全文获取类型
收费全文 | 8922篇 |
免费 | 629篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 72篇 |
儿科学 | 285篇 |
妇产科学 | 417篇 |
基础医学 | 1108篇 |
口腔科学 | 220篇 |
临床医学 | 1334篇 |
内科学 | 1522篇 |
皮肤病学 | 131篇 |
神经病学 | 662篇 |
特种医学 | 195篇 |
外科学 | 1068篇 |
综合类 | 212篇 |
一般理论 | 4篇 |
预防医学 | 717篇 |
眼科学 | 226篇 |
药学 | 676篇 |
中国医学 | 91篇 |
肿瘤学 | 653篇 |
出版年
2023年 | 62篇 |
2022年 | 71篇 |
2021年 | 214篇 |
2020年 | 132篇 |
2019年 | 205篇 |
2018年 | 262篇 |
2017年 | 189篇 |
2016年 | 214篇 |
2015年 | 261篇 |
2014年 | 290篇 |
2013年 | 461篇 |
2012年 | 715篇 |
2011年 | 685篇 |
2010年 | 370篇 |
2009年 | 342篇 |
2008年 | 601篇 |
2007年 | 540篇 |
2006年 | 562篇 |
2005年 | 483篇 |
2004年 | 449篇 |
2003年 | 406篇 |
2002年 | 341篇 |
2001年 | 192篇 |
2000年 | 210篇 |
1999年 | 151篇 |
1998年 | 71篇 |
1997年 | 69篇 |
1996年 | 49篇 |
1995年 | 39篇 |
1994年 | 42篇 |
1993年 | 33篇 |
1992年 | 127篇 |
1991年 | 92篇 |
1990年 | 91篇 |
1989年 | 71篇 |
1988年 | 71篇 |
1987年 | 51篇 |
1986年 | 46篇 |
1985年 | 52篇 |
1984年 | 45篇 |
1983年 | 27篇 |
1982年 | 29篇 |
1981年 | 20篇 |
1980年 | 15篇 |
1979年 | 19篇 |
1978年 | 16篇 |
1977年 | 12篇 |
1976年 | 10篇 |
1971年 | 13篇 |
1970年 | 12篇 |
排序方式: 共有9593条查询结果,搜索用时 531 毫秒
1.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
2.
Matrine,oxymatrine, and compound Kushen injection from the roots of Sophora flavescens: an overview of their anticancer activities
下载免费PDF全文
![点击此处可从《中国药学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In the present review, we updated current information on the chemistry, contents, and anticancer properties of matrine (MT), oxymatrine (OMT), and compound Kushen injection (CKI). The anticancer properties were focused on lung, breast, and liver cancer cells because they are most susceptible. Sources of information were from Google, Google Scholar, PubMed, PubMed Central, Science Direct, PubChem, J-Stage, Directory of Open Access Journals (DOAJ), and China National Knowledge Infrastructure (CNKI). Reference was also made on botanical websites, such as Flora of China and World Flora Online. MT and OMT are dominant quinolizidine alkaloids from the roots of Sophora flavescens (Kushen) of the family Fabaceae. Against lung, breast, and liver cancer cells, MT and OMT inhibit cell proliferation; induce cell cycle arrest, apoptosis, and autophagy; restrict angiogenesis; and inhibit cell metastasis, invasion, and migration. The processes involve various molecular targets and signaling pathways. CKI is a traditional Chinese medicine (TCM) composed of root extracts of S. flavescens and Smilax glabra (Baituling) of the family Smilacaceae. With MT and OMT as major components, CKI has been approved for the treatment of cancer in China more than 20 years ago. In recent years, systematic reviews and meta-analysis have been undertaken to evaluate the anticancer effects of CKI. When CKI is used alone and in combination with chemotherapy of western medicine, there is much to be learned concerning their interactions besides their individual and integrated efficacy. Some perspectives of MT, OMT, and CKI are discussed, and their suggestions for future research are provided. 相似文献
3.
Chien-Hua Tseng Ben-Jei Tsuang Chun-Ju Chiang Kai-Chen Ku Jeng-Sen Tseng Tsung-Ying Yang Kuo-Hsuan Hsu Kun-Chieh Chen Sung-Liang Yu Wen-Chung Lee Tsang-Wu Liu Chang-Chuan Chan Gee-Chen Chang 《Journal of thoracic oncology》2019,14(5):784-792
Introduction
For never-smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between Northern Taiwan (NT) and Southern Taiwan (ST).Methods
We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non-AdLC. Two subsets were selected to assess different AdLC stage trends and the effect of PM2.5 on survival of patients with AdLC.Results
From 1995 to 2015, the proportion of male adult ever-smokers decreased from 59.4% to 29.9% whereas the female smoking rate remained low (3.2% to 5.3%). AdLC incidence in males and females increased from 9.06 to 23.25 and 7.05 to 24.22 per 100,000 population, respectively. Since 1993, atmospheric visibility in NT improved (from 7.6 to 11.5 km), but deteriorated in ST (from 16.3 to 4.2 km). The annual percent change in AdLC stages IB to IV was 0.3% since 2009 (95% confidence interval [CI]: -1.9%–2.6%) in NT, and 4.6% since 2007 (95% CI: 3.3%–5.8%) in ST; 53% patients with LC had never smoked. Five-year survival rates for never-smokers, those with EGFR wild-type genes, and female patients with AdLC were 12.6% in NT and 4.5% in ST (hazard ratio: 0.79, 95% CI: 0.70–0.90).Conclusions
In Taiwan, greater than 50% of patients with LC had never smoked. PM2.5 level changes can affect AdLC incidence and patient survival. 相似文献4.
5.
Kalaichelvi Ganesalingam Ann Sanson Vicki Anderson Keith Owen Yeates 《Journal of the International Neuropsychological Society》2006,12(5):609-621
This study examined the impact of childhood traumatic brain injury (TBI) on self-regulation and social and behavioral functioning, and the role of self-regulation as a predictor of children's social and behavioral functioning. Participants included 65 children with moderate to severe TBI and 65 children without TBI, all between 6 and 11 years of age. Self-regulation and social and behavioral functioning were assessed 2 to 5 years following injury. Children with TBI displayed deficits in self-regulation and social and behavioral functioning, after controlling for socioeconomic status (SES), although the magnitude of the deficits was not related to injury severity. Self-regulation accounted for significant variance in children's social and behavioral functioning, after controlling for SES and group membership. Self-regulation may be an important determinant of children's social and behavioral functioning following TBI. 相似文献
6.
7.
While balloon valvuloplasty has been widely used for the treatment of congenital valvular pulmonary stenosis (PS) in children and adults, its use in elderly patients is less common. An 80-year-old woman with congenital valvular PS received valvuloplasty with double-balloon technique. Right ventricle systolic pressure and pulmonary valve systolic pressure gradient decreased from 95 to 44 mm Hg and from 75 to 35 mm Hg, respectively. Follow-up Doppler echocardiography 2 months later showed further decrease in the transvalvular systolic pressure gradient to 29 mm Hg. The patient had symptomatic relief, and no major complication was noted. Balloon pulmonary valvuloplasty can be an effective treatment for elderly patients with congenital valvular PS. 相似文献
8.
John Nietupski Terry McQuillen Deana Duncan Berg Judy Weyant Vicki Daugherty Stephanie Bildstein Amber O'Connor Judy Warth Susan M. Hamre-Nietupski 《Journal of developmental and physical disabilities》2004,16(2):179-192
This paper describes an innovative approach to preparing high school students with mild disabilities for challenging careers in high tech industries, called High School High Tech (HSHT). Iowa's HSHT Goes to College program has three central elements, each of which is discussed in this paper: High School Preparation—assisting students in identifying a suitable high tech career goal; Higher Education Preparation and Supports—assisting students in selecting college/training programs that match their career goal, and in successfully completing their postsecondary programs; Workforce Entry Assistance—linking students with employers and launching their high tech careers. The paper concludes with a presentation of outcomes to date and recommendations for program enhancements. The information presented here is intended to assist education and rehabilitation professionals interested in establishing similar efforts across the nation. 相似文献
9.
10.