研究

目的　通过对恒牙初期和恒牙晚期正畸治疗成功的病例进行分析 ,探讨恒牙期前牙开患者正畸治疗的时机及引起颅面形态的变化。方法　选择 13名恒牙初期和 12名恒牙期前牙开患者 ,利用计算机X线头影测量分析治疗前后的软硬组织变化 ,并进行统计学处理。结果　正畸的治疗变化以牙齿倾斜度的变化为主 ,前牙有一定的伸长 ,垂直高度有所增加 ,软组织面型有一定程度的改善。恒牙初期与恒牙期正畸治疗相比 ,除了上下前牙倾斜度的变化以外 ,还存在一定的下颌逆时针旋转趋势 ,而恒牙期者下颌平面角有顺时针旋转倾向。结论　提倡在恒牙初期即开始正畸治疗。