Non-invasive Assessment of Coronary Flow Velocity Reserve: A New Method Using Transthoracic Doppler Echocardiography

Coronary flow reserve (CFR) has been used toassess coronary microcirculation and epicardial coro-nary stenoses[1— 3 ] . CFR is defined as the ratio ofcoronary flow under maximal coronary vasodilatationto coronary flow under resting conditions[4 ] .Whenthe cross- sectional area of epicardial coronary arteriesis constant,coronary flow velocity (CFV) ratios areequal to volume flow ratios.The most common method used clinically formeasuring CFVR is intracoronary Doppler flow(ICD) analysis re…     

尿中δ-氨基乙酰丙酸的测定——对铅中毒诊断意义的探讨

本调查是对××冶炼厂227名接铅工人作了尿铅、尿中δ-ALA、尿粪卟啉及末梢血中碱粒红细胞的测定,同时与对照组进行了比较。结果表明:(1)接铅工人尿中δ-ALA检出均高出非接铅健康工人,且差别非常显著。(2)随着接铅工龄的增加,工人尿中δ-ALA的超标率也相应的增多。(3)接铅工人尿中δ-ALA的变化比CP要早,对铅的接触更敏感。(4)尿中δ-ALA与尿铅呈明显相关,而与碱粒红细胞相关不明显。     

佩尔地平治疗妊娠高血压病人的护理管理路径

目的探讨护理管理路径在应用佩尔地平治疗的重度子痫前期病人的效果，以期达到最佳的治疗效果，并减少并发症的发生。方法将用佩尔地平针治疗的重度子痫前期的病人486例随机分为两组，一组按常规护理，另一组按制定的护理管理路径护理。结果患者依从性对照组为168例，占70％；观察组为228例，占92．68％，P〈0．05，其差异有统计学意义。胎死宫内发生率对照组为9．16％，观察组为0．81％，P〈0．05，其差异有统计学意义。血压的稳定性对照组为36．3％，观察组为97．6％，P〈0．05，其差异有统计学意义。结论护理管理路径可以提高重度妊娠高血压疾病的治疗效果，减少并发症的发生。     

正常成人睾丸血流的彩色多普勒观察

为了探讨彩色多普勒血流显像技术显示正常人睾丸内血流的可行性，并探讨睾丸的血流动力学特征，我们对２０名正常人双侧睾丸进行了彩色多普勒检查。结果显示，彩色多普勒能显示所有睾丸的包膜动脉、向心动脉。正常睾丸的包膜动脉和向心动脉收缩期峰值血流速度的均值分别为９．００ｃｍ／ｓ和７．４２ｃｍ／ｓ；舒张末期血流速度均值分别为３．５０ｃｍ／ｓ和３．３８ｃｍ／３，本文对睾丸彩色血流显像和多普勒频谱特点也作了讨论。     

卡维地洛与美多心安对高血压患者治疗效果的比较研究

目的　评价国产卡维地洛的降压效应与安全性。方法　 90例原发性高血压患者随机分为观察组与对照组 ,分别口服国产卡维地洛 1片 (10mg)或美多心安 1片 (2 5mg) ,2次 /d ,4周为 1疗程。 结果　卡维地洛组服药 4周后收缩压 (SBP)及舒张压 (DBP)与治疗前比较分别下降 (18.92± 11.5 8)、(12 .34± 7.2 5 )mmHg(P <0 .0 1) ,美多心安组与治疗前比较分别下降 (19.13± 9.70 )、(13.5 0± 7.4 6 )mmHg(P <0 .0 1) ;观察组与对照组总有效率分别为 89.4 8%与 80 .4 3% ,两组比较无显著差异 (P >0 .0 5 )。两药的不良反应均轻微 ,发生率分别为 2 .7%和 4 .4 %。结论　卡维地洛是一种安全有效的抗高血压药物     

学术期刊关联数据出版与共享中的信息安全管理

【目的】 对我国学术期刊关联数据出版与共享中的信息安全管理的概念、政策及其存在的问题进行梳理,有助于科学数据出版与共享工作的推进。【方法】 基于我国科学数据出版与共享的演化过程,以及地理资源期刊在科学数据共享方面的现状与发展情况,对期刊论文关联数据出版和安全管理情况进行分析,对平台间合作的模式进行探讨。【结果】 为实现科学数据的价值最大化,中国自上而下建立起了科学数据共享系统,包括网络基础设施、数据库、数据中心、数据服务平台等,制定了一系列数据获取和管理规范,并制定了保障科学数据信息安全的相关法律。【结论】 科学数据出版与共享应建立在安全的基础上。经过初期的大规模建设后,数据出版与共享及其安全管理应走向“提质增效”阶段,要注重高新技术的注入和专业人才的培养。在管理措施上要以保证数据安全为基础,以数据质量为核心,从而提升信息安全管理水平,提高数据再应用效率。     

南沙参多糖对亚慢性受照小鼠的抗突变作用研究

目的：研究南沙参多糖对亚慢性受照小鼠抗突变作用。方法：用^60Cγ射线全身低剂量均匀间断照射小鼠106d，累计吸收剂量为3．25Gy，检测外周血白细胞数、血小板数、睾丸精原细胞染色体畸变率、精子畸形率和骨髓嗜多染红细胞微核率。结果：辐射损伤后，外周血白细胞数、血小板数降低；染色体畸变率、精子畸形率和骨髓嗜多染红细胞微核率均增加，南沙参多糖可促进上述指标的恢复。结论：南沙参多糖对亚慢性受照小鼠损伤具有明显的保护作用，其机制与抗氧化作用有关。     

苦豆子总碱对雄性小鼠生殖细胞辐射损伤的影响

目的:研究苦豆子总碱对60Coγ射线照射雄性小鼠生殖细胞的影响.方法:小鼠腹腔注射苦豆子总碱,采用60Coγ射线全身均匀照射,剂量为5.0Gy,检测受照小鼠染色体畸变率、精子畸形率、睾丸指数以及对其睾丸组织进行病理学观察.结果:辐射损伤后小鼠染色体畸变率、精子畸形率增加,睾丸指数下降并发生形态学改变.苦豆子总碱可促进上述受损指标的恢复.结论:苦豆子总碱对受照小鼠雄性生殖细胞具有一定的保护作用.     

Pharmacological effects of Chinese herb aconite (Fuzi) on cardiovascular system

Fuzi (aconite, Radix Aconiti praeparata), a widely used Chinese herb, plays a significant role in the cardiovascular system. This is mainly reflected by Fuzi's cardiotonic effect, its protective effect on myocardial cells, and its effect on heart rate and rhythm, blood pressure, and hemodynamics. In this article, the pharmacological effects and the corresponding mechanisms of Fuzi (aconite) and its active components on cardiovascular system are reviewed.     

Determination of plasma antiglycan autoantibodies in patients with IgA nephropathy and the correlation with clinical characteristics

Objective To establish the measurement of IgA1 O-glycan-specific antiglycan autoantibodies in patients with IgA nephropathy (IgAN), and evaluate their role in the development and progression of IgAN. Methods In the IgAN regular follow-up cohort of Peking University Institute of Nephrology from January 2006 to December 2015, 170 patients drawn by stratified randomization were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of plasma galactose-deficient IgA1 (Gd-IgA1) and antiglycan autoantibody (IgG and IgA1). The correlation between antiglycan autoantibodies and clinicopathological parameters was analyzed by linear correlation and multiple linear regression analysis. The receiver operating characteristic curve (ROC) was used to evaluate the value of plasma anti glycide antibodies in the diagnosis of IgAN. Results IgG and IgA1 antiglycan autoantibodies that specifically recognized Fab-hinge region (Fab-HR) antigens could be detected in both IgAN and healthy control group. Agglutinin inhibition test showed that the specific antigen epitope was N-acetylgalactosamine (GalNAc) residue exposed to galactose deficiency in IgA1 hinged region. There was no significant difference in the absolute levels of plasma IgG antiglycan autoantibodies between IgAN and healthy controls (P=0.963). After adjustment of the plasma level of IgG, the normalized antiglycan autoantibody (ln[IgG antiglycan antibody/IgG]) in patients with IgAN was significantly higher than that in healthy controls (0.58±0.31 vs 0.37±0.11, P﹤0.01). The normalized level of IgG antiglycan autoantibody in IgAN patients was positively correlated with 24 h urine protein level during renal biopsy (Spearman r=0.183, P﹤0.05), and was also significantly correlated with 24 h urinary protein level after adjusting for baseline clinical and pathological factors (β=0.713, 95%CI 0.323-1.102, P﹤0.01). The area under ROC curve (AUC) of normalized IgG antiglycan autoantibody in the diagnosis of IgAN was 0.764 (95% CI 0.682-0.845, P﹤0.05). Using the cut-off value of 0.396, the sensitivity and specificity of normalized IgG antiglycan autoantibody for IgAN were 0.729 and 0.700 respectively. There was no significant difference in the absolute or normalized levels of IgA1 antiglycan autoantibodies between IgAN patients and healthy controls. Conclusions Gd-IgA1-specific antiglycan autoantibodies can be detected both in IgAN patients and healthy controls. They are elevated in some patients with IgAN and possibly involved in the development of IgAN.