全文获取类型
收费全文 | 27686篇 |
免费 | 1143篇 |
国内免费 | 134篇 |
专业分类
耳鼻咽喉 | 300篇 |
儿科学 | 455篇 |
妇产科学 | 453篇 |
基础医学 | 3562篇 |
口腔科学 | 502篇 |
临床医学 | 1644篇 |
内科学 | 6534篇 |
皮肤病学 | 423篇 |
神经病学 | 2548篇 |
特种医学 | 1218篇 |
外科学 | 4274篇 |
综合类 | 102篇 |
一般理论 | 5篇 |
预防医学 | 835篇 |
眼科学 | 769篇 |
药学 | 1817篇 |
中国医学 | 31篇 |
肿瘤学 | 3491篇 |
出版年
2022年 | 203篇 |
2021年 | 426篇 |
2020年 | 219篇 |
2019年 | 314篇 |
2018年 | 430篇 |
2017年 | 357篇 |
2016年 | 430篇 |
2015年 | 446篇 |
2014年 | 589篇 |
2013年 | 786篇 |
2012年 | 1262篇 |
2011年 | 1321篇 |
2010年 | 738篇 |
2009年 | 657篇 |
2008年 | 1232篇 |
2007年 | 1405篇 |
2006年 | 1391篇 |
2005年 | 1372篇 |
2004年 | 1348篇 |
2003年 | 1289篇 |
2002年 | 1413篇 |
2001年 | 751篇 |
2000年 | 807篇 |
1999年 | 772篇 |
1998年 | 383篇 |
1997年 | 342篇 |
1996年 | 308篇 |
1995年 | 286篇 |
1994年 | 285篇 |
1993年 | 265篇 |
1992年 | 684篇 |
1991年 | 593篇 |
1990年 | 592篇 |
1989年 | 594篇 |
1988年 | 537篇 |
1987年 | 511篇 |
1986年 | 470篇 |
1985年 | 472篇 |
1984年 | 286篇 |
1983年 | 242篇 |
1982年 | 125篇 |
1981年 | 113篇 |
1980年 | 105篇 |
1979年 | 254篇 |
1978年 | 143篇 |
1977年 | 131篇 |
1975年 | 111篇 |
1974年 | 105篇 |
1973年 | 108篇 |
1969年 | 125篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Zhenzhen Zhang Mark Garzotto Tomasz M. Beer Philippe Thuillier Stephen Lieberman Motomi Mori 《Nutrition and cancer》2016,68(8):1309-1319
Animal and human studies suggest fish oil and green tea may have protective effect on prostate cancer. Fatty acid synthase (FAS) has been hypothesized to be linked to chemoprotective effects of both compounds. This study evaluated the independent and joint effects of fish oil (FO) and green tea supplement (epigallocatechin-3-gallate, EGCG) on FAS and Ki-67 levels in prostate tissue. Through a double-blinded, randomized controlled trial with 2 × 2 factorial design, 89 men scheduled for repeat prostate biopsy following an initial negative prostate biopsy were randomized into either FO alone (1.9 g DHA + EPA/day), EGCG alone (600 mg/day), a combination of FO and EGCG, or placebo. We used linear mixed-effects models to test the differences of prostate tissue FAS and Ki-67 by immunohistochemistry between pre- and post-intervention within each group, as well as between treatment groups. Results did not show significant difference among treatment groups in pre-to-post-intervention changes of FAS (P = 0.69) or Ki-67 (P = 0.26). Comparing placebo group with any of the treatment groups, we did not find significant difference in FAS or Ki-67 changes (all P > 0.05). Results indicate FO or EGCG supplementation for a short duration may not be sufficient to produce biologically meaningful changes in FAS or Ki-67 levels in prostate tissue. 相似文献
2.
3.
Masaru Sasaki Tsuyoshi Takahashi Soichiro Funaki Koji Tanaka Yasuhiro Miyazaki Naoko Ose Tomoki Makino Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Yasushi Shintani Masaki Mori Yuichiro Doki 《Asian journal of endoscopic surgery》2021,14(1):116-119
We report a case of a diaphragmatic hernia after a heart transplant operation. A 43-year-old woman, who underwent orthotropic heart transplantation for hypertrophic cadiomyopathy two year earlier, presented with vomiting and epigastric pain. A computed tomography scan showed that the stomach and transverse colon were dislocated in the left thoracic cavity. We diagnosed left diaphragmatic hernia incarceration and performed laparoscopic repair of the diaphragmatic hernia. A 12 × 8 cm diaphragmatic defect was found intraoperatively on the ventrolateral aspect of the left diaphragm, and the stomach with volvulus had herniated into the thorax through the defect. The hernia was considered to be iatrogenic. The diaphragmatic defect was large, and the diaphragm was thinning. We closed the defect by mesh repair. Laparoscopic mesh repair of the diaphragmatic hernia could be performed safely and with minimal invasiveness. 相似文献
4.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献5.
6.
7.
8.
Satoshi Iyama Yasuo Takahashi Naoaki Shintani Koshi Fujikawa Syunichi Ohkubo Yasushi Sato Tsutomu Sato Yasuhiro Sato Keisuke Ohnuma Yoshiro Niitsu 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1163-1168
We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic. 相似文献
9.
Takako Miyamae Masaaki Mori Yasuji Inamo Youichi Kohno Shuji Takei Motoharu Maeda Takuji Murata Shuji Nakata Hiroshi Kawai Yukiko Hirano Yukiji Date Katsuhiko Kitamura Shumpei Yokota 《Ryūmachi》2003,43(3):538-543
OBJECTIVES: To reveal the frequency and the clinical characteristics of dystrophic calcification that occurs in children with juvenile dermatomyositis, multi-center analysis was constructed. METHOD: Fifty children with JDM were enrolled, and 14 of them (28.0%) were complicated with calcinosis. Clinical symptoms and laboratory tests at onset, initial therapy and disease course were compared in children with and without calcinosis. RESULTS: The mean age of the onset of calcinosis was 4.78 +/- 3.33 years, and it was younger than those of children without calcinosis (8.66 +/- 3.85 years) (P = 0.0017). No differences of clinical manifestation except Gower's sign were observed. The frequency of positive anti-nuclear antibody was 7.1% in children with calcinosis and 52.9% without calcinosis (P = 0.0112). The initial therapy of methylprednisolon pulses gave no effects on prognosis of calcium deposition. The calcinosis appeared in 1.56 +/- 1.91 year after the onset of the disease. The various types of calcium deposition including large tumorous clumps, subcutaneous plaques or nodules, sheet-type calcification were deserved. They appeared over knee joints (64.3%), elbow joint (64.3%), and hip processes (50.0%). Calcinosis affecting the subcutaneous tissues frequently resulted in painful superficial ulceration of the overlying skin (42.9%), local infection (50.0%), and limitation of joint movement (14.3%). Although aluminum phosphate was effective in 2 children among 7, no other effective treatment was recommended. In 5 cases, surgical removal of tumorous clumps was operated. Thus, juvenile dermatomyositis is frequently complicated with calcinosis. This type of calcinosis was found to be unlikely to resolve completely, and resulted in severe disability in children. 相似文献
10.
Hidetaro Mori Keisuke Hiraoka Ryoichi Yorifuji Tohru Iwasaki Syuzo Gomikawa Ohshi Inagaki Seishi Inoue Yoshihiro Takamitsu Yoshikazu Fujita 《Artificial organs》1994,18(10):725-728
Abstract: The adsorptive characteristics of 5 dialysis membranes for recombinant human erythropoietin (EPO) were studied in vitro in a closed circuit system. For 120 min, EPO added with bovine serum was significantly adsorbed by polymethylmetacrylate (PMMA) and polyacry–lonitrile (PAN) membranes but not by Cuprophan, ethylene vinyl alcohol (EVAL), or polysulfone (PS) membranes. In addition the EPO adsorptive rate, as well as that of β2 –microglobulin (β2 –MG), was greater with a PMMA membrane than with a PAN membrane. EPO was not detected in the ultrafiltrate at 15 min with 5 membranes. These results indicate that EPO was eliminated by membrane adsorption only with some dialysis membranes. 相似文献