DEVELOPMENT OF HODGKIN'S DISEASE IN THE COURSE OF PRIMARY SJOGREN'S SYNDROME

We report two patients with a definite diagnosis of primarySjögren's syndrome who developed Hodgkin's disease. Clinicaland laboratory features of this transformation comprised prolongedfever, the appearance of lymphadenopathy together with lossof serum autoantibodies and a reduction in serum gammaglobulinlevels. We know of only one well documented case of such anassociation. From these observations, it seems reasonable toinclude Hodgkin's disease in the clinical spectrum of the lymphoproliferativedisorders that may occur in the course of primary Sjögren'ssyndrome. KEY WORDS: Sjögren's syndrome, Hodgkin's disease, Lymphoma, B-cell