全文获取类型
收费全文 | 3833篇 |
免费 | 230篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 45篇 |
妇产科学 | 38篇 |
基础医学 | 600篇 |
口腔科学 | 171篇 |
临床医学 | 324篇 |
内科学 | 926篇 |
皮肤病学 | 104篇 |
神经病学 | 262篇 |
特种医学 | 168篇 |
外科学 | 568篇 |
综合类 | 17篇 |
预防医学 | 185篇 |
眼科学 | 42篇 |
药学 | 263篇 |
中国医学 | 5篇 |
肿瘤学 | 322篇 |
出版年
2023年 | 23篇 |
2022年 | 59篇 |
2021年 | 79篇 |
2020年 | 68篇 |
2019年 | 77篇 |
2018年 | 82篇 |
2017年 | 63篇 |
2016年 | 80篇 |
2015年 | 98篇 |
2014年 | 123篇 |
2013年 | 173篇 |
2012年 | 281篇 |
2011年 | 300篇 |
2010年 | 185篇 |
2009年 | 169篇 |
2008年 | 247篇 |
2007年 | 259篇 |
2006年 | 266篇 |
2005年 | 244篇 |
2004年 | 210篇 |
2003年 | 217篇 |
2002年 | 175篇 |
2001年 | 42篇 |
2000年 | 19篇 |
1999年 | 39篇 |
1998年 | 42篇 |
1997年 | 34篇 |
1996年 | 37篇 |
1995年 | 29篇 |
1994年 | 16篇 |
1993年 | 23篇 |
1992年 | 34篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 12篇 |
1988年 | 12篇 |
1987年 | 17篇 |
1986年 | 17篇 |
1985年 | 18篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 9篇 |
1981年 | 9篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1971年 | 7篇 |
1964年 | 8篇 |
1955年 | 7篇 |
排序方式: 共有4084条查询结果,搜索用时 15 毫秒
1.
2.
3.
Torsten T. Bauer Joachim Lorenz Klaus-Friedrich Bodmann Friedrich Vogel 《Medizinische Klinik》2005,26(13):355-360
Hintergrund:
Die nosokomiale Pneumonie gehört zu den häufigsten nosokomialen Infektionen und ist die häufigste auf der Intensivstation. Die nosokomiale Pneumonie ist mit einer signifikanten Mortalität und Morbidität assoziiert, und ihr Auftreten verschlechtert die Prognose des Patienten deutlich. Nach der Definition der DRGs auch im deutschen Krankenhaussystem ist die nosokomiale Pneumonie überwiegend Sache des Krankenhauses und kann somit nicht nur das Ergebnis der Patientenbehandlung, sondern auch das finanzielle Ergebnis des Krankenhauses beeinträchtigen. 相似文献4.
Dimmeler Stefanie; Tonn Torsten; Seeger Florian; Zeiher Andreas M. 《European heart journal》2007,28(17):2175
It obviously escaped the notion of Egeland and Brinchman thatthe protocols additionally differ with regard to the washingsteps and buffer components used in the 相似文献
5.
Glutathione S-transferases in human testicular germ cell tumors: changes of expression and activity.
Glutathione S-transferases are involved in the detoxification of carcinogens and xenobiotics and are potentially associated with the development of drug-resistance. Forty-six testicular germ cell tumors and 33 adjacent normal testicular tissue specimens were analyzed at the RNA level for the expression of glutathione S-transferase alpha and pi. Glutathione S-transferase alpha was expressed in 31 of the 33 normal testicular tissues (94%) but in only three of the 46 germ cell tumors (7%). Glutathione S-transferase pi mRNA was detected in all normal and malignant testicular tissue samples. Thirteen testicular germ cell tumors and eight normal testicular tissue samples were analyzed at the protein level. The mean specific activity of total cytosolic glutathione S-transferase in tumor tissue was decreased by about 80% as compared to normal testicular tissue. Protein analysis of the glutathione S-transferase subunits of normal testicular tissue demonstrated the presence of the glutathione S-transferase classes alpha, mu and pi, with a predominance of the mu class. In testicular germ cell tumors the glutathione S-transferase subunit pattern showed a predominance of glutathione S-transferase pi representing 88% +/- 3% of total glutathione S-transferase. Since all three glutathione S-transferase isoenzyme classes contribute to the resistance to antineoplastic drugs, the altered glutathione S-transferase isoenzyme pattern and the decrease of glutathione S-transferase activity may play a role in the high inherent drug sensitivity of human testicular germ cell tumors. 相似文献
6.
Effects of Helicobacter pylori on histamine and carbachol stimulated acid secretion by human parietal cells. 总被引:2,自引:1,他引:1
下载免费PDF全文
![点击此处可从《Gut》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Helicobacter pylori (H pylori) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiological pathways by which H pylori interacts with acid secretion are still unclear. The effects of H pylori on (14C) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. Isolated oxyntic glands were stimulated with submaximal concentrations of histamine or carbachol and incubated with sonicates of different H pylori strains. Omeprazole and sonicates of Campylobacter jejuni served as positive and negative controls, respectively. Two of four H pylori strains reduced hydrochloric acid sequestration within the parietal cells significantly and in a dose dependent manner in up to 80%. Interaction with acid secretion may therefore constitute a factor contributing to a distinct pathogenicity of H pylori strains. 相似文献
7.
Hans Rommelspacher Lutz G. Schmidt Torsten May 《Alcoholism, clinical and experimental research》1991,15(3):553-559
Based on the hypothesis that condensation products of neurotransmitters with aldehydes are involved in the pathogenesis of alcoholism, aromatic beta-carbolines (norharman and harman) were measured in the blood plasma of alcoholics and nonalcoholics. The identity of the extracted compounds was confirmed by various elution conditions of the high performance liquid chromatography (HPLC), newly developed radioreceptor assays, and the mass spectrum of norharman. The levels of norharman and harman in nonalcoholics were unchanged after a load with ethanol (1 g/kg body weight). The norharman levels of the alcoholics were significantly higher than that of the nonalcoholic controls (99.5 +/- 26.6 pg/ml vs. 26.9 +/- 10.7 pg/ml; p less than 0.001) and did not change significantly during a 3-week detoxication period. In the subgroup of alcoholics with delirium or hallucinosis, a slight increase of norharman during detoxication could be detected while in alcoholics with vegetative withdrawal symptoms norharman levels dropped slightly over time (p = 0.07). No difference was found with respect to harman between nonalcoholics and alcoholics. These results suggest disturbed regulatory processes in the formation and/or metabolism of norharman in alcoholics. Further investigations are needed to reveal a possible marker function of norharman in alcoholic patients. 相似文献
8.
9.
10.
Jürgen Vogt Torsten Schwarz Daniel Gras Johannes Sperzel Philippe Ritter Willem de Voogt Jean-Pierre Cebron Martin Seifert Bruce Tockman Bernd Schubert Eric Johnson Annette Doelger Thierry Pochet Elisabeth Mouton Christian Butter 《Journal of interventional cardiac electrophysiology》2007,19(1):61-68
Introduction Failure to enter the coronary sinus (CS) with a guiding catheter and entering its tributaries remains challenging in left
ventricle (LV) pacing lead implants for cardiac resynchronization therapy (CRT). A dual telescoping catheter system (8F outer/6F
inner) is designed to provide the ability to adjust the catheter curve size, shape and/or reach to the patients’ anatomy avoiding
the need for catheter change.
Methods Five different designs for CS cannulation were randomly tested in 64 patients scheduled for CRT device implant.
Results In 33 consecutive patients three adaptable telescoping guiding catheter systems were tested per patient, the adaptable catheters
had higher overall cannulation success rates (68, 63 and 62%) compared to the fixed shape catheter (46%) and an greater cannulation
success rate when the CS location was not known (70, 53 and 72% vs 33% for the fixed shape). In a second group of 31 CRT patients
the two telescoping catheters had similar high levels of success (71–80%), with or without using the inner catheter.
Conclusions The telescopic system is adaptable to a wide range of anatomical variations in patients and can result in a higher CS cannulation
success rate due to its adjustability in the RA in search for the CS ostium. On top of this the inner catheter allows for
sub-selecting the CS tributaries. 相似文献