全文获取类型
收费全文 | 3196篇 |
免费 | 161篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 58篇 |
妇产科学 | 89篇 |
基础医学 | 375篇 |
口腔科学 | 87篇 |
临床医学 | 187篇 |
内科学 | 794篇 |
皮肤病学 | 50篇 |
神经病学 | 392篇 |
特种医学 | 227篇 |
外科学 | 451篇 |
综合类 | 35篇 |
预防医学 | 91篇 |
眼科学 | 20篇 |
药学 | 166篇 |
中国医学 | 5篇 |
肿瘤学 | 292篇 |
出版年
2021年 | 53篇 |
2020年 | 31篇 |
2019年 | 43篇 |
2018年 | 61篇 |
2017年 | 60篇 |
2016年 | 69篇 |
2015年 | 67篇 |
2014年 | 78篇 |
2013年 | 109篇 |
2012年 | 122篇 |
2011年 | 148篇 |
2010年 | 71篇 |
2009年 | 76篇 |
2008年 | 107篇 |
2007年 | 161篇 |
2006年 | 142篇 |
2005年 | 135篇 |
2004年 | 182篇 |
2003年 | 146篇 |
2002年 | 146篇 |
2001年 | 114篇 |
2000年 | 141篇 |
1999年 | 132篇 |
1998年 | 40篇 |
1997年 | 39篇 |
1996年 | 42篇 |
1995年 | 39篇 |
1994年 | 23篇 |
1993年 | 15篇 |
1992年 | 68篇 |
1991年 | 57篇 |
1990年 | 47篇 |
1989年 | 69篇 |
1988年 | 65篇 |
1987年 | 59篇 |
1986年 | 53篇 |
1985年 | 55篇 |
1984年 | 41篇 |
1983年 | 22篇 |
1982年 | 15篇 |
1980年 | 12篇 |
1979年 | 35篇 |
1978年 | 17篇 |
1975年 | 13篇 |
1974年 | 18篇 |
1973年 | 14篇 |
1972年 | 14篇 |
1970年 | 13篇 |
1969年 | 12篇 |
1968年 | 13篇 |
排序方式: 共有3372条查询结果,搜索用时 218 毫秒
1.
K. Nishiyama S. Murayama Y. Nishimura K. Asayama I. Kanazawa 《Acta neuropathologica》1996,93(1):19-23
Iron accumulation in the basal ganglia and spheroid formation are pathological hallmarks of Hallervorden-Spatz disease (HS).
Since an overaccumulation of iron (iron thesaurosis) that exceeds the binding capacity of ferritin could cause oxidative damage,
we studied the possible role of oxidative stress in the pathogenesis of HS. The basal ganglia and spinal cord from patients
with HS were investigated at autopsy, using histochemistry for iron and immunohistochemistry for Cu/Zn superoxide dismutase
(SOD1), Mn superoxide dismutase (SOD2) and ferritin. SOD1-like immunoreactivity (IR), SOD2-IR and ferritin-IR occurred frequently
in spheroids observed in the basal ganglia, and associated iron accumulation indicated the possible existence of increased
oxidative stress in HS patients. Spheroids in the spinal cord showed intense SOD1-IR and SOD2-IR in HS, in sharp contrast
with the occasional weak SOD1-IR and SOD2-IR observed in spheroids from patients with amyotrophic lateral sclerosis (ALS).
Neither increased ferritin-IR nor iron accumulation were observed in spinal spheroids from HS and ALS patients. These data
may suggest that, at least in the spinal cord, SOD1-IR and SOD2-IR in spheroids in HS patients do not result from oxidative
stress directly related to iron accumulation.
Received: 15 March 1996 / Revised accepted: 15 July 1996 相似文献
2.
Toru Yamaguchi Ippei Kanazawa Masahiro Yamamoto Soichi Kurioka Mika Yamauchi Shozo Yano Toshitsugu Sugimoto 《BONE》2009,44(2):174-179
The association of bone with the metabolic syndrome and its features, visceral fat accumulation or insulin resistance, remains unclear. We determined visceral and subcutaneous fat areas (V and S) by computed tomography on 187 men (28–83 years) and 125 postmenopausal women (46–82 years) with type 2 diabetes. Men whose V was 100 cm2 or more had significantly lower urinary N-terminal cross-linked telopeptide of type-I collagen (p = 0.005), higher femoral neck bone mineral density (FN-BMD) (p = 0.004), and lower prevalence of vertebral fractures (VFs) (p = 0.04) than controls. Fat mass, V, S, and lean body mass positively correlated with FN-BMD in men and with lumbar (L) and FN-BMD in women. When adjusted for weight, these correlations became negative. Urinary C-peptide positively correlated with FN-BMD in both genders. Multivariate logistic regression analysis adjusted for age, height, weight, L-BMD, duration of diabetes, and diabetes therapies identified V in men and urinary C-peptide in women as factors inversely associated with the presence of VFs [odds ratio (OR) = 0.61 per SD increase, p = 0.04, and OR = 0.32, p = 0.01, respectively]. These findings suggest that, of the components of the metabolic syndrome, body fat in gravity and hyperinsulinemia could increase FN-BMD in diabetic subjects. Visceral fat in men and hyperinsulinemia in women may protect against VFs independent of weight, L-BMD, diabetes duration, or therapies. 相似文献
3.
4.
5.
Susumu Kusunoki Atsuro Chiba Seiji Hitoshi Hajime Takizawa Ichiro Kanazawa 《Muscle & nerve》1995,18(4):409-413
Four of 82 patients with Guillain-Barré syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal-C). Two patients with GBS without mycoplasma infection also had anti-Gal-C antibody, whereas none of the normal or the disease controls had it. As Gal-C is a major glycolipid antigen in myelin, anti-Gal-C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies. Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti-Gal-C antibody. © 1995 John Wiley & Sons, Inc. 相似文献
6.
Summary The histogenesis of stromal cells in capillary hemangioblastoma has been the subject of debate. The light and electron microscopic studies of hemangioblastomas presented here showed pericytic and leiomyoblastic features in stromal cells. Cells cultured by the monolayer method showed similar features to those of the original tumors. Immunohistochemical studies for glial fibrillary acidic protein and factor VIII/von Willebrand factor indicated that stromal cells were antigenically distinct from astrocytes and endothelial cells. These findings suggest that stromal cells are closely related to pericytes and smooth muscle cells, and support Rhodin's speculation that pericytes serve as a precursor to smooth muscle cells. 相似文献
7.
8.
Yasushi NAKAGAWA Shinobu TSUKAMOTO Miho MIYAZAKI Chiyuki NAKAGAWA Takeharu YAMANAKA Norifumi YAMASHITA Akito NOHTOMI 《Psychogeriatrics》2003,3(3):104-108
Background: In Japan a new long‐term care insurance (LTCI) system, the so‐called ‘Kaigo‐Hoken’, was started in April 2000. The present study analyzes the change in the type of destination after discharge from a senile dementia therapy ward before and after the implementation of LTCI at Fukuoka Prefectural Onga Hospital, Japan. Methods: The present study examines data from 199 inpatients discharged from the Fukuoka Prefectural Onga Hospital that had been diagnosed with dementia and met the DSM IV criteria for Alzheimer's type, vascular dementia or other type of dementia. For the purposes of comparison two periods were defined, ‘the first period’ was defined as the period from 1 April 1999 to 31 March 2000, before LTCI was implemented, while ‘the second period’ was defined as the period from 1 April 2000 to 31 March 2001, after LTCI had started. Subject data was analyzed on the basis of where the subject had resided pre‐admission and their destination after discharge using the following classifications: nursing home or geriatric care facility, hospitalization, home and death. Results: While the certification rate of inpatients regarding long‐term care increased slightly in the second period, no significant change was observed based on where the subject had resided pre‐admission and their destination after discharge between the first and second periods. Conclusions: While LTCI is essential for Japan, it is necessary that people with dementia in senile dementia therapy wards are encouraged to return to their homes under the care and support of LTCI. 相似文献
9.
Extracardiac Direct Total Cavopulmonary Connection 总被引:2,自引:0,他引:2
Masaaki Yamagishi MD Yuzuru Nakamura MD Toshiyuki Kanazawa MD Noriyasu Kawada MD 《The Annals of thoracic surgery》1997,64(6):1817-1819
We report a successful extracardiac direct total cavopulmonary connection without prosthetic materials performed in a 3-year-old boy with tricuspid atresia, infundibular pulmonary stenosis, and normally positioned great arteries. The transected pulmonary trunk was bought down posterolaterally with respect to the right atrium and was anastomosed end-to-end with the inferior vena cava. 相似文献
10.