全文获取类型
收费全文 | 1973篇 |
免费 | 75篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 50篇 |
妇产科学 | 63篇 |
基础医学 | 205篇 |
口腔科学 | 133篇 |
临床医学 | 224篇 |
内科学 | 297篇 |
皮肤病学 | 39篇 |
神经病学 | 163篇 |
特种医学 | 275篇 |
外科学 | 96篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 88篇 |
眼科学 | 33篇 |
药学 | 244篇 |
中国医学 | 3篇 |
肿瘤学 | 165篇 |
出版年
2023年 | 9篇 |
2022年 | 7篇 |
2021年 | 11篇 |
2020年 | 11篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 16篇 |
2016年 | 20篇 |
2015年 | 26篇 |
2014年 | 31篇 |
2013年 | 41篇 |
2012年 | 59篇 |
2011年 | 61篇 |
2010年 | 56篇 |
2009年 | 80篇 |
2008年 | 77篇 |
2007年 | 110篇 |
2006年 | 82篇 |
2005年 | 68篇 |
2004年 | 62篇 |
2003年 | 62篇 |
2002年 | 56篇 |
2001年 | 68篇 |
2000年 | 73篇 |
1999年 | 55篇 |
1998年 | 96篇 |
1997年 | 83篇 |
1996年 | 83篇 |
1995年 | 66篇 |
1994年 | 58篇 |
1993年 | 54篇 |
1992年 | 39篇 |
1991年 | 35篇 |
1990年 | 55篇 |
1989年 | 60篇 |
1988年 | 43篇 |
1987年 | 41篇 |
1986年 | 35篇 |
1985年 | 28篇 |
1984年 | 25篇 |
1983年 | 14篇 |
1982年 | 21篇 |
1981年 | 11篇 |
1980年 | 13篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 17篇 |
1976年 | 13篇 |
1975年 | 13篇 |
1972年 | 5篇 |
排序方式: 共有2123条查询结果,搜索用时 15 毫秒
1.
P Avalos-Peralta† A Herrera† JJ Ríos-Martín‡ AM Pérez-Bernal† D Moreno-Ramírez† F Camacho† 《Journal of the European Academy of Dermatology and Venereology》2006,20(1):79-83
We report the case of a patient with a 13-year history of pemphigus vulgaris (PV) treated with immunosuppressive agents, prednisone and mycophenolate mofetil who had developed lesions of Kaposi's sarcoma (KS) on a sole plaque of PV that had been previously treated with intralesional injections of steroids. The lesions were surgically removed and polymerase chain reaction (PCR) demonstrated human herpesvirus-8 (HHV-8) DNA. There were neither recurrences nor later dissemination of KS following gradual decrease of the immunosuppressive therapy. We suggest that the treatment with intralesional steroids may have influenced the local reactivation of a latent infection of the virus, determining the appearance of this localized KS. 相似文献
2.
The potential antipsychotic activity of the partial dopamine receptor agonist (+)N-0437 总被引:1,自引:0,他引:1
The (+) enantiomer of the very potent and selective dopamine D-2 agonist, 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0437), displays partial agonistic activity at dopamine D-2 receptors. In this study (+)N-0437 was investigated for its antagonistic activity at postsynaptic DA receptors in four behavioural tests which are commonly used to evaluate potential neuroleptic activity, i.e. d-amphetamine-induced stereotypy, passive avoidance responding, intracranial self-stimulation behaviour, and catalepsy. (+)N-0437 (25-50 mumol/kg) was active in the first three models, but did not cause catalepsy. Haloperidol, which was used as a reference compound for classical DA antagonists, showed clear activity in all four models at low doses (0.5-1.0 mumol/kg). (-)N-0437, a full D-2 agonist, displayed no activity in these behavioural models. These results suggest that (+)N-0437 could be used to examine the hypothesis that the use of partial agonists could provide a new treatment for schizophrenia. 相似文献
3.
CM Reid M. Nelson P. Beckinsale P. Ryan LMH Wing LJ Beilin MA Brown GLR Jennings CI Johnston J. Marley JJ McNeil TO Morgan J. Shaw ID Steven MJ West 《Clinical and experimental pharmacology & physiology》1997,24(5):370-373
1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 160 mmHg systolic or 90 mmHg diastolic if systolic BP was 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial. 相似文献
4.
5.
6.
SUMMARY A young patient presenting with splenomegaly and hypersplenism was inadvertently found to have selective IgA deficiency. There were no symptoms of immunodeficiency and the patient responded well to splenectomy, with return of blood counts to normal without adverse effects. No other cause for the hypersplenism was found. We postulate selective IgA deficiency as a cause of splenomegaly and hypersplenism. 相似文献
7.
Vigo T Schenone A Mancardi G Abruzzese M Timmerman V Van Hummelen P Nobbio L . 《Journal of the peripheral nervous system : JPNS》2004,9(2):111-111
CMT1A patients bear the same genetic defect but often present with a wide range of clinical disability. Knowing the relationship between the phenotypic variability and other parameters, such as electrophysiological findings, age, gender, disease duration and environmental factors may be important for understanding the pathogenetic mechanisms underlying CMT1A. We studied 15 families and 7 sporadic cases affected by CMT1A (27 adults and 9 children) from the clinical, neurophysiological and genetic standpoint. A detailed patient history included: disease onset and progression, distribution of weakness, additional symptoms, life habits, genealogical tree, exposure to toxic substances, geographic provenance, instruction grade, job, use of drugs, and concurrent diseases. A questionnaire about diet was administered. The disability was evaluated by modified Rankin scale, deambulation index, functional independence measure and Barthel index. As previously reported, disease onset was in the first decade in 50% of cases and before the age of 20 years in 70% of cases. Severe disability was rarely observed, only 2 patients walking with a cane. No clear influence of gender over clinical severity was observed. Interestingly, genetic anticipation was observed in all the families. Data on the influence of environmental factors will also be presented. 相似文献
8.
A mobility protocol for critically ill adults. 总被引:1,自引:0,他引:1
Rosemary A Timmerman 《Dimensions of critical care nursing》2007,26(5):175-9; quiz 180-1
Although the complications of immobility are well-described in the literature, critically ill patients are often subjected to prolonged periods of bed rest. Nurses, by virtue of their expertise in preventing iatrogenic complications, are in an ideal position to prevent the adverse outcomes associated with immobility. This article describes how nurses can use a mobility protocol to increase the activity of critically ill patients in a timely manner that may prevent the infirmity and suffering that is caused by unnecessarily long periods of bed rest. 相似文献
9.
The displaced femoral neck fracture. Internal fixation versus bipolar endoprosthesis. Results of a prospective, randomized comparison 总被引:3,自引:0,他引:3
T J Bray E Smith-Hoefer A Hooper L Timmerman 《Clinical orthopaedics and related research》1988,(230):127-140
The displaced femoral neck fracture poses difficult decision-making issues for the orthopedic surgeon. Young patients frequently require a rapid open reduction and rigid internal fixation in the face of multiple associated injuries. Elderly patients present the typical decision dilemma of internal fixation versus arthroplasty. Consecutive, randomized, prospective series of cases for evaluation of alternatives in the treatment of this difficult fracture are lacking. Between 1982 and 1984, 34 elderly patients with displaced femoral neck fractures were randomized to open reduction or hemiarthroplasty study groups. Although the surgical risks are relatively high, two-year observations showed better functional results in the cemented hemiarthroplasty group. 相似文献
10.