排序方式: 共有19条查询结果,搜索用时 15 毫秒
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Turan Hande Yildiz Mehmet Civan Orkun Cakir Aydilek Dagdeviren Tarcin Gurkan Ozer Yavuz Bayramli Zerengiz Kucur Mine Adaletli Ibrahim Adrovic Amra Barut Kenan Ercan Oya Kasapcopur Ozgur Evliyaoglu Saadet Olcay 《Clinical rheumatology》2021,40(4):1473-1478
Clinical Rheumatology - Although it is well-known that autoimmune thyroid diseases are more common in most of the autoimmune connective tissue diseases, the relationship between autoinflammatory... 相似文献
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Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin Abdullah Sonsuz 《World journal of gastroenterology : WJG》2010,16(18):2223-2226
A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet... 相似文献
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Tahan G Tarcin O Tahan V Eren F Gedik N Sahan E Biberoglu N Guzel S Bozbas A Tozun N Yucel O 《Digestive diseases and sciences》2007,52(12):3348-3354
Stellate cells are activated by free radicals, and synthesize collagen. N-acetylcysteine (NAC) is a precursor of reduced glutathione and a potent scavenger of hydroxyl radicals and has potential
antifibrotic effects. We aimed to test the effects of NAC on bile duct ligation (BDL) induced liver damage in rats. Forty-seven
Wistar rats were divided into 5 groups: group 1, BDL + NAC (n = 10); group 2, BDL (n = 10); group 3, sham + NAC (n = 10); group 4, sham (n = 10); and group 5, control group (n = 10). NAC (50 μmol/kg per day) or saline of single doses were administered intraperitoneally for 28 days. Serum biochemical
and liver oxidative stress parameters were studied. Liver collagen level was determined by the method of Lopez de Leon and
Rojkind. Liver slides were stained by hematoxylin and eosin and Masson trichrome\Gomory reticulum staining. Aspartate aminotransferase
(AST) and alkaline phosphatase levels in the BDL + NAC group were lower than the BDL group and were higher than the control
groups (all P < .001). Malondialdehyde, luminal, and glutathione levels in group 1 were lower than the BDL group (P = .01, P = .002, and P < .001) and higher than the control groups (all P < .001). NAC had no effect on alanine aminotransferase (ALT), gammaglutamyl transferase, bilirubin, albumin, or lucigenin
levels. Liver collagen levels were higher in the BDL groups (P < .001); however, NAC had no effect on the collagen levels. The BDL groups showed stage 3 fibrosis; all the control groups
were normal. NAC improved some biochemical parameters (AST, alkaline phosphatase) and oxidative stress parameters (malondialdehyde,
luminol, glutathione) in the BDL model. NAC was found to be effective on cholestasis-induced hepatotoxicity. However, NAC
was inefficient as an antifibrotic agent within a 1-month period of administration in the BDL model. 相似文献
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Tarcin O 《Gastrointestinal endoscopy》2006,63(2):325-6; discussion 326
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Veysel Tahan Ozlen Atug Hakan Akin Fatih Eren Gulgun Tahan Ozlem Tarcin Hafize Uzun Osman Ozdogan Orhan Tarcin Nese Imeryuz Fehmi Ozguner Cigdem Celikel Erol Avsar Nurdan Tozun 《Journal of pineal research》2009,46(4):401-407
Abstract: Nonalcoholic steatohepatitis (NASH) may progress to advanced fibrosis and cirrhosis. Mainly, oxidative stress and excessive hepatocyte apoptosis are implicated in the pathogenesis of progressive NASH. Melatonin is not only a powerful antioxidant but also an anti-inflammatory and anti-apoptotic agent. We aimed to evaluate the effects of melatonin on methionine- and choline-deficient diet (MCDD)-induced NASH in rats. Thirty-two male Wistar rats were divided into four groups. Two groups were fed with MCDD while the other two groups were fed a control diet, pair-fed. One of the MCDD groups and one of the control diet groups were administered melatonin 50 mg/kg/day intraperitoneally, and the controls were given a vehicle. After 1 month the liver tissue oxidative stress markers, proinflammatory cytokines and hepatocyte apoptosis were studied by commercially available kits. For grading and staging histological lesions, Brunt et al.'s system was used. Melatonin decreased oxidative stress, proinflammatory cytokines and hepatocyte apoptosis. The drug ameliorated the grade of NASH. The present study suggests that melatonin functions as a potent antioxidant, anti-inflammatory and antiapoptotic agent in NASH and may be a therapeutic option. 相似文献
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