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排序方式: 共有225条查询结果,搜索用时 125 毫秒
1.
Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? 总被引:5,自引:0,他引:5
Biagi F Luinetti O Campanella J Klersy C Zambelli C Villanacci V Lanzini A Corazza GR 《Journal of clinical pathology》2004,57(8):835-839
BACKGROUND: The counting of intraepithelial lymphocytes (IELs) in the villous tips of architecturally normal small bowel biopsy specimens was proposed as a method to measure mucosal infiltration in gluten sensitive patients. AIMS: To apply this straightforward method in duodenal biopsy specimens from patients affected by potential coeliac disease (PCD) to verify whether it can discriminate these patients from controls. METHODS: Paraffin wax embedded duodenal sections from 11 patients affected by PCD were stained with an antihuman CD3 antibody. Sections from 19 patients affected by treated coeliac disease (TCD) and 17 patients in whom coeliac disease was excluded were stained with the same antibody to serve as controls. The slides were examined blindly. IELs/20 enterocytes in five randomly chosen villous tips were counted. Patients affected by PCD were all on a gluten containing diet. They had an architecturally normal duodenal mucosa and were positive for endomysial antibody. Both TCD and non-coeliac controls were negative for endomysial antibody. RESULTS: The mean villous tip IEL scores were 4.6 (SD, 1.5; range, 1.4-7.8) in non-coeliac controls, 7.9 (SD, 4.0; range, 2.0-18.6) in TCD, and 9.2 (SD, 4.7; range, 5.8-21.8) in patients with PCD. The difference between PCD and non-coeliac controls was significant. CONCLUSIONS: This is a very simple and sufficiently reliable method to count IELs. In patients with an architecturally normal duodenal mucosa, the IEL count in villous tips helps to distinguish between patients with PCD and non-coeliac controls. 相似文献
2.
Vincenzo Villanacci Silvia Cristina Maurizio Muscarà Silvia Saettone Laura Broglia Elisabetta Antonelli Marianna Salemme Pietro Occhipinti Gabrio Bassotti 《Pathology, research and practice》2013
Pseudomembranous collagenous colitis is a rare pathological condition, not related to infectious agents, and characterized by thickening of the subepithelial collagen and formation of pseudomembranes. We report one such case, which responded to budesonide treatment after failures of previous approaches given, being unaware of the correct diagnosis. 相似文献
3.
Histopathological evaluation of duodenal biopsy in the PreventCD project. An observational interobserver agreement study 下载免费PDF全文
Vincenzo Villanacci Luisa Lorenzi Francesco Donato Renata Auricchio Piotr Dziechciarz Judit Gyimesi Sibylle Koletzko Zrinjka Mišak Vanesa Morente Laguna Isabel Polanco David Ramos Raanan Shamir Riccardo Troncone Sabine L. Vriezinga M. Luisa Mearin 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2018,126(3):208-214
Aim of the current study was to evaluate the inter‐observer agreement between pathologists in the diagnosis of celiac disease (CD), in the qualified context of a multicenter study. Biopsies from the “PreventCD” study, a multinational‐ prospective‐ randomized study in children with at least one‐first‐degree relative with CD and positive for HLA‐DQ2/HLA‐DQ8. Ninety‐eight biopsies were evaluated. Considering diagnostic samples with villous atrophy (VA), the agreement was satisfactory (κ = 0.84), but much less when assessing the severity of these lesions. The use of the recently proposed Corazza‐Villanacci classification showed a moderately higher level of agreement (κ = 0.39) than using the Marsh‐Oberhuber system (κ = 0.31). 57.1% of cases were considered correctly oriented. A number of >4 samples per patient was statistically associated to a better agreement; orientation did not impact on κ values. Agreement results in this study appear more satisfactory than in previous papers and this is justified by the involvement of centers with experience in CD diagnosis and by the well‐controlled setting. Despite this, the reproducibility was far from optimal with a poor agreement in grading the severity of VA. Our results stress the need of a minimum of four samples to be assessed by the pathologist. 相似文献
4.
Randomised clinical study: gluten challenge induces symptom recurrence in only a minority of patients who meet clinical criteria for non‐coeliac gluten sensitivity 下载免费PDF全文
5.
Caputo A. Parente P. Cadei M. Fassan M. Rispo A. Leoncini G. Bassotti G. Del Sordo R. Metelli C. Daperno M. Armuzzi A. Villanacci V. 《Techniques in coloproctology》2022,26(9):713-723
Techniques in Coloproctology - Assessment of mucosal healing is important for the management of patients with inflammatory bowel disease (IBD), but endoscopy can miss microscopic disease areas that... 相似文献
6.
Bassotti G Villanacci V Nascimbeni R Cadei M Manenti S Antonelli E Fanini L Salerni B 《Digestive diseases and sciences》2012,57(1):65-71
Background
Mast cells are involved in visceral hypersensitivity and motor activity of the gastrointestinal tract. However, there is almost no information concerning mast cells in constipated patients. 相似文献7.
8.
Raffaele Manta Marzio Frazzoni Rita Conigliaro Livia Maccio Gianlugi Melotti Emanuele Dabizzi Helga Bertani Mauro Manno Danilo Castellani Vincenzo Villanacci Gabrio Bassotti 《Surgical endoscopy》2013,27(5):1569-1572
Background
SpyGlass® single-operator peroral cholangioscopy appears to be a promising technique to overcome some limitations of conventional peroral cholangioscopy. We aimed to prospectively evaluate the SpyGlass system in a cohort of patients with indeterminate biliary lesions.Methods
Patients with indeterminate strictures or filling defects at endoscopic retrograde cholangiopancreatography (ERCP) were consecutively enrolled. After SpyGlass visual evaluation, targeted biopsies were taken with the SpyBite® and histopathological assessment was made by two experienced gastrointestinal pathologists. SpyBite-targeted biopsy results were evaluated by assessing agreement with surgical specimens and by evaluation of final, clinical follow-up-based diagnosis.Results
Fifty-two patients participated in the study. In 7 cases, definite diagnosis (stones, varices) was made by SpyGlass endoscopic evaluation. In 42 of the remaining 45 cases, material suitable for histopathology assessment was provided by the SpyBite. Overall, a definite diagnosis was made in 49 (7 + 42; 94 %) cases. Agreement of SpyBite biopsy results with surgical specimen diagnosis was found in 38/42 (90 %) cases; sensitivity, specificity, and positive and negative predictive values were 88, 94, 96, and 85 %, respectively. Procedure-related complications consisted of one case of mild cholangitis and one case of mild pancreatitis.Conclusions
In our series, the SpyGlass system allowed adequate biopsy sampling and definite diagnosis with high accuracy in the vast majority of patients with indeterminate biliary lesions. Its use was associated with a low complication rate. Further refinements of the technique are warranted, but the SpyGlass system has the potential to become a diagnostic standard for the assessment of indeterminate biliary lesions. 相似文献9.
10.
The authors describe a case of acute appendicitis associated "serrated" adenoma (SA). to the histological finding of a SA is a colorectal pre-cancerous lesion which presents the morphological and architectural characteristics of hyperplasic polyps, combined with aspects of adenomatous dysplasia. SA can eventually evolve into a malignant cancer, similarly to classic adenomatous polyps. Clinical and pathological aspects of this lesion are hereby analysed, with respect to recent Literature data. 相似文献