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排序方式: 共有98条查询结果,搜索用时 15 毫秒
1.
Natalia Podzolkova Tetiana Tatarchuk Aikerm Doshchanova Gulsara Eshimbetova 《Gynecological endocrinology》2016,32(3):246-249
Dydrogesterone is an oral retroprogesterone widely used to treat progesterone deficiencies, including irregular menstrual cycles (MCs). This prospective, non-interventional, single-arm, post-marketing, observational study evaluated the effects of dydrogesterone on MC regularization. Women aged 18–40 years who had been prescribed dydrogesterone to treat irregular MCs due to progesterone deficiency were enrolled across 64 centers in Russia, Ukraine, Kazakhstan and Uzbekistan. Study objectives included: patients reporting ≥1 regular MC during treatment; the number of regular MCs after the end of treatment over a 6-month follow-up (FU) period. In total, 996 women were enrolled. Of those who completed treatment, 946/955 patients (99.1%) achieved ≥1 regular MC. During FU, 680/860 patients (79.1%) maintained ≥6 regular MCs. Patient grading of menstrual pain and anxiety decreased significantly during treatment (p?≤?0.0001 versus baseline); this persisted during FU. Dydrogesterone was associated with high or very high patient satisfaction (856/955; 89.6%); the clinical response was considered good or excellent in 819/955 patients (85.8%). In total, 16/986 patients (1.6%) reported an adverse event (AE); two had serious AEs (SAEs) (unrelated to treatment) and three discontinued treatment due to non-SAEs. Dydrogesterone therapy was effective in achieving MC regularization and reducing menstrual pain and anxiety, during both treatment and 6-month FU. 相似文献
2.
Tetiana Kiriazova Karsten Lunze Anita Raj Natalia Bushara Elena Blokhina Evgeny Krupitsky 《AIDS care》2017,29(5):559-563
Many HIV-positive people who inject drugs (PWID) globally are not receiving HIV care. This represents a major challenge among key populations to end the global HIV epidemic. This qualitative study explored the process and associated barriers of linking HIV-positive PWID who are in addiction treatment to HIV care in St. Petersburg, Russia. We conducted three focus groups and seven semi-structured interviews with participants in the LINC (“Linking Infectious and Narcology Care”) project at addiction and HIV hospitals in St. Petersburg. The sample consisted of 25 HIV-infected patients with opioid dependence and seven health-care providers, including addiction and infectious disease physicians and case managers. A variety of intertwining factors influence effective engagement of PWID with HIV treatment. Stigma, problematic patient–provider relationships, and fragmented health care were the main challenges for HIV care initiation by PWID, which were further exacerbated by injection drug use. Effective linkage of PWID to HIV care requires acknowledging and addressing stigma’s role and different perspectives of patients and providers. 相似文献
3.
Yadhav A. Imrit Hanusha Bhakhoa Tetiana Sergeieva Sergi Dans Nandini Savoo Mohamed I. Elzagheid Lydia Rhyman Diego M. Andrada Ponnadurai Ramasami 《RSC advances》2020,10(47):27884
A-234, [EtO–P( O)(F)–N C(Me)–N(Et)2], is the suspected A-type nerve agent used in the Skripal attack on the 4th of March 2018. Studies related to the structure and reactivity of this compound are limited. We, therefore, aimed at understanding the underlying hydrolysis mechanism of A-234 within the DFT framework. The attack of the water molecule can occur at the phosphinate and acetoamidine reactive centres. Our theoretical findings indicate that the hydrolysis at the acetoamidine centre is thermodynamically favoured compared to the hydrolysis at the phosphinate centre. The hydrolysis at the acetoamidine moiety may proceed via two pathways, depending on the nitrogen atom participating in the hydrolysis. The main pathway consists of four distinct channels to reach the final product, with the concerted 1,3-proton shift favoured kinetically and thermodynamically in the gas phase and water as solvent. The results are in good agreement with the literature, although some differences in the reaction mechanism were observed.A theoretical study of the hydrolysis mechanism of A-234 [EtO–P( O)(F)–N C(Me)–N(Et)2]; the suspected novichok agent in the Skripal attack. 相似文献
4.
Butov Dmytro Feshchenko Yurii Myasoedov Valeriy Kuzhko Mykhailo Gumeniuk Mykola Gumeniuk Galyna Tkachenko Anton Nataliya Nekrasova Borysova Olena Butova Tetiana 《Wiener Medizinische Wochenschrift》2022,172(11-12):261-267
Wiener Medizinische Wochenschrift - This study assessed the effectiveness and diagnostic significance of hypertonic saline sputum induction for improving Mycobacterium tuberculosis (MTB) detection.... 相似文献
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Nuclear factor of activated T cells balances angiogenesis activation and inhibition 总被引:10,自引:0,他引:10
Zaichuk TA Shroff EH Emmanuel R Filleur S Nelius T Volpert OV 《The Journal of experimental medicine》2004,199(11):1513-1522
8.
Nico Angliker Michael Burri Mariana Zaichuk Jean‐Marc Fritschy Markus A. Rüegg 《The European journal of neuroscience》2015,42(8):2595-2612
The mammalian target of rapamycin (mTOR) is a key regulator of cellular growth which associates with other proteins to form two multi‐protein complexes called mTORC1 and mTORC2. Dysregulation of mTORC1 signalling in brain is implicated in neuropathological conditions such as autism spectrum or neurodegenerative disorders. Accordingly, allosteric mTOR inhibitors are currently in clinical trials for the treatment of such disorders. Here, we ablated either mTORC1 or mTORC2 conditionally in Purkinje cells of the mouse cerebellum to dissect their role in the development, function and survival of these neurons. We find that the two mouse models largely differ from each other by phenotype and cellular responses. Inactivation of mTORC2, but not of mTORC1, led to motor coordination deficits at an early age. This phenotype correlated with developmental deficits in climbing fibre elimination and impaired dendritic self‐avoidance in mTORC2‐deficient Purkinje cells. In contrast, inactivation of mTORC1, but not of mTORC2, affected social interest of the mice and caused a progressive loss of Purkinje cells due to apoptosis. This cell loss was paralleled by age‐dependent motor deficits. Comparison of mTORC1‐deficient Purkinje cells with those deficient for the mTORC1 inhibitor TSC1 revealed a striking overlap in Purkinje cell degeneration and death, which included neurofilamentopathy and reactive gliosis. Altogether, our study reveals distinct roles of mTORC1 and mTORC2 in Purkinje cells for mouse behaviour and the survival of neurons. Our study also highlights a convergence between the phenotypes of Purkinje cells lacking mTORC1 activity and those expressing constitutively active mTORC1 due to TSC1 deficiency. 相似文献
9.
Tetiana I Bogdanova Liudmyla Yu Zurnadzhy Yuri E Nikiforov Rebecca J Leeman-Neill Mykola D Tronko Stephen Chanock Kiyohiko Mabuchi Ilya A Likhtarov Leonila M Kovgan Vladimir Drozdovitch Mark P Little Maureen Hatch Lydia B Zablotska Viktor M Shpak Robert J McConnell Alina V Brenner 《British journal of cancer》2015,113(11):1556-1564