全文获取类型
收费全文 | 850篇 |
免费 | 48篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 44篇 |
妇产科学 | 149篇 |
基础医学 | 83篇 |
口腔科学 | 12篇 |
临床医学 | 84篇 |
内科学 | 115篇 |
皮肤病学 | 6篇 |
神经病学 | 41篇 |
特种医学 | 149篇 |
外科学 | 53篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 71篇 |
眼科学 | 2篇 |
药学 | 36篇 |
1篇 | |
肿瘤学 | 19篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 9篇 |
2020年 | 11篇 |
2019年 | 14篇 |
2018年 | 5篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 10篇 |
2014年 | 7篇 |
2013年 | 22篇 |
2012年 | 38篇 |
2011年 | 37篇 |
2010年 | 22篇 |
2009年 | 19篇 |
2008年 | 31篇 |
2007年 | 37篇 |
2006年 | 36篇 |
2005年 | 29篇 |
2004年 | 23篇 |
2003年 | 17篇 |
2002年 | 15篇 |
2001年 | 22篇 |
2000年 | 12篇 |
1999年 | 35篇 |
1998年 | 26篇 |
1997年 | 17篇 |
1996年 | 34篇 |
1995年 | 21篇 |
1994年 | 27篇 |
1993年 | 20篇 |
1992年 | 18篇 |
1991年 | 22篇 |
1990年 | 24篇 |
1989年 | 31篇 |
1988年 | 22篇 |
1987年 | 28篇 |
1986年 | 17篇 |
1985年 | 14篇 |
1984年 | 10篇 |
1983年 | 12篇 |
1982年 | 13篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1977年 | 9篇 |
1976年 | 12篇 |
1959年 | 3篇 |
1946年 | 2篇 |
排序方式: 共有908条查询结果,搜索用时 78 毫秒
1.
Prevalence, morbidity and service need among South Asian and white adults with intellectual disability in Leicestershire, UK 总被引:1,自引:0,他引:1
C. W. McGrother S. Bhaumik C. F. Thorp J. M. Watson & N. A. Taub 《Journal of intellectual disability research : JIDR》2002,46(4):299-309
Background Previous reports have suggested that South Asian and white UK populations have different prevalences of intellectual disability (ID), related psychological morbidity and service use. The aim of the present study was to compare these rates among South Asian and white adults in Leicestershire, UK. Method This cross‐sectional study is comprised of two parts. The analysis of prevalence is based on data from all South Asian and white adults known to the Leicestershire Learning Disabilities Register in 1991, with population denominators being drawn from the 1991 census. The other analyses use data collected from the most recent semi‐structured home interviews, carried out between 1987 and 1998, with 206 South Asian and 2334 white adults. Results The prevalence of ID in adults in Leicestershire is 3.20 per 1000 in South Asians and 3.62 per 1000 in whites. Among adults with ID, South Asians have similar prevalences of disabilities to whites and significantly lower skill levels. South Asians show similar levels of psychological morbidity, but make significantly lower use than whites of psychiatric services, residential care and respite care. South Asians use community services as extensively as whites, but feel that they have a substantially greater unmet need, especially with regard to social services. Conclusion South Asian and white populations have similar prevalences of ID and related psychological morbidity. Culturally appropriate services for South Asian adults may need to focus on skill development and community care. 相似文献
2.
Physical aggression towards others in adults with learning disabilities: prevalence and associated factors 总被引:1,自引:0,他引:1
F. Tyrer C. W. McGrother C. F. Thorp M. Donaldson S. Bhaumik J. M. Watson & C. Hollin 《Journal of intellectual disability research : JIDR》2006,50(4):295-304
Background Many people with learning disabilities (LD) show aggressive behaviour, but the extent of the problem and its associated factors and effects are unclear. Methods A cross‐sectional analysis was carried out using interview data from 3065 adults with LD on the Leicestershire LD Register. Physical aggression towards others was defined as carers reporting frequent (more than three times per week) and/or severe episodes. Individuals with and without aggression were compared using multiple logistic regression models for potential physical and psychological factors. Results Carers reported that 443 (14%) of adults were physically aggressive towards others. Men (P = 0.001), younger individuals (P < 0.001), people with more severe LD (P < 0.001) and those in institutional settings (P < 0.001) had a significantly higher prevalence of physical aggression. People with Down syndrome had a lower prevalence of physical aggression (P < 0.001). After adjustment, we found no relationship between aggression and the presence of epilepsy or autism. Among psychological factors, symptoms of frustration (P < 0.001) and mood swings (P < 0.001) were associated with higher levels of aggression. Failure to cope among carers was reported by 14% overall: 42% of people caring for adults with aggression said they were unable to cope compared with 10% of those caring for adults without aggression. Conclusions Physical aggression towards other people presents a significant challenge to carers of adults with LD. Further research is needed to identify aetiological factors with a view to finding effective interventions to reduce, and improve management of, this behaviour. 相似文献
3.
J A Thorp G R Cohen J D Yeast D Perryman C Welsh N Honssinger S Stephenson J Hedrick 《American journal of perinatology》1992,9(1):22-24
Fetal hydrops at 26 weeks' gestation was diagnosed following a massive fetomaternal hemorrhage. Fetal intravascular transfusion was performed, and the hydrops completely resolved within 72 hours. The fetus required one more transfusion at 27 weeks' gestation. A subsequent percutaneous umbilical blood sampling at 30 weeks' gestation demonstrated a normal fetal hematocrit. A vaginal delivery at term resulted in a normal newborn. Massive fetomaternal hemorrhage is a well-known cause of nonimmune hydrops and may occur spontaneously in an otherwise normal pregnancy. Confirmation by percutaneous umbilical blood sampling and treatment by intravascular transfusion is recommended when massive fetomaternal hemorrhage causes hydrops in preterm gestations. 相似文献
4.
5.
Submucous myomas treated with gonadotropin releasing hormone agonist and resulting in vaginal hemorrhage. A case report 总被引:1,自引:0,他引:1
Gonadotropin releasing hormone agonists are often used in the management of myomas in an attempt to decrease both the myoma and uterine volume. This therapy in a woman with submucous myomas resulted in profuse vaginal bleeding requiring a transfusion and myomectomy. 相似文献
6.
进一步研究了抗三尖杉酯碱的HL-60细胞(HR20)抗细胞凋亡的机制及该抗性和抗药性的关系。结果表明,环孢菌素A(CsA)20,10μg·ml ̄(-1)诱导HL-60细胞发生凋亡,而阻断HR20细胞于G_1期,就不能诱导细胞发生凋亡。低浓度的CsA明显增加柔红霉素在HR20细胞内的积聚,其逆转抗药性作用与阻断细胞周期运行无关。CsA10μg·ml ̄(-1)处理HR20细胞,可引起50kDa的蛋白质高度磷酸化。结果提示:环孢菌素A阻断抗三尖杉酯碱的HL-60细胞于G_1期,而诱导敏感的HL-60细胞发生凋亡,其阻断作用与抗药性无关 相似文献
7.
Hydrolysis of peptides within lumen of small intestine 总被引:2,自引:0,他引:2
8.
Summary The relationships of VII and VIII cranial nerves and related arteries are reviewed in 26 preparations by microdissection techniques. These vessels may be grouped in large (AICA, PICA), medium (LA, SA, CSA, RPI) and small calibre (vasa nervorum, radicullar and medullar branches). The importance of these structures in acoustic neuroma surgery, vestibular neurectomy and cross-compression syndromes is discussed. Vascular loops and elongated arteries are normal structures present at birth.This work was supported by a grant from the AJ Roemmers Foundation 相似文献
9.
Differential pattern of DNA-aneuploidy in human malignancies 总被引:5,自引:0,他引:5
Th Büchner W Hiddemann B Wörmann B Kleinemeier J Schumann W Göhde J Ritter K.-M Müller DB von Bassewitz A Roessner E Grundmann 《Pathology, research and practice》1985,179(3):310-317
The differential pattern of DNA-aneuploidy, detected by flow cytometry (FCM) regarding its frequency, grade and multiclonality, was investigated and correlated to tumor type, malignancy grade, tumor stage and prognosis in a multi-institutional study at the University of Münster. High resolution measurements using admixed normal blood reference cells were undertaken in 2413 cases of 13 different malignant diseases and in 776 benign lesions or samples. The incidence of DNA-aneuploidy was highest in melanomas, carcinomas, testicular tumors, sarcomas (75%-95%) and myelomas (65%). Acute leukemias showed an intermediate DNA-aneuploidy rate of 40% with special subgroups represented by common ALL (44%), p less than 0.05) and myelomonocytic/monocytic AML (47%, p less than 0.01). The lowest DNA-aneuploidy-rate was found in basal cell skin carcinomas (19%) and congenital melanocytic nevi (9%). No case of DNA-aneuploidy was observed in the 776 benign lesions or samples.--DNA-indices giving the grade of DNA-aneuploidy with 1.0 for normal diploid G1/0 cells were found distributed predominantly between 1.0 and 2.0 in the solid tumors, except testicular tumors, clustering around a triploid maximum at 1.5. DNA-indices of myelomas and acute leukemias generally ranged below 1.25 with lower DNA-aneuploidy grades in AML than in ALL (p less than 0.01).--In melanomas the aneuploidy rate was higher (86%) in metastases than in the primary tumors (54%, p = 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献