全文获取类型
收费全文 | 7961篇 |
免费 | 456篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 121篇 |
妇产科学 | 158篇 |
基础医学 | 1205篇 |
口腔科学 | 71篇 |
临床医学 | 776篇 |
内科学 | 1395篇 |
皮肤病学 | 185篇 |
神经病学 | 934篇 |
特种医学 | 394篇 |
外科学 | 1394篇 |
综合类 | 25篇 |
一般理论 | 1篇 |
预防医学 | 280篇 |
眼科学 | 109篇 |
药学 | 554篇 |
中国医学 | 8篇 |
肿瘤学 | 798篇 |
出版年
2023年 | 35篇 |
2022年 | 64篇 |
2021年 | 99篇 |
2020年 | 82篇 |
2019年 | 113篇 |
2018年 | 144篇 |
2017年 | 131篇 |
2016年 | 174篇 |
2015年 | 171篇 |
2014年 | 233篇 |
2013年 | 301篇 |
2012年 | 416篇 |
2011年 | 519篇 |
2010年 | 303篇 |
2009年 | 308篇 |
2008年 | 501篇 |
2007年 | 545篇 |
2006年 | 523篇 |
2005年 | 546篇 |
2004年 | 512篇 |
2003年 | 522篇 |
2002年 | 439篇 |
2001年 | 157篇 |
2000年 | 118篇 |
1999年 | 125篇 |
1998年 | 122篇 |
1997年 | 97篇 |
1996年 | 64篇 |
1995年 | 57篇 |
1994年 | 57篇 |
1993年 | 56篇 |
1992年 | 45篇 |
1991年 | 43篇 |
1990年 | 39篇 |
1989年 | 50篇 |
1988年 | 45篇 |
1987年 | 27篇 |
1986年 | 27篇 |
1985年 | 40篇 |
1984年 | 30篇 |
1983年 | 24篇 |
1982年 | 28篇 |
1981年 | 26篇 |
1980年 | 22篇 |
1979年 | 37篇 |
1978年 | 27篇 |
1977年 | 37篇 |
1976年 | 33篇 |
1975年 | 23篇 |
1974年 | 23篇 |
排序方式: 共有8450条查询结果,搜索用时 15 毫秒
1.
Mt D. Dbrssy Chockalingam Ramanathan Danesh Ashouri Vajari Yixin Tong Thomas Schlaepfer Volker A. Coenen 《The European journal of neuroscience》2021,53(1):89-113
Deep brain stimulation (DBS) in psychiatric illnesses has been clinically tested over the past 20 years. The clinical application of DBS to the superolateral branch of the medial forebrain bundle in treatment‐resistant depressed patients—one of several targets under investigation—has shown to be promising in a number of uncontrolled open label trials. However, there are remain numerous questions that need to be investigated to understand and optimize the clinical use of DBS in depression, including, for example, the relationship between the symptoms, the biological substrates/projections and the stimulation itself. In the context of precision and customized medicine, the current paper focuses on clinical and experimental research of medial forebrain bundle DBS in depression or in animal models of depression, demonstrating how clinical and scientific progress can work in tandem to test the therapeutic value and investigate the mechanisms of this experimental treatment. As one of the hypotheses is that depression engenders changes in the reward and motivational networks, the review looks at how stimulation of the medial forebrain bundle impacts the dopaminergic system. 相似文献
2.
3.
Oliver Sartor MD Daniel Heinrich MD Neil Mariados MD Maria José Méndez Vidal MD Daniel Keizman MD Camilla Thellenberg Karlsson MD Avivit Peer MD Giuseppe Procopio MD Stephen J. Frank MD Kalevi Pulkkanen MD Eli Rosenbaum MD Stefano Severi MD José Trigo MD Lucia Trandafir MD Volker Wagner MD Rui Li MS Luke T. Nordquist MD 《The Prostate》2019,79(14):1683-1691
4.
5.
Lucia Nogovà MD Volker Diehl MD Andreas Engert MD 《Current hematologic malignancy reports》2006,1(1):60-65
Lymphocyte-predominant Hodgkin’s lymphoma (LPHL) differs in histologic and clinical presentation from classical Hodgkin’s
lymphoma (cHL). Treatment of LPHL patients using standard Hodgkin’s lymphoma protocols leads to complete remission in more
than 95% of patients. Survival and freedom from treatment failure are substantially worse in advanced-stage patients than
for early-stage patients. Thus, patients in advanced stages and those in early stages with unfavorable risk factors should
be treated similar to those with cHL. In contrast, patients with early-stage LPHL without risk factors might be sufficiently
treated with reduced-intensity programs having less severe adverse effects. As a result, treatment of early LPHL is rather
heterogeneous, including radiotherapy using extended-fleld technique, involved-fleld radiotherapy (IF-RT), combined-modality
treatment, and, more recently, monoclonal antibodies. Watch-and-wait strategy plays an important role in pediatric oncology,
to avoid adverse effects associated with therapy. IF-RT seems to be emerging as a treatment of choice for patients with stage
IA LPHL; most larger study groups, such as the German Hodgkin Study Group and the European Organisation for Research and Treatment
of Cancer, have adopted IF-RT as the treatment of choice for these patients. 相似文献
6.
We evaluated the acquisition and performance of a high-precision locomotor task in patients with Parkinson's disease (PD) and healthy subjects. All subjects walked on a treadmill and had to step repetitively as low as possible over an obstacle without touching it. During blocks 1 and 2, the subjects had full vision and received additional acoustic warning and feedback signals. During block 3, vision became restricted. Changes in foot clearance and the number of obstacle hits were evaluated. Initially, PD patients performed poorer and improved foot clearance slower. After task repetition, the groups performed similarly. Restricting vision deteriorated performance in both groups. The similar performance of PD patients after task repetition might indicate that adequate training could improve adaptive locomotor behavior in PD patients. 相似文献
7.
James R. Westphal 《International journal of mental health and addiction》2007,5(2):123-140
Introduction Recent reviews found problem gamblers are heterogeneous and recommended subtyping gamblers in treatment studies.
Objective Review factors (stage of change, preferred gambling activity, co-occurring disorder, and temporal instability of symptoms)
for subtyping by evaluating the evidence for their effects on gambling treatment.
Methods Literature review, evidence grading.
Results Evidence is limited that any of the reviewed factors affects gambling treatment. Substantial evidence from prospective studies
and other evidence from cross-sectional studies and the strong placebo response among pathological gamblers support the temporal
instability of gambling symptoms.
Conclusions Multiple studies are needed to develop the evidence base needed to subtype gamblers in treatment. Changes in the diagnostic
criteria of pathological gambling may be necessary, especially to specify the persistence of gambling-related symptoms. 相似文献
9.
Anneloes Dirks Lucianne Groenink Koen G C Westphal Jocelien D A Olivier P Monika Verdouw Jan van der Gugten Mark A Geyer Berend Olivier 《Neuropsychopharmacology》2003,28(10):1790-1798
Chronically elevated levels of corticotropin-releasing factor (CRF) in transgenic mice overexpressing CRF in the brain (CRF-OE) appear to be associated with alterations commonly associated with major depressive disorder, as well as with sensorimotor gating deficits commonly associated with schizophrenia. In the present study, we tested the hypothesis that antipsychotics may be effective in normalizing prepulse inhibition (PPI) of acoustic startle in CRF-OE mice, which display impaired sensorimotor gating compared to wild-type (WT) mice. The typical antipsychotic haloperidol and atypical antipsychotic risperidone improved PPI in the CRF-OE mice, but were ineffective in WT mice. The atypical antipsychotic clozapine did not influence PPI in CRF-OE mice, but reduced gating in WT mice. This effect of clozapine in the CRF-OE mice may thus be regarded as a relative improvement, consistent with the observed effect of haloperidol and risperidone. As expected, the anxiolytic, nonantipsychotic chlordiazepoxide was devoid of any effect. All four compounds dose-dependently reduced the acoustic startle response irrespective of genotype. These results indicate that antipsychotic drugs are effective in improving startle gating deficits in the CRF-OE mice. Hence, the CRF-OE mouse model may represent an animal model for certain aspects of psychotic depression, and could be a valuable tool for research addressing the impact of chronically elevated levels of CRF on information processing. 相似文献
10.
Uta Kraus-Tiefenbacher Lelia Bauer Antonella Scheda Carola Schoeber Joerg Schaefer Volker Steil Frederik Wenz 《BMC cancer》2007,7(1):178