排序方式： 共有63条查询结果，搜索用时 15 毫秒
1.
Erdal Simay Nalbantoğlu Banu Gür Mert Berke Yıldırım Murathan Kılıçarslan Alperen Kaymaz-Tahra Sema Alibaz-Öner Fatma Yay Meral Mumcu Gonca Direskeneli Haner 《Clinical rheumatology》2021,40(10):4109-4116
Clinical Rheumatology - The aim of this study was to evaluate the relationships among the disease activity, illness perception, daily life performance, anxiety and depression status as potential... 相似文献
2.
目的 总结慢性心力衰竭患者容量管理的最佳证据,为临床护理干预提供循证依据。
方法 按照“6S”证据资源金字塔模型,系统检索国内外循证数据库、指南网、协会网站、相关原始文献数据库中有关慢性心力衰竭患者容量管理的指南、最佳临床实践信息手册、证据总结、专家共识、系统评价,检索时限为建库至2022年3月。由2名接受过循证培训的研究人员独立完成质量评价,结合专业知识,对符合质量评价标准的文献进行证据提取及总结。
结果 共纳入20篇文献,包括指南8篇、证据总结2篇、专家共识6篇、系统评价1篇、随机对照试验3篇。总结包含容量状态评估、容量管理目标、容量管理措施、多学科团队合作、过渡期护理、健康教育及随访7个方面的24条证据。
结论 现有慢性心力衰竭患者容量管理的证据较为全面,可指导临床护理工作的开展。 相似文献
3.
4.
5.
目的 调查三甲医院护士参与“互联网+护理服务”的意愿，分析其影响因素，为“互联网+护理服务”在湖州的顺利开展提供参考。方法 对湖州市三甲医院500名符合国家“互联网+护理服务”资质的护士，采用自制的“互联网+护理服务”意愿调查问卷进行调查。结果 30.80%的护士知晓“互联网+护理服务”政策；37.00%愿意参与“互联网+护理服务”，18.40%拒绝，44.60%持观望态度；PICC/输液港护理（64.95%）、静脉注射（63.97%）、留置引流管的护理（63.48%）、静脉输液（63.24%）、皮下及肌内注射（62.25%）及鼻饲（61.27%）是参与意愿较高的护理服务项目；护士政策知晓度、是否有足够空余时间、“互联网+护理”从业经历是影响护士参与“互联网+护理服务”意愿的主要因素。结论 护士对“互联网+护理服务”的总体参与意愿较低，而业余时间充裕、有“互联网+护理服务”从业经历以及对该项政策存在一定知晓度的护士对“互联网+护理服务”的参与意愿更强。应从多方位加大“互联网+护理服务”的推广教育，促进“互联网+护理服务”有序开展。 相似文献
6.
Osman Çevik Özlem Öz Gergin Karamehmet Yildiz Adnan Bayram Özlem Canöz Mehmet Halici Münevver Baran Arzu Yay Sait Polat 《Brazilian Journal of Anesthesiology》2018,68(6):605-612
Background
A single dose injection or continuous infusion of local anesthetics into the joint space is considered to be a well‐defined analgesia technique. The aim of this study was to investigate the chondrotoxic and apoptotic effects of single‐dose intra‐articular injection of levobupivacaine and bupivacaine on rabbit knee joint tissues.Materials and methods
The animals were allocated into two groups each containing 20 rabbits. 0.5% levobupivacaine (Group L) and 0.5% bupivacaine (Group B) were applied intra‐articularly to the left posterior joints of rabbits. At the same time, normal saline was applied to the right posterior leg knee joints of rabbits in both groups and used as a control (Group S). At the end of the 7 th and 28th days after the intraarticular injections, ten randomly chosen rabbits in each group were killed by applying intraperitoneal thiopental. Sections of cartilage tissue samples were stained for light microscopic examinations and the TUNEL method was used to investigate apoptotic cells.Results
As a result of immunofluorescence microscopic examination, the number of apoptotic cells in Group B at day 7 and day 28 were both significantly higher than Group L and S (p < 0.05). Also, the number of apoptotic cells in Group L at day 7 and day 28 were both significantly higher than Group S (p < 0.05).Conclusions
We found that bupivacaine is more chondrotoxic than other anesthetic agent and increases the number of apoptotic cells. These results indicated that bupivacaine caused high chondrotoxic damage and it led to more apoptotic activation than levobupivacaine. 相似文献7.
Özlem Öz Gergin Karamehmet Yıldız Adnan Bayram Leman Sencar Gülfidan Coşkun Arzu Yay 《Ultrastructural pathology》2015,39(3):169-176
The aim of this study was to investigate the myotoxic effects of bupivacaine, ropivacaine, and levobupivacaine which were applied intramuscularly to rat skeletal muscle. Forty Wistar-Albino rats were divided into four groups. In the study, .5% bupivacaine (Group B), .5% ropivacaine (Group R), .5% levobupivacaine (Group L), or .9% normal saline (Group SF) was applied intramuscularly to the right gastrocnemius muscle of rats. The rats in each group were sacrificed on the second day after injection. Sections of muscle samples were stained with hematoxylin–eosin for light microscopic investigation and prepared for the evaluation of ultrastructural changes in the subcellular level with transmission electron microscopy. All three local anesthetic agents caused qualitatively similar skeletal muscle damage. The most observed muscle damage was in Group B, muscle damage of Group R was less than that of Group B, and the least damage was seen in Group L quantitatively. Electron microscopic examination of each group that caused cellular damage was qualitatively similar. The most subcellular damage was observed in the group receiving bupivacaine, less was seen in the ropivacaine group, and the least was observed in the levobupivacaine group. The results indicated that bupivacaine caused more myotoxic damage than the other two agents in the skeletal muscle of rats and that levobupivacaine caused less myotoxic damage than both bupivacaine and ropivacaine at the cell and tissue levels. 相似文献
8.
Effects of colchicine on gingival inflammation,apoptosis, and alveolar bone loss in experimental periodontitis 
下载免费PDF全文
下载免费PDF全文 Cüneyt Asım Aral Kübra Aral Arzu Yay Özge Özçoban Afig Berdeli Recep Saraymen 《Journal of periodontology》2018,89(5):577-585
1 Background
The aim of the study was to investigate the effects of colchicine on cytokine production, apoptosis, alveolar bone loss, and oxidative stress in an experimental model of periodontitis in rats.2 Methods
Forty‐eight rats were divided equally into four groups: healthy (H); periodontitis (P); periodontitis+colchicine low dose (CL, 30 μg/kg/day), and periodontitis+colchicine high dose (CH, 100 μg/kg/day). After 11 days, interleukin (IL) ‐1β, IL‐8, and IL‐10 were analyzed in gingival samples using Enzyme‐Linked ImmunoSorbent Assay. Receptor activator of nuclear factor kappa‐B ligand (RANKL), osteoprotegerin (OPG), total oxidative stress (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were measured in gingiva and serum. Alveolar bone volume was evaluated via micro‐CT. Apoptotic cells were detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay in histological sections.3 Results
Colchicine treatment significantly reduced IL‐1β, IL‐8, RANKL, RANKL/OPG, TOS, OSI, and bone volume ratio levels, and increased TAS levels compared to group P (p < 0.05). High dose colchicine treatment (CH) significantly decreased TUNEL+ cell counts compared to group P (p < 0.05).4 Conclusions
These finding suggest that colchicine has a prophylactic potential for the prevention of periodontal tissue destruction through anti‐inflammatory, anti‐oxidative, anti‐apoptotic, and bone‐protective effects. 相似文献9.
10.
目的:了解四川地区抗肿瘤药物风险分级现状及需求,以构建抗肿瘤药物风险提示系统,提高抗肿瘤药物临床应用的安全性和有效性。方法:采用调查问卷了解四川地区抗肿瘤药物风险分级现状及需求。结果:受访医务人员所在医院的抗肿瘤药物使用现状：63.29%存在抗肿瘤药物的超说明书用药,77.22%有抗肿瘤药物处方前置审核系统,82.28%为一线医师开具抗肿瘤药物处方需要上级医师审核,91.14%为配置静脉用抗肿瘤药物使用生物安全柜,86.08%为医务人员在配置抗肿瘤药物时穿戴防护用具,78.48%为抗肿瘤药物高危标识嵌入电子信息系统,81.01%有抗肿瘤药物的分级管理制度,81.01%有抗肿瘤药物分级管理目录;受访医务人员对抗肿瘤药物的风险因素及风险防范的认知程度一般,而医师、护士和药师对抗肿瘤药物风险点的风险程度认知有所不同;受访医务人员希望构建抗肿瘤药物风险提示系统并建议了相关影响因素的重要性。结论:四川地区抗肿瘤药物风险分级现状较好,受访医务人员对肿瘤药物的风险因素及风险防范的认知程度侧重于其工作岗位,强烈要求构建抗肿瘤药物风险提示系统。 相似文献