全文获取类型
收费全文 | 2066篇 |
免费 | 179篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 50篇 |
妇产科学 | 28篇 |
基础医学 | 258篇 |
口腔科学 | 60篇 |
临床医学 | 226篇 |
内科学 | 486篇 |
皮肤病学 | 41篇 |
神经病学 | 127篇 |
特种医学 | 56篇 |
外国民族医学 | 3篇 |
外科学 | 318篇 |
综合类 | 18篇 |
现状与发展 | 1篇 |
一般理论 | 9篇 |
预防医学 | 180篇 |
眼科学 | 90篇 |
药学 | 143篇 |
中国医学 | 11篇 |
肿瘤学 | 140篇 |
出版年
2024年 | 2篇 |
2023年 | 21篇 |
2022年 | 62篇 |
2021年 | 161篇 |
2020年 | 78篇 |
2019年 | 78篇 |
2018年 | 97篇 |
2017年 | 72篇 |
2016年 | 49篇 |
2015年 | 65篇 |
2014年 | 81篇 |
2013年 | 108篇 |
2012年 | 145篇 |
2011年 | 153篇 |
2010年 | 69篇 |
2009年 | 89篇 |
2008年 | 101篇 |
2007年 | 132篇 |
2006年 | 103篇 |
2005年 | 102篇 |
2004年 | 99篇 |
2003年 | 66篇 |
2002年 | 80篇 |
2001年 | 50篇 |
2000年 | 36篇 |
1999年 | 29篇 |
1998年 | 16篇 |
1997年 | 12篇 |
1996年 | 5篇 |
1995年 | 8篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 10篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 9篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1971年 | 2篇 |
排序方式: 共有2250条查询结果,搜索用时 31 毫秒
1.
Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers
下载免费PDF全文
![点击此处可从《Asian Pacific journal of cancer prevention》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Thao Phuong Bui Phuong Lan LeLinh Thi Tu Nguyen Le Trung ThoThai Hong Trinh 《Asian Pacific journal of cancer prevention》2022,23(6):1893-1900
Background: Considering the poor prognosis of non-small cell lung cancer (NSCLC), the objective of this study was to examine the potential of plasma-derived vesicles as a source of lung cancer-specific proteins. Extracellular vesicle (EV) cargos are specific to the source cells, hence they have the potential of being a source of cancer-specific proteins. Methods: The proteins differently expressed in cancer were determined and derived from EVs isolated from the plasma of NSCLC patients at the National Lung Hospital. To this end, purification was done using gel filtration chromatography and ultracentrifugation. In addition, nano liquid chromatography mass spectrometry (LC–MS/MS) was used for analyzing. Results: Fifty-seven EV-derived proteins related to NSCLC were highlighted in this research. Some of them have not been addressed before, such as EEF1A1 (elongation factor 1-α1), KPNB1 (Importin subunit beta 1), SRC (proto-oncogene tyrosine-protein kinase) and ACTC1 (actin, alpha cardiac muscle 1). This list was further confirmed through a comparison with ExoCarta and Vesiclepedia. Conclusion: This study is the first work to show the involvement of several novel proteins of small EV (EEF1A1, KPNB1, SRC, and ACTC1) in the progression of NSCLC. The results suggested that they could serve as novel biomarkers for non-small cell lung cancer in the future. 相似文献
2.
3.
4.
Peffault de Latour Rgis Huynh Lynn Ivanova Jasmina I. Totev Todor Bilginsoy Mehmet Antin Joseph Roy Anuja Duh Mei Sheng 《Annals of hematology》2020,99(4):743-752
Annals of Hematology - This study assessed treatment patterns and healthcare resource utilization (HRU) of patients with severe aplastic anemia (SAA) with insufficient response to immunosuppressive... 相似文献
5.
Ognen Ivanovski Thao Nguyen-Khoa Olivier Phan Ziad A Massy 《Nephrology, dialysis, transplantation》2004,19(4):1013-4; author reply 1014
Sir, We read with interest the recent article by Buzello et al. [1]on renal changes in apo E-/- mice after subtotal nephrectomy.They compared renal lesion development in male wild-type C57BL/6mice with that of genetically modified male apo E-/- mice aftereither sham operation, unilateral nephrectomy or subtotal nephrectomy(SNX) by removal of 75% of the cortex in one kidney and removalof the contralateral kidney. They found 相似文献
6.
Bruno Fautrel Thao Pham Gaël Mouterde Xavier Le Loët Philippe Goupille Francis Guillemin Philippe Ravaud Alain Cantagrel Maxime Dougados Xavier Puchal Jean Sibilia Martin Soubrier Xavier Mariette Bernard Combe pour le Club rhumatismes et inflammation pour la Socit franaise de rhumatologie 《Revue du Rhumatisme》2007,74(12):1301-1311
7.
Shinichi Suzuki Cornelius A Davis Charles C Miller Tam T T Huynh Anthony L Estrera Eyal E Porat Anders Vinnerkvist Hazim J Safi 《European journal of cardio-thoracic surgery》2003,24(1):119-24; discussion 124
OBJECTIVE: Previous studies have identified age, renal failure and aneurysm extent as predictors of mortality following thoracoabdominal and descending thoracic aortic aneurysm (TAA) repair. We studied the impact of coronary artery disease (CAD) and cardiac function on 30-day mortality following TAA repair. METHODS: Between February 1991 and May 2001, we performed 854 TAA repairs. Two hundred ninety-one patients (34%) had a history of coronary artery disease. One hundred forty-one/291 (49%) had undergone coronary artery bypass surgery (CAB) prior to TAA repair. We conducted multivariable analyses of known risk factors along with the left ventricular ejection fraction (EF) and prior CAB to determine the adjusted effect of CAD on outcome. RESULTS: Mortality in patients with CAD was 54/291 (18%) compared to 75/563 (13%) without CAD (P<0.05). In patients who had prior CAB, mortality was 31/141 (22%) compared to 98/713 (14%) patients without prior CAB, (P<0.02). In multivariable analysis, the effects of CAD and CAB on mortality were eliminated by consideration of a low EF (defined as less than 50%). CONCLUSION: Impaired left ventricular function appears to be the strongest cardiac predictor of mortality for TAA repair, independent of the presence of coronary artery disease or coronary artery bypass revascularization. 相似文献
8.
Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci 总被引:6,自引:0,他引:6
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Diekema DJ Andrews JI Huynh H Rhomberg PR Doktor SR Beyer J Shortridge VD Flamm RK Jones RN Pfaller MA 《Journal of clinical microbiology》2003,41(6):2659-2661
Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS. 相似文献
9.
Clinical evaluation of a frozen commercially prepared microdilution panel for antifungal susceptibility testing of seven antifungal agents, including the new triazoles posaconazole, ravuconazole, and voriconazole
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Pfaller MA Diekema DJ Messer SA Boyken L Huynh H Hollis RJ 《Journal of clinical microbiology》2002,40(5):1694-1697
A commercially prepared frozen broth microdilution panel (Trek Diagnostic Systems, Westlake, Ohio) was compared with a reference microdilution panel for antifungal susceptibility testing of two quality control (QC) strains and 99 clinical isolates of Candida spp. The antifungal agents tested included amphotericin B, flucytosine, fluconazole, itraconazole, posaconazole, ravuconazole, and voriconazole. Microdilution testing was performed according to NCCLS recommendations. MIC endpoints were read visually after 48 h of incubation and were assessed independently for each microdilution panel. The MICs for the QC strains were within published limits for both the reference and Trek microdilution panels. Discrepancies among MIC endpoints of no more than 2 dilutions were used to calculate the percent agreement. Acceptable levels of agreement between the Trek and reference panels were observed for all antifungal agents tested against the 99 clinical isolates. The overall agreement for each antifungal agent ranged from 96% for ravuconazole to 100% for amphotericin B. The Trek microdilution panel appears to be a viable alternative to frozen microdilution panels prepared in-house. 相似文献
10.
Tan PH Jayabaskar T Chuah KL Lee HY Tan Y Hilmy M Hung H Selvarajan S Bay BH 《American journal of clinical pathology》2005,123(4):529-540
We aimed to establish whether morphologic parameters were prognostically important in a large series of breast phyllodes tumors in Asian women. Of 335 phyllodes tumors diagnosed at the Department of Pathology, Singapore General Hospital, Singapore, between January 1992 and December 2002, 250 (74.6%) were benign, 54 (16.1%) borderline, and 31 (9.3%) malignant, based on histologic review of archival slides. Of the women, 43 (12.8%) experienced recurrences during the follow-up period. Recurrent disease was correlated with grade or classification (P = .028), stromal atypia (P = .016), stromal hypercellularity (P = .046), and permeative microscopic borders (P = .021). Multivariate analysis revealed that independent predictors of recurrence were pseudoangiomatous stromal hyperplasia (PASH) and margin status, whereby the presence of PASH and complete or negative margins reduced recurrence hazards by 51.3% and 51.7% respectively. The 7 women who died of disease during follow-up had malignant phyllodes tumor at the outset and experienced recurrences, and death was preceded by distant metastases. 相似文献