奇正青鹏膏剂配合超短波治疗肩关节周围炎的观察

目的:观察毫米波配合青鹏膏剂对肩关节周围炎治疗的有效性及其应用中出现的不良反应。方法:选择2007年10月～2009年01月在我院门诊就诊的肩关节周围炎患者81例,采用区组随机化方法将81例患者分为治疗组(n=41)和对照组(n=40)。治疗组在患处外涂青鹏膏剂的基础上再给予超短波治疗,对照组给予单纯超短波治疗。利用视觉模拟评分法和肩关节活动功能评分进行疗效分析,同时观察治疗过程中有无不良反应发生。结果:①对照组和治疗组治疗1周后疼痛均有改善,但两组差异无统计学意义(P>0.05);治疗后2周治疗组优于对照组(P<0.05)。②治疗后两组肩关节活动功能的均改善,治疗组和对照组结果差异有统计学意义(P<0.05),治疗组优于对照组。③治疗组患者外用青鹏膏剂,未发生局部皮肤瘙痒、破溃等不良反应。结论:超短波配合青鹏膏剂具有能迅速减轻肩周炎患者疼痛的作用,在改善肩关节活动功能方面也有突出的效果。     

Effects of mycophenolic acid–glucosamine conjugates on the base of kidney targeted drug delivery

Mycophenolic acid has played an important role in treating immunosuppression and autoimmune diseases. Nevertheless, the agent needs a high dosage in treatment, following some side effects. To tackle this problem, in this study, mycophenolic acid–glucosamine conjugate (MGC), modified by 2-glucosamine, was synthesized to achieve kidney targeting and improved drug efficacy with a lower dosage. ¹H NMR, ¹³C NMR and HRMS spectroscopy were used to verify the conjugate whose stability was good in vitro. The transport of MGC by human proximal renal tubular epithelial HK-2 cells was temperature-, time-, concentration-dependent and saturable, suggesting the involvement of carrier-mediated uptake. In addition, the cellular uptake of MGC dropped substantially with the inhibition of megalin receptor. The specific tissue distribution indicated the commendable renal-targeting capability of MGC. The concentration of MGC was improved in the kidney except for other tissues, about 6.76 times higher than that of MPA. Further, the bioavailability of MGC in plasma decreased as compared with mycophenolic acid. Moreover, therapeutic effect of MGC was enhanced significantly compared with MPA in the acute kidney injury model. All the findings suggested the potential of mycophenolic acid–glucosamine conjugate in kidney targeted drug delivery.