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A. RAMBALDI V. ROSSI P. ALLAVENA M. INTRONA S. LANDOLFO R. BASSAN T. BARBUI A. MANTOVANI 《Scandinavian journal of immunology》1986,23(2):183-188
We have studied five patients with chronic lymphocytosis consisting of large granular lymphocytes (LGL). The increased numbers of LGL in these patients had little or no natural killer activity, mediated antibody-dependent cellular cytotoxicity, and were induced to kill tumour lines after culture for 3 days with interleukin 2 (IL-2). Patients' LGL showed considerable reactivity with HNK-1 and AB8.28 monoclonal antibodies (MoAb), whereas positivity for OKM1 and N901 was found in only two subjects, and only one patient reacted with B73.1. No appreciable reactivity has been found with anti-Tac MoAb in the four patients tested. In the absence of stimulation, the patients' LGL produced no IL-2 and only minimal amounts of IL-1 and interferon (IFN). On stimulation with lipopolysaccharides (for IL-1) or phytohaemagglutinin A (PHA) (for IL-2 and IFN), they produced IL-1 and IFN in amounts similar to those produced by normal lymphocytes, but only modest levels of IL-2. These results indicated that proliferating LGL, like normal LGL, have a secretory capacity. The lack of constitutive lymphokine production, the lack of Tac receptor expression, and the defect in IL-2 production after PHA stimulation do not support the hypothesis of an autocrine proliferation sustained by a known growth factor. 相似文献
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The steroidogenic interrenal cells in the adrenal homologue of the male stickleback ( Gasterosteus aculeatus ) were studied in relation to the reproductive cycle by means of histological and ultrastructural observations, and using histochemical methods for the localisation of 3β-hydroxysteroid dehydrogenase (3βHSD) and 17β-hydroxysteroid dehydrogenase (17βHSD). To determine the various stages of the reproductive cycle, the testes were also examined by histological and histochemical methods (3βHSD). The results indicate that in this teleost the interrenal cells can undergo a cycle in which phases characterised by different cytological aspects are observed. During this cycle there is a renewal of organelles, in particular mitochondria and SER. Periodic degenerative processes are also found. Organelle cytology showed that the cell cycle has at least 3 different aspects during the year. An analogy with some cytological aspects of the adrenal zonation in mammals is possible. It is postulated that the interrenal gland activity could substitute or supplement androgen production by the testes. 相似文献
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Rate‐Control Drugs Affect Variability and Irregularity Measures of RR Intervals in Patients with Permanent Atrial Fibrillation 下载免费PDF全文
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The Effect of ICD Programming on Inappropriate and Appropriate ICD Therapies in Ischemic and Nonischemic Cardiomyopathy: The MADIT‐RIT Trial 下载免费PDF全文
KAMIL SEDLÁČEK M.D. ANNE‐CHRISTINE RUWALD M.D. VALENTINA KUTYIFA M.D. M.Sc. Ph.D. SCOTT MCNITT M.S. POUL ERIK BLOCH THOMSEN M.D. HELMUT KLEIN M.D. MARTIN STOCKBURGER M.D. DAN WICHTERLE M.D. BELA MERKELY M.D. Ph.D. D.Sc. JOAQUIN FERNANDEZ DE LA CONCHA M.D. MOSHE SWISSA M.D. WOJCIECH ZAREBA M.D. Ph.D. ARTHUR J. MOSS M.D. JOSEF KAUTZNER M.D. Ph.D. MARTIN H. RUWALD M.D. Ph.D. for the MADIT‐RIT Investigators 《Journal of cardiovascular electrophysiology》2015,26(4):424-433
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SCORZIELLO MARIA; MANTOVANI ADRIANO; DE MENEGHI DANIELE; DIVERIO SILVANA; MASUNU PETER 《Health promotion international》1993,8(2):103-110
One of the main activities of the Italian Animal Health Programme(IAHP) in the Republic of Zambia, a bilateral project betweenthe Ministry of Agriculture of the Zambian Government and theGeneral Directorate for Development Cooperation of the ItalianMinistry of Foreign Affairs, is the control of Malignant Theileriosisin Southern Province, through immersion of cattle in dip tankscontaining an acaricide. There are potentially important healthrisks to farm workers and the environment as a result of thisintervention and these are discussed. The control measures undertaken,with special reference to health education programmes, are described. 相似文献
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A. RAMBALDI G. ALESSIO V. ROSSI M. B. DONATI N. SEMERARO A. MANTOVANI 《Scandinavian journal of immunology》1985,22(4):363-366
Large granular lymphocytes (LGL) share phenotypic and functional properties with monocytes. We have investigated the production of procoagulant activity (PCA), so far attributed to cells of the monocyte-macrophage lineage, by LGL. Endotoxin triggered interleukin (IL-1) release and PCA activity by highly purified monocyte preparations. In contrast, LGL exposed to endotoxin produced IL-1 but had no PCA activity. Similarly ineffective in inducing PCA in LGL were other stimuli that either triggered monocyte PCA or stimulated the natural killer cytotoxicity of LGL. Thus, although LGL share properties with monocytes such as the capacity to produce IL-1, PCA is confined, among circulating leukocytes, to cells of the monocyte lineage. 相似文献