全文获取类型
收费全文 | 3645篇 |
免费 | 228篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 79篇 |
妇产科学 | 23篇 |
基础医学 | 496篇 |
口腔科学 | 50篇 |
临床医学 | 267篇 |
内科学 | 1014篇 |
皮肤病学 | 53篇 |
神经病学 | 232篇 |
特种医学 | 190篇 |
外科学 | 653篇 |
综合类 | 24篇 |
预防医学 | 142篇 |
眼科学 | 22篇 |
药学 | 235篇 |
中国医学 | 20篇 |
肿瘤学 | 372篇 |
出版年
2023年 | 16篇 |
2022年 | 77篇 |
2021年 | 112篇 |
2020年 | 70篇 |
2019年 | 97篇 |
2018年 | 108篇 |
2017年 | 89篇 |
2016年 | 101篇 |
2015年 | 86篇 |
2014年 | 134篇 |
2013年 | 162篇 |
2012年 | 250篇 |
2011年 | 275篇 |
2010年 | 170篇 |
2009年 | 144篇 |
2008年 | 220篇 |
2007年 | 225篇 |
2006年 | 237篇 |
2005年 | 207篇 |
2004年 | 178篇 |
2003年 | 213篇 |
2002年 | 160篇 |
2001年 | 71篇 |
2000年 | 45篇 |
1999年 | 48篇 |
1998年 | 23篇 |
1997年 | 37篇 |
1996年 | 22篇 |
1995年 | 28篇 |
1994年 | 18篇 |
1993年 | 18篇 |
1992年 | 30篇 |
1991年 | 14篇 |
1990年 | 18篇 |
1989年 | 20篇 |
1988年 | 21篇 |
1987年 | 18篇 |
1986年 | 12篇 |
1985年 | 16篇 |
1984年 | 7篇 |
1983年 | 10篇 |
1982年 | 6篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1974年 | 7篇 |
1973年 | 7篇 |
1972年 | 7篇 |
1970年 | 8篇 |
1967年 | 4篇 |
1965年 | 4篇 |
排序方式: 共有3904条查询结果,搜索用时 15 毫秒
1.
Nobuhiko Joki Hiroki Hase Yuri Tanaka Yasunori Takahashi Tomokatsu Saijyo Hiroyaou Ishikawa Yoji Inishi Yoshihiko Imamura Hisao Hara Taro Tsunoda Masato Nakamura 《Nephrology, dialysis, transplantation》2006,21(6):1633-1639
BACKGROUND: In patients with chronic kidney disease (CKD), although strong associations have been observed between malnutrition and atherosclerosis, the relationship between serum albumin concentration and angiographic changes of coronary artery disease (CAD) remains poorly explored. The goal of the present study was, in patients with CKD, to clarify the relationship between the angiographic severity of CAD and serum albumin concentration reflecting either inflammation or nutrition or both. METHODS: In this study, 100 end-stage renal disease (ESRD) patients were enrolled, who commenced long-term dialysis therapy at our hospital and underwent coronary angiography within 3 months of the first haemodialysis (HD) session. Mean age was 63+/-11 years, 20% of the subjects were female and 62% had diabetes. Severity of CAD was evaluated in terms of (i) number of vessels exhibiting CAD (>or=75% stenosis) and (ii) Gensini score (GS). Clinical characteristics and laboratory findings were recorded at initiation of long-term HD therapy. We then evaluated a possible association with the presence and degree of CAD. RESULTS: Sixty-four patients exhibited signs of CAD. Forty-one among them (64%) had multivessel disease. On univariate logistic regression analysis, age, diabetes and hypoalbuminaemia were significantly associated with multivessel CAD. Univariate linear regression analysis demonstrated a positive correlation of age and diabetes with GS, and an inverse correlation of BMI and serum albumin level with GS. Stepwise regression analysis showed age and serum albumin level to be independently associated with multivessel CAD and GS. The ROC curves demonstrated best cut-off levels of age and albumin for predicting multivessel CAD to be 70 years and 3.15 g/dl, respectively. CONCLUSION: Hypoalbuminaemia at the initiation of dialysis is an important predictor of advanced CAD, particularly in male and in diabetic patients. It may reflect mainly a state of inflammation. However, malnutrition as a confounding factor cannot be entirely excluded. 相似文献
2.
Toru Takahashi Yutaka Hasegawa Kiyohiro Ohshima Taro Nameki Yasuo Morishita 《Annals of thoracic and cardiovascular surgery》2005,11(4):245-248
Although aortic valve replacement (AVR) is an effective treatment for patients with aortic valvular disease, the implantation of a small aortic prosthesis may result in residual left ventricular outflow stenosis and transvalvular gradient. In this study, the outcome in the long-term period of patients treated with a small aortic prosthesis was analyzed retrospectively. Twenty-four patients with AVR were divided into two groups, group A and group B. Group A consisted of 16 patients with 21 mm-sized prosthetic valves, and group B consisted of 8 patients with 19 or 16 mm-sized prosthetic valves. There were no significant differences in preoperative cardiac function or operative procedure in the two groups. The mean follow-up period (months) was 55.0 in group A and 51.3 in group B. RESULTS: One patient died of cerebral infarction in group A. There were no significant differences in cardiothoracic ratio (CTR), left ventricular ejection fraction (LVEF), and left ventricular mass index (LVMI) between the two groups. Postoperative physical activity according to the New York Heart Association (NYHA) classification showed no significant differences in the two groups. Despite using a small prostheses for AVR, the postoperative course was good in the long-term period, although careful follow-up is necessary. 相似文献
3.
4.
Solitary fibrous tumors (SFT) have recently been established to be of mesenchymal origin. Although there are numerous reports
of SFTs arising from the pleura, reports of the tumor arising from extrapleural sites are comparatively rare [Fletcher CDM,
Unni K, Mertens F (eds) World Health Organization classification of tumors, pathology & genetics, tumors of soft tissue and bone. IARC Press, Lyon, pp 86–901, 2002]. We report a case of SFT arising in the inguinal region. 相似文献
5.
Kazumichi Yamada Satoshi Goto Taro Oyama Makoto Yoshikawa Shinji Nagahiro Yukitaka Ushio 《Acta neuropathologica》1995,89(2):172-177
The present study concerns the vulnerability of striatal interneurons immunopositive for the Ca2+-binding protein calretinin to ischemic neuronal injury. An immunohistochemical study was carried out on the striata of rats which had undergone transient middle cerebral artery occlusion. Two weeks after the ischemia, there was a marked reduction in the number of calretinin-positive neurons in the ipsilateral ischemic lesion, although the striatal interneurons positive for parvalbumin, which are a neuronal population distinct from the calretinin-immunoreactive cells in the striatum, were spared in the insulted areas. The present data indicate that the striatal calretinin-positive neurons are less resistant to transient ischemia, suggesting that there may exist vulnerability differences among the striatal interneurons in ischemia-induced neuronal injury. 相似文献
6.
Kazuya Tamai MD PhD Minoru Yamato MD PhD 《Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]》1997,6(6):534
We studied 16 patients (18 shoulders) with frozen shoulders, 8 patients with subacromial impingement syndrome, and 3 healthy volunteers with dynamic magnetic resonance imaging enhanced with gadolinium diethylenetriaminepentaacetic acid. After intravenous contrast was administered, gradient-recalled echo images were obtained in the oblique coronal plane every 11 to 13 seconds for a total period of 4 to 5 minutes. The signal intensity was measured at the periphery of the glenohumeral joint and in the subacromial bursa. The coefficient of enhancement (percent signal increase per second) in the frozen shoulders was 1.33±0.43 (mean ± SD) for the glenohumeral joint and 0.89±0.47 for the subacromial bursa. These values were far greater than those in subacromial impingement syndrome or in the control group, indicating increased blood flow to the synovium in the frozen shoulders. No previous reports have shown a clinical measure related to the pathophysiology of this disease. 相似文献
7.
8.
M Yamato J Ando K Sakaki K Hashigaki Y Wataya S Tsukagoshi T Tashiro T Tsuruo 《Journal of medicinal chemistry》1992,35(2):267-273
Bistropolone derivatives (4-12) containing differing lengths of linkage between the two tropolone rings were prepared and examined for their antitumor activity in in vitro (KB cell) and in vivo (leukemia P388 in mice) systems. Parent compound 3, related compounds previously prepared, and the new compounds 4-12 were evaluated for inhibitory activity against ribonucleotide reductase by indirect means to measure their effects on the dNTP pool imbalance. Present structure-activity relationship results would suggest that potently active bistropolones in vivo inhibit intracellular ribonucleotide reductase through chelating with the two irons at the two active sites of the enzyme. 相似文献
9.
Summary. A man, 79 years of age, developed a malignant fibrous histiocytoma which arose in relation to a calcifying enchondroma of
the distal femur. Radiographs showed a fracture through an intensely calcified bony tumour with no bony destruction. The clinical
diagnosis was a dedifferentiated chondrosarcoma. Histology showed an anaplastic sarcoma with calcified tissue showing extensive
areas of necrosis and degeneration. No chondrosarcomatous foci were found.
Accepted: 9 November 1996 相似文献
Resumé. Nous rapportons le cas d’un homme de 79 ans, qui a développé un histiocytofibrome malin à partir d’un enchodrome calcifié du fémur distal. L’examen radiologique a montré une fracture au sein d’une tumeur très calcifiée sans association de destruction osseuse. Cette lésion apparaissait cliniquement être un chondrosarcome dédifférencié. Mais l’étude histologique a montré un sarcome anaplasique avec un tissu cartilagineux calcifié présentant des plages étendues de nécrose et de dégénérescence. Il n’y avait pas de foyer chondrosarcomateux visible.
Accepted: 9 November 1996 相似文献
10.
T Koike T Hirono T Takizawa Y Yamato T Souma K Yoshiya K Nakayama M Tsuchida S Eguchi 《[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai》1990,38(7):1172-1175
By the end of 1988, seventy five cases after pulmonary resection for lung cancer and one case after pulmonary resection for basal cell hyperplasia were examined with fiberoptic bronchoscopy as postoperative follow up. Endobronchial tumor was detected in 14 cases. In seven cases, endobronchial tumor was located at site far from the surgical bronchial anastomosis. These tumors were suspected as second lung cancer as long as examined by fiberoptic bronchoscopy. Histological type of all of these was squamous cell carcinoma. Re-operations were performed in five cases and two of them were early lung cancer. In 6 cases (13.6%) among 44 cases examined with fiberoptic bronchoscopy after pulmonary resection for central type squamous cell carcinoma, second lung cancer was detected. In the case of central type squamous cell carcinoma, usually the tumor appears to be of same histological type and at same location. Among those cases those who smoke heavily should be separated as high risk group. If this group is followed with fiberoptic bronchoscopy or sputum cytological examination, it is more possible to detect second lung cancer at an early stage. 相似文献