排序方式: 共有16条查询结果,搜索用时 0 毫秒
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Suchai Sritippayawan Sombat Borvornpadungkitti Atchara Paemanee Chagkrapan Predanon Wattanachai Susaengrat Duangporn Chuawattana Nunghathai Sawasdee Sirintra Nakjang Suttikarn Pongtepaditep Choochai Nettuwakul Nanyawan Rungroj Somkiat Vasuvattakul Prida Malasit Pa-thai Yenchitsomanus 《Urological research》2009,37(3):141-146
Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population.
Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects
including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney–ureter–bladder (KUB)
and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members
(21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (λR) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about
88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic
factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated
with the disease. 相似文献
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Taesotikul T Dumrongsakulchai W Wattanachai N Navinpipat V Somanabandhu A Tassaneeyakul W Tassaneeyakul W 《Drug metabolism and pharmacokinetics》2011,26(2):154-161
Phyllanthus amarus has long been used as a herbal medicine in several countries. Phytochemicals in herbal medicine may interact with cytochromes P450 (CYP) and thus raise the potential of herb-drug interactions; therefore, the inhibitory effects of P. amarus and its major phytochemicals phyllanthin and hypophyllanthin on CYP isoforms were determined using human liver microsomes and selective substrates. Both ethanolic and aqueous extracts of P. amarus inhibited CYP1A2, CYP2D6, CYP2E1 and CYP3A4 in a dose-dependent manner. Compared to known CYP3A inhibitors, the IC(50) values of the ethanolic and aqueous extracts on testosterone 6β-hydroxylation were higher than that of ketoconazole but were lower than those of erythromycin and clarithromycin. Both extracts were weak inhibitors of CYP1A2, CYP2D6 and CYP2E1. In addition, phyllanthin and hypophyllanthin were potent mechanism-based inhibitors of CYP3A4 with K(I) values of 1.75 ± 1.20 μM and 2.24 ± 1.84 μM and k(inact) values of 0.18 ± 0.05 min(-1) and 0.15 ± 0.06 min(-1), respectively. The k(inact)/K(I) ratios of these lignans were higher than those reported for some therapeutic drugs that act as mechanism-based inhibitors of CYP3A4. These results suggest that co-administration of P. amarus with drugs that are metabolized by CYP3A4 may potentially result in herb-drug interactions. 相似文献
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Wattanachai Chotinaiwattarakul Praveen Dayalu Ronald D. Chervin Roger L. Albin 《Sleep & breathing》2011,15(3):471-478
Objective
The objective of this study is to assess the risk of sleep-disordered breathing (SDB) in patients with Parkinson's disease (PD) in a cross-sectional survey of PD subjects and controls in a university-based movement disorders clinic. 相似文献6.
Chanchamroen S Kewcharoenwong C Susaengrat W Ato M Lertmemongkolchai G 《Infection and immunity》2009,77(1):456-463
The major predisposing factor for melioidosis is diabetes mellitus, but no immunological mechanisms have been investigated to explain this. In this study, polymorphonuclear neutrophil (PMN) responses to Burkholderia pseudomallei, the causative agent of melioidosis, in healthy and diabetic Thai subjects were determined by flow cytometry. The results showed that B. pseudomallei displayed reduced uptake by PMNs compared to Salmonella enterica serovar Typhimurium and Escherichia coli. Additionally, intracellular survival of B. pseudomallei was detected throughout a 24-h period, indicating the intrinsic resistance of B. pseudomallei to killing by PMNs. Moreover, PMNs from diabetic subjects displayed impaired phagocytosis of B. pseudomallei, reduced migration in response to interleukin-8, and an inability to delay apoptosis. These data show that B. pseudomallei is intrinsically resistant to phagocytosis and killing by PMNs. These observations, together with the impaired migration and apoptosis in diabetes mellitus, may explain host susceptibility in melioidosis. 相似文献
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Wattanachai N Tassaneeyakul W Rowland A Elliot DJ Bowalgaha K Knights KM Miners JO 《Drug metabolism and disposition》2012,40(5):982-989
Long-chain unsaturated fatty acids inhibit several cytochrome P450 and UDP-glucuronosyltransferase (UGT) enzymes involved in drug metabolism, including CYP2C8, CYP2C9, UGT1A9, UGT2B4, and UGT2B7. Bovine serum albumin (BSA) enhances these cytochrome P450 and UGT activities by sequestering fatty acids that are released from membranes, especially with human liver microsomes (HLM) as the enzyme source. Here, we report the effects of BSA on CYP1A2-catalyzed phenacetin (PHEN) O-deethylation and lidocaine (LID) N-deethylation using HLM and Escherichia coli-expressed recombinant human CYP1A2 (rCYP1A2) as the enzyme sources. BSA (2% w/v) reduced (p < 0.05) the K(m) values of the high-affinity components of human liver microsomal PHEN and LID deethylation by approximately 70%, without affecting V(max). The K(m) (or S(50)) values for PHEN and LID deethylation by rCYP1A2 were reduced to a similar extent. A fatty acid mixture, comprising 3 μM concentrations each of oleic acid and linoleic acid plus 1.5 μM arachidonic acid, doubled the K(m) value for PHEN O-deethylation by rCYP1A2. Inhibition was reversed by the addition of BSA. K(i) values for the individual fatty acids ranged from 4.7 to 16.7 μM. Single-point in vitro-in vivo extrapolation (IV-IVE) based on the human liver microsomal kinetic parameters obtained in the presence, but not absence, of BSA predicted in vivo hepatic clearances of PHEN O-deethylation and LID N-deethylation that were comparable to values reported in humans, although in vivo intrinsic clearances were underpredicted. Prediction of the in vivo clearances of the CYP1A2 substrates observed here represents an improvement on other experimental systems used for IV-IVE. 相似文献
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Banhiran W Assanasen P Metheetrairut C Nopmaneejumruslers C Chotinaiwattarakul W Kerdnoppakhun J 《Sleep & breathing》2012,16(3):663-675