全文获取类型
收费全文 | 551篇 |
免费 | 21篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 60篇 |
妇产科学 | 4篇 |
基础医学 | 41篇 |
口腔科学 | 14篇 |
临床医学 | 41篇 |
内科学 | 117篇 |
皮肤病学 | 5篇 |
神经病学 | 34篇 |
特种医学 | 158篇 |
外科学 | 30篇 |
综合类 | 8篇 |
预防医学 | 23篇 |
眼科学 | 3篇 |
药学 | 22篇 |
中国医学 | 1篇 |
肿瘤学 | 18篇 |
出版年
2021年 | 4篇 |
2020年 | 7篇 |
2019年 | 2篇 |
2018年 | 6篇 |
2017年 | 2篇 |
2015年 | 7篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 9篇 |
2011年 | 12篇 |
2010年 | 20篇 |
2009年 | 11篇 |
2008年 | 8篇 |
2007年 | 15篇 |
2006年 | 14篇 |
2005年 | 10篇 |
2004年 | 12篇 |
2003年 | 13篇 |
2002年 | 12篇 |
2001年 | 11篇 |
2000年 | 6篇 |
1999年 | 11篇 |
1998年 | 32篇 |
1997年 | 27篇 |
1996年 | 27篇 |
1995年 | 26篇 |
1994年 | 17篇 |
1993年 | 19篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 16篇 |
1988年 | 18篇 |
1987年 | 19篇 |
1986年 | 14篇 |
1985年 | 23篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 23篇 |
1981年 | 9篇 |
1980年 | 15篇 |
1979年 | 1篇 |
1978年 | 6篇 |
1977年 | 12篇 |
1976年 | 13篇 |
1975年 | 6篇 |
1974年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有579条查询结果,搜索用时 31 毫秒
1.
Rob NM Weijers 《World journal of diabetes》2020,11(5):165-181
ResearchGate is a world wide web for scientists and researchers to share papers, ask and answer questions, and find collaborators. As one of the more than 15 million members, the author uploads research output and reads and responds to some of the questions raised, which are related to type 2 diabetes. In that way, he noticed a serious gap of knowledge of this disease among medical professionals over recent decades. The main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology, which can be helpful for the scientific understanding of the molecular nature of type 2 diabetes. To fill up the shortcomings in the curricula of medical education, and to familiarize the medical community with a new concept of the onset of type 2 diabetes, items are discussed like: Insulin resistance, glucose effectiveness, insulin sensitivity, cell membranes, membrane flexibility, unsaturation index (UI; number of carbon-carbon double bonds per 100 acyl chains of membrane phospholipids), slow-down principle, effects of temperature acclimation on phospholipid membrane composition, free fatty acids, energy transport, onset of type 2 diabetes, metformin, and exercise. Based on the reviewed data, a new model is presented with proposed steps in the development of type 2 diabetes, a disease arising as a result of a hypothetical hereditary anomaly, which causes hyperthermia in and around the mitochondria. Hyperthermia is counterbalanced by the slow-down principle, which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl chains. The accompanying reduction in the UI lowers membrane flexibility, promotes a redistribution of the lateral pressure in cell membranes, and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT proteins. These events will set up a reduction in transmembrane glucose transport. So, a new blood glucose regulation system, effective in type 2 diabetes and its prediabetic phase, is based on variations in the acyl composition of phospholipids and operates independent of changes in insulin and glucose concentration. UI assessment is currently arising as a promising analytical technology for a membrane flexibility analysis. An increase in mitochondrial heat production plays a pivotal role in the existence of this regulation system. 相似文献
2.
B Gerdts AFPM Vloemans RW Kreis 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):781-788
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe and potentially fatal drug reaction characterized by an extensive skin rash with blisters and exfoliation, frequently accompanied by mucositis. The wounds caused by TEN are similar to second-degree burns and severe cases may involve large areas of skin loss. OBJECTIVES: Analysis of our results in patients with TEN and evaluation of the variety of therapeutic interventions that has been studied and suggested in TEN. PATIENTS/METHODS: Retrospective analysis of 19 consecutive patients with TEN treated in our burns centre between 1989 and 2004. RESULTS: Immediate withdrawal of any potentially fatal drug, maximum supportive care, and a restricted and tailored antibiotic, medical and surgical treatment regimen confined mortality to 21%, whereas prognosis scores like APACHE II and SCORTEN predicted mortality of 22 and 30%, respectively. A positive contribution of selective digestive decontamination is suggested but has yet to be established. CONCLUSIONS: Because of a potentially fatal outcome, fast referral of a patient suspected of TEN to a specialized centre (mostly a burns unit or specialized dermatology centre) for expert wound management and tailored comprehensive care is strongly advised and contributes to survival. 相似文献
3.
1背景 育龄妇女常见慢性下腹痛,可造成身体损害、情绪忧伤及导致巨大的健康服务费用。美国在这方面的花费超过8亿8千万美元(Mathias 1996)。英国全国数据库的一般性诊治资料显示,慢性下腹痛发病率及流行率与偏头痛、背部痛、哮喘发病率相似(Zondervan 1999)。 相似文献
4.
5.
6.
7.
8.
9.
10.
Dou Q; Tarnuzzer RW; Williams RS; Schultz GS; Chegini N 《Molecular human reproduction》1997,3(11):1005-1014