全文获取类型
收费全文 | 708717篇 |
免费 | 35730篇 |
国内免费 | 1000篇 |
专业分类
耳鼻咽喉 | 9289篇 |
儿科学 | 22541篇 |
妇产科学 | 16932篇 |
基础医学 | 117065篇 |
口腔科学 | 18498篇 |
临床医学 | 60467篇 |
内科学 | 137905篇 |
皮肤病学 | 17723篇 |
神经病学 | 48789篇 |
特种医学 | 23836篇 |
外国民族医学 | 83篇 |
外科学 | 100192篇 |
综合类 | 8581篇 |
现状与发展 | 2篇 |
一般理论 | 154篇 |
预防医学 | 55717篇 |
眼科学 | 15607篇 |
药学 | 53595篇 |
1篇 | |
中国医学 | 1872篇 |
肿瘤学 | 36598篇 |
出版年
2021年 | 8062篇 |
2019年 | 8031篇 |
2018年 | 11586篇 |
2017年 | 7751篇 |
2016年 | 8459篇 |
2015年 | 9254篇 |
2014年 | 12311篇 |
2013年 | 17972篇 |
2012年 | 27398篇 |
2011年 | 29820篇 |
2010年 | 16631篇 |
2009年 | 14269篇 |
2008年 | 25831篇 |
2007年 | 28050篇 |
2006年 | 26962篇 |
2005年 | 26249篇 |
2004年 | 24809篇 |
2003年 | 23766篇 |
2002年 | 22829篇 |
2001年 | 27654篇 |
2000年 | 28606篇 |
1999年 | 23427篇 |
1998年 | 6441篇 |
1997年 | 5241篇 |
1996年 | 5197篇 |
1995年 | 4816篇 |
1992年 | 16412篇 |
1991年 | 17694篇 |
1990年 | 17574篇 |
1989年 | 17041篇 |
1988年 | 15578篇 |
1987年 | 15373篇 |
1986年 | 14333篇 |
1985年 | 13701篇 |
1984年 | 10178篇 |
1983年 | 8655篇 |
1982年 | 4578篇 |
1979年 | 9612篇 |
1978年 | 6837篇 |
1977年 | 5554篇 |
1976年 | 5899篇 |
1975年 | 7110篇 |
1974年 | 7987篇 |
1973年 | 7773篇 |
1972年 | 7114篇 |
1971年 | 6821篇 |
1970年 | 6374篇 |
1969年 | 5978篇 |
1968年 | 5621篇 |
1967年 | 5029篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Jose M. Morales Jose Angel Martinez-Flores Manuel Serrano Maria José Castro Francisco Javier Alfaro Florencio García Miguel Angel Martínez Amado Andrés Esther González Manuel Praga Estela Paz-Artal Antonio Serrano 《Journal of the American Society of Nephrology : JASN》2015,26(3):735-745
In the current immunosuppressive therapy era, vessel thrombosis is the most common cause of early graft loss after renal transplantation. The prevalence of IgA anti–β2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis is elevated (>30%), and these antibodies correlate with mortality and cardiovascular morbidity. To evaluate the effect of IgA-aB2GPI-ab in patients with transplants, we followed all patients transplanted from 2000 to 2002 in the Hospital 12 de Octubre prospectively for 10 years. Presence of IgA-aB2GPI-ab in pretransplant serum was examined retrospectively. Of 269 patients, 89 patients were positive for IgA-aB2GPI-ab (33%; group 1), and the remaining patients were negative (67%; group 2). Graft loss at 6 months post-transplant was significantly higher in group 1 (10 of 89 versus 3 of 180 patients in group 2; P=0.002). The most frequent cause of graft loss was thrombosis of the vessels, which was observed only in group 1 (8 of 10 versus 0 of 3 patients in group 2; P=0.04). Multivariate analysis showed that the presence of IgA-aB2GPI-ab was an independent risk factor for early graft loss (P=0.04) and delayed graft function (P=0.04). There were no significant differences regarding patient survival between the two groups. Graft survival was similar in both groups after 6 months. In conclusion, patients with pretransplant IgA-aB2GPI-ab have a high risk of early graft loss caused by thrombosis and a high risk of delayed graft function. Therefore, pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation. 相似文献
3.
4.
Zaida Araujo Sietze Brandes Elena Pinelli María A. Bochichio Andrea Palacios Albina Wide Bruno Rivas-Santiago Juan Carlos Jiménez 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(1):47-55
The present study aimed at measuring seropositivities for infection by
Ascaris suum and Toxocara canis using the
excretory/secretory (E/S) antigens from Ascaris suum (AES) and
Toxocara canis (TES) within an indigenous population. In
addition, quantification of cytokine expressions in peripheral blood cells was
determined. A total of 50 Warao indigenous were included; of which 43 were adults and
seven children. In adults, 44.1% were seropositive for both parasites; whereas
children had only seropositivity to one or the other helminth. For ascariosis, the
percentage of AES seropositivity in adults and children was high; 23.3% and 57.1%,
respectively. While that for toxocariosis, the percentage of TES seropositivity in
adults and children was low; 9.3% and 14.3%, respectively. The percentage of
seronegativity was comparable for AES and TES antigens in adults (27.9%) and children
(28.6%). When positive sera were analyzed by Western blotting technique using AES
antigens; three bands of 97.2, 193.6 and 200.2 kDas were mostly recognized. When the
TES antigens were used, nine major bands were mostly identified; 47.4, 52.2, 84.9,
98.2, 119.1, 131.3, 175.6, 184.4 and 193.6 kDas. Stool examinations showed that
Blastocystis hominis, Hymenolepis nana and
Entamoeba coli were the most commonly observed intestinal
parasites. Quantification of cytokines IFN-γ, IL-2, IL-6, TGF-β, TNF-α, IL-10 and
IL-4 expressions showed that there was only a significant increased expression of
IL-4 in indigenous with TES seropositivity (p < 0.002).
Ascaris and Toxocara seropositivity was
prevalent among Warao indigenous. 相似文献
5.
6.
7.
Xiaoyan Lu Isabelle R. Miousse Sandra V. Pirela Jodene K. Moore Stepan Melnyk 《Nanotoxicology》2016,10(5):629-639
Evidence continues to grow on potential environmental health hazards associated with engineered nanomaterials (ENMs). While the geno- and cytotoxic effects of ENMs have been investigated, their potential to target the epigenome remains largely unknown. The aim of this study is two-fold: 1) determining whether or not industry relevant ENMs can affect the epigenome in vivo and 2) validating a recently developed in vitro epigenetic screening platform for inhaled ENMs. Laser printer-emitted engineered nanoparticles (PEPs) released from nano-enabled toners during consumer use and copper oxide (CuO) were chosen since these particles induced significant epigenetic changes in a recent in vitro companion study. In this study, the epigenetic alterations in lung tissue, alveolar macrophages and peripheral blood from intratracheally instilled mice were evaluated. The methylation of global DNA and transposable elements (TEs), the expression of the DNA methylation machinery and TEs, in addition to general toxicological effects in the lung were assessed. CuO exhibited higher cell-damaging potential to the lung, while PEPs showed a greater ability to target the epigenome. Alterations in the methylation status of global DNA and TEs, and expression of TEs and DNA machinery in mouse lung were observed after exposure to CuO and PEPs. Additionally, epigenetic changes were detected in the peripheral blood after PEPs exposure. Altogether, CuO and PEPs can induce epigenetic alterations in a mouse experimental model, which in turn confirms that the recently developed in vitro epigenetic platform using macrophage and epithelial cell lines can be successfully utilized in the epigenetic screening of ENMs. 相似文献
8.
9.
Stelter K. Theodoraki M. N. Becker S. Tsekmistrenko V. Olzowy B. Ledderose G. 《European archives of oto-rhino-laryngology》2015,272(3):639-639
European Archives of Oto-Rhino-Laryngology - 相似文献
10.
Rosario Gulias-Cañizo Anell Lagunes-Guillén Arturo González-Robles Erika Sánchez-Guzmán Federico Castro-Muñozledo 《Burns : journal of the International Society for Burn Injuries》2019,45(2):398-412