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排序方式: 共有479条查询结果,搜索用时 31 毫秒
1.
Ibrahim Ercan Burak Omür Cakir Tulin Sentürk Uzel Damlanur Sakiz Cetin Karaca Suat Turgut 《Otolaryngology--head and neck surgery》2006,135(1):52-55
OBJECTIVES: To investigate the role of Helicobacter pylori (H pylori) infection in laryngopharyngeal reflux (LPR). STUDY DESIGN: A prospective multidisciplinary clinical study. METHODS: Forty-four adult patients who applied to our ENT clinic with LPR symptoms were evaluated. Then these patients underwent upper gastrointestinal system endoscopy and double probe pH monitoring. In addition, during the endoscopy multiple biopsies from the stomach were obtained to detect H pylori. RESULTS: Results from 32 LPR positive patients were assessed (10 male and 22 female). There were no statistically significant differences between the presence of H pylori and sex, age, degree of gastritis and esophagitis, and also the number of reflux, fractional acid exposure time regarding proximal probe readings. Similarly for both proximal and distal probe readings, the average score of esophageal acid clearance was not statistically significant (P > 0.05). In addition, no statistically significant difference was found between the presence of H pylori and GERD (P > 0.05). CONCLUSIONS: The results of this study demonstrated that there is no relationship between gastric H pylori infection and LPR. EBM rating: B-3b. 相似文献
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The effect of anticoagulation on antenatal ultrasound findings in pregnant women with thrombophilia.
Urania Magriples Tulin Ozcan Anita Karne Joshua Abbott Copel 《The journal of maternal-fetal & neonatal medicine》2006,19(1):27-30
OBJECTIVE: To assess whether treatment with heparin alters ultrasound findings in pregnant women with inherited thrombophilia. METHODS: This was a retrospective study of a cohort of patients referred for pregnancy complications who were found to have genetic thrombophilia. Ultrasounds were reviewed in treated and untreated pregnancies for the presence of growth restriction, oligohydramnios or abnormal Doppler results. RESULTS: There were a total of 178 pregnancies in 51 patients. The overall percentage of abnormal ultrasounds was significantly greater in the untreated compared with treated pregnancies (52.8% vs. 27.9%; p = 0.024.) Growth restriction and abnormal Doppler results were more common in untreated pregnancies. There was a significantly decreased risk of oligohydramnios with treatment (27.3% vs. 7%; p = 0.03). Overall outcomes were significantly improved with the use of anticoagulation ( p < 0.0001). CONCLUSIONS: Treatment markedly improves ultrasound parameters of growth, fluid and feto-placental blood flow in patients with thrombophilia. The presence of abnormalities despite treatment reinforces the need for close antenatal surveillance. 相似文献
4.
毒性中药饮片的安全性、有效性与质量可控性是中医药传承与创新的核心,而炮制工艺的科学合理是保证毒性中药饮片应用安全有效的关键。本文概述了毒性中药饮片发展过程及质量控制现状,并对其存在的问题进行分析总结。毒性中药主要通过加工炮制达到减毒增效的目的以保障临床安全有效,因此针对毒性中药饮片炮制现状进行综述,系统梳理了古今毒性中药饮片炮制工艺,初步阐述了毒性中药饮片炮制减毒机制。在此基础之上,针对毒性中药饮片炮制研究,提出基于中医药整体观系统开展炮制过程动态变化规律研究,基于中医药和谐观解析炮制过程中物质相互作用科学内涵,为明晰毒性中药饮片炮制机制,规范毒性中药饮片炮制工艺,实现毒性中药饮片质量控制,保障毒性中药饮片临床安全有效提供参考借鉴。 相似文献
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Journal of Thrombosis and Thrombolysis - Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis. Congenital plasminogen... 相似文献
7.
The effect of inhaled corticosteroids on bronchoalveolar lavage cells and IL-8 levels in stable COPD patients 总被引:2,自引:0,他引:2
Chronic obstructive pulmonary disease (COPD) is characterised by a chronic inflammatory process in the large and small airways, as well as in the lung parenchyma. Although the role of oral corticosteroids in the management of acute exacerbations of COPD is well documented, its role in stable COPD is not clear. We examined the anti-inflammatory effect of inhaled budesonide on the percentage of neutrophils and on interleukin-8 (IL-8) levels in bronchoalveolar lavage (BAL) and their correlation with spirometry and symptom scores. Twenty-six patients with stable COPD were randomised, in a double-blinded, placebo-controlled trial with either 800 microg of inhaled budesonide or placebo for a 6-month period. The budesonide-treated subjects had significant reductions in IL-8 levels in the BAL after therapy (mean+/-sem, 1.53+/-0.72 at baseline vs. 0.70+/-0.48 ng/ml at 6 months, P=0.004) and a reduction in the mean percentages of neutrophils (17.16+/-2.67% vs. 13.25+/-2.28% P=0.002). The improvement in sputum production was of borderline (P=0.058) significance but there was no improvement in lung function. In stable patients with COPD, treatment with inhaled budesonide for a period of 6 months has a positive effect on markers of lung inflammation, as assessed by reduction in percentage neutrophils and IL-8 concentration in BAL. 相似文献
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Zeynep Tuna Tulin Duger Nevin Atalay-Guzel Arzu Aral Bilkay Basturk Seminur Haznedaroglu Berna Goker 《Journal of Physical Therapy Science》2015,27(4):1239-1242
[Purpose] Although oxidative stress is known to be present in rheumatoid arthritis (RA),
the effects of exercise on oxidative parameters are unknown. The aim of this study was to
investigate the effects of acute aerobic exercise on serum oxidant and antioxidant levels
in patients with RA. [Subjects and Methods] Sixteen patients with RA and 10 age-matched
healthy volunteers participated in this study. All participants wore polar telemeters and
walked on a treadmill for 30 minutes at a speed eliciting 60–75% of maximal heart rates.
Blood samples were obtained before, immediately and 24 hours after exercise and
malondialdehyde (MDA) and total sulfhydrile group (RSH) levels were measured. [Results]
Both groups had similar heart rates during the test but the treadmill speed of the RA
patients was significantly lower than that of the healthy volunteers. Serum MDA levels
were lower than in both groups immediately after exercise, with greater decrements in the
RA patients than controls. MDA levels returned to baseline 24 hours after the exercise
only in the controls; they remained low in the RA patients. There was a slight increase in
serum RSH levels after exercise compared to baseline in both groups. [Conclusion] Moderate
intensity treadmill exercise did not have any adverse effect on the oxidant-antioxidant
balance. The results suggest that such an exercise may be safely added to the
rehabilitation program of RA for additional antioxidant effects. Morever, this antioxidant
environment is maintained longer in RA patients.Key words: Aerobic exercise, Oxidative status, Rheumatoid arthritis 相似文献
10.
Does patient education increase antimuscarinic treatment persistence in overactive bladder syndrome? 下载免费PDF全文
Tulin Yildiz RN PhD Cenk M Yazici MD Cagri Dogan MD Muzeyyen Cetintas RN Arzu Malak RN 《International Journal of Urological Nursing》2015,9(2):84-91
Overactive bladder syndrome (OAB) is a chronic condition that requires long‐term management. Patient education may have role in decreasing the unfavourable effects of long‐term treatment of OAB. The aim of the study was to evaluate the effect of detailed patient education on the patients' persistence with antimuscarinic treatment for OAB. A total of 140 patients with the diagnosis of OAB were included in this study. Patients were randomly divided into two groups. Patients in Group 1 were given information by the same urology doctor about the disease and treatment. Patients in Group 2 were given information by a urology nurse. Patients were recalled in the first, third and sixth months of treatment. The treatment persistency was evaluated in the whole study population and between the groups. The persistency rates of the whole group were 88·6% in the first month, 65·7% in the third month and 45·7% in the sixth month. At the end of the sixth month, 42·8% of males and 47·1% of females were taking antimuscarinics (p = 0·580). The persistence rate of Groups 1 and 2 were 82·8 and 94·3% at the first month. (p = 0·034). It decreased to 31·4% in the first and 60% in the second group at the sixth month (p = 0·001). The persistence rate of antimuscarinic treatment is low. Patient education is simple and effective way of increasing persistence. Clinicians must pay attention to inform their patients about the disease and possible side effects of treatment. An educated health provider may be very helpful in educating patients for OAB. 相似文献