Idiopathic neonatal pleural effusion

We present two cases of neonatal pleural effusion, a relatively rare condition, most commonly due to chylothorax. One had bilateral hypoplastic lungs and the other suffered birth asphyxia. Both died before any treatment could be initiated.     

Role of levamisole immunotherapy as an adjuvant to radiotherapy in oral cancer. II. Lymphocyte subpopulations

The effect of radiotherapy and adjuvant levamisole immunotherapy on the lymphocyte subpopulations was investigated. Comparisons were made between the groups receiving levamisole, those receiving placebo and normal healthy controls. Results of a thirty-month follow-up are reported. Radiotherapy caused leukopenia and lymphopenia affecting all the subsets (T, B, TG, and TM), T lymphocytes were affected to a greater extent. This study demonstrates that levamisole does hasten the restoration of T lymphocytes, with the TM lymphocytes showing a faster repopulation in comparison to the TG lymphocytes.     

Presence of a receptor for the active component of Iscador in ascites fluid of tumour bearing mice

Tumour bearing mice exhibit a specific "receptor" in the ascites fluid which binds with the active component isolated from Iscador. This "receptor" was found to be a protein which inhibited the cytotoxicity of Iscador and its isolated active component at low concentration. The receptor protein was also found in the sonicates of tumour cells which are susceptible to the action of Iscador but not in lymphocytes which were not susceptible to Iscador or its isolated active component. The receptor was separated on a Sephadex G-50 column. Activity was lost upon heat denaturation and dialysis.     

p-Amino salicylic acid — oxidized cellulose system: a model for long term drug delivery

The immobilization of p-amino salicylic acid (PASA) on periodic oxidized cellulose (O.C) as a biocompatible carrier was investigated. The immobilization of the PASA is based on Schiff's base formation between the amino group of PASA and the aldehyde group of O.C. The in vivo and in vitro release of p-amino salicylic acid was studied. Such a system may be useful for the sustained delivery of the drugs in the body, since O.C. itself is a biosoluble carrier.     

Biodegradation studies on periodate oxidized cellulose

Sodium periodate oxidized cellulose was found to degrade into small molecules when implanted subcutaneously in rats. Thus the potentiality of using oxidized cellulose as a biodegradable drug carrier is envisaged.     

A breast lump that scares a doctor and the patient equally: unexpected and complicated surgical consequences of long-standing diabetes

Journal of Public Health - This study analyzes a number of diabetic mastopathy cases in long-standing type 1 diabetes to obtain a detailed history and examination findings from these patients and...