青少年近视患者配戴渐进多焦眼镜的视光学检查现状初步分析

目的:调查青少年近视患者配戴渐进多焦眼镜的现状,分析其对眼部参数的影响。方法:随机抽查配戴渐进光眼镜的近视患者214名,对其进行视光学检查,包括屈光度、斜视度、AC/A率、辐接近点和融合范围等项目,并调查其心理感受。其检查结果与256名年龄相匹配的戴用单焦眼镜的近视患者相对照,分析其变量的变化。结果:配戴渐变多焦眼镜的近视患者中140例无不适感觉,满意程度明显高于对照组;屈光度平均为-3.5D,约半数患者(48.6％)存在不同程度的外隐斜,其中8位是间歇性外斜患者,没有融合能力,辐辏近点大于20 cm;平均AC/A率为(2.95±1.49),平均融合力为+16.41°～-7.06°,平均辐转近点为(72.63±24.42)mm。实验组除AC/A率低于对照组(t=3.52,P<0.05),且与屈光度无明显相关(r=-0.0318,P>0.05)外,其余检查与对照组之间没有显著性差别。结论:渐进多焦眼镜可以引起AC/A率降低,并有可能通过掩饰间歇性外斜患者 的症状而耽误其治疗。因此,渐进多焦眼镜虽然普遍受青少年近视患者欢迎,但验配中仍存在适应证选择问题,青少年在验配时最好在医生的指导下进行。     

组织型纤溶酶原激活剂及其抑制物的变化与冠心病的关系

目的：观察冠心病患者纤溶活性的变化及其在冠心病发病中的作用，探讨其临床意义。方法：用酶联免疫双抗夹心(ELISA)法测定58例冠心病患者血浆中组织型纤溶酶原激活剂(t—PA)及纤溶酶原激活抑制物-1(PAI-1)抗原含量，反映纤溶-抗纤溶活性的变化，并对冠心病患者组与对照组纤溶指标进行不同性别间的比较。结果：急性心肌梗死、不稳定心绞痛患者PM-1的含量、PAI-1／t—PA比值明显高于对照组，且急性心肌梗死患者PM-1的含量较不稳定心绞痛患者显著为高。但t—PA在急性心肌梗死、不稳定心绞痛患者均无显著降低。患者组及对照组不同性别间纤溶及抗纤溶水平均未见有显著差异。结论：血栓性疾病与纤溶系统的异常有密切关系。纤溶系统活性的变化及纤溶-抗纤溶的平衡失调在缺血性心脏病的发生、发展中起着重要作用。     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

民族医药在肝癌防治中的应用

通过概述土家医、壮医、苗医、蒙医、藏医、侗医、畲医、维吾尔医、傣医等民族医的特色理论和诊疗技法,阐释民族医药在防治肝癌中的应用情况。我国部分少数民族在防治肝癌方面有丰富的用药经验和外治方法,主要通过驱毒、扶正等方法指导肝癌防治,在未病先防、既病防变、改善相关症状等方面发挥着一定的优势。     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.     

反复发热寒颤

1 病历资料 患者男,91岁.因"反复发热伴寒颤3年余,再发1 d"于2008年11月来我院国际医疗部急诊.     

长春新碱通过下调SODD蛋白表达诱导白血病细胞凋亡新机制研究

 目的研究死亡结构域沉默子(silencer of death domains,SODD)、caspase3、caspase8及caspase9在长春新碱诱导Jurkat白血病细胞凋亡过程中的变化,探讨长春新碱诱导肿瘤细胞凋亡的新机制。方法采用Annexin V/PI双标记流式细胞术检测长春新碱(VCR)作用后Jurkat细胞凋亡发生率;采用免疫印迹法分析SODD、caspase3、caspase8及caspase9蛋白表达的变化;ELISA酶联免疫吸附技术检测VCR作用Jurkat细胞后TNF-α分泌的变化;采用RT-PCR检测VCR对细胞,TNFR1mRNA表达的调节。结果Jurkat白血病细胞SODD蛋白高表达且高表达的SODD蛋白抑制肿瘤细胞凋亡,VCR能特异下调SODD蛋白的表达,有效诱导Jurkat细胞凋亡,但并不影响细胞TNF-α的分泌及TNFR1的表达;VCR诱导细胞凋亡过程中caspase3、caspase8酶原呈时间依赖性逐渐被水解剪切,而caspase9在该凋亡过程中无明显变化趋势。结论VCR下调SODD蛋白表达并启动外源性凋亡途径caspases级联(caspase8、caspase3),最终诱导Jurkat细胞凋亡,且VCR下调SODD蛋白的表达无需激活TNF/TNFR1信号途径即可导致凋亡的发生。     

用于乳腺检测的多通道扩散光学层析成像系统

基于光子计数原理，研发了一套用于乳腺检测的多通道连续光（CW）扩散光学层析成像（DOT）系统。系统采用了“无间歇可调宽度滑动门计数器”以动态记录信息。每个滑动门宽可以从50μs变化到十几秒，相应地，根据预设门的数目，总测量时间跨度为几毫秒至几十秒。数据传输压系统控制应用通用串行总线（USB）2．0接口，增强了系统的可扩展性，可以满足不同空间分辨率的需要。     

冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响

Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.