全文获取类型
收费全文 | 2390篇 |
免费 | 189篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 118篇 |
妇产科学 | 63篇 |
基础医学 | 187篇 |
口腔科学 | 108篇 |
临床医学 | 279篇 |
内科学 | 401篇 |
皮肤病学 | 213篇 |
神经病学 | 147篇 |
特种医学 | 177篇 |
外科学 | 361篇 |
综合类 | 45篇 |
一般理论 | 1篇 |
预防医学 | 113篇 |
眼科学 | 82篇 |
药学 | 135篇 |
中国医学 | 24篇 |
肿瘤学 | 123篇 |
出版年
2023年 | 22篇 |
2022年 | 24篇 |
2021年 | 61篇 |
2020年 | 48篇 |
2019年 | 73篇 |
2018年 | 92篇 |
2017年 | 77篇 |
2016年 | 68篇 |
2015年 | 90篇 |
2014年 | 97篇 |
2013年 | 133篇 |
2012年 | 153篇 |
2011年 | 183篇 |
2010年 | 97篇 |
2009年 | 58篇 |
2008年 | 107篇 |
2007年 | 156篇 |
2006年 | 111篇 |
2005年 | 119篇 |
2004年 | 112篇 |
2003年 | 90篇 |
2002年 | 113篇 |
2001年 | 74篇 |
2000年 | 70篇 |
1999年 | 45篇 |
1998年 | 39篇 |
1997年 | 30篇 |
1996年 | 33篇 |
1995年 | 14篇 |
1994年 | 24篇 |
1993年 | 12篇 |
1992年 | 23篇 |
1991年 | 26篇 |
1990年 | 14篇 |
1989年 | 18篇 |
1988年 | 16篇 |
1987年 | 9篇 |
1986年 | 20篇 |
1985年 | 14篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 6篇 |
1979年 | 5篇 |
1977年 | 6篇 |
1973年 | 3篇 |
1970年 | 4篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1966年 | 4篇 |
排序方式: 共有2633条查询结果,搜索用时 828 毫秒
1.
2.
Quang Ngoc Nguyen Linh Dieu Vuong Van-Long Truong To Van Ta Nam Trung Nguyen Hung Phi Nguyen Ha Hoang Chu 《Pathology, research and practice》2019,215(5):885-892
Genetic and epigenetic alterations importantly contribute to the pathogenesis of lung cancer. In the study, we measured the frequency and distribution of molecular abnormalities of EGFR as well as the aberrant promoter methylations of BRCA1, MGMT, MLH1, and RASSF1A in Vietnamese lung adenocarcinomas. We investigated the association between genetic and epigenetic alteration, and between each abnormality with clinicopathologic parameters. Somatic EGFR mutation that was found in 49/139 (35.3%) lung adenocarcinomas showed a significant association with young age, female gender, and non-smokers. EGFR overexpression was identified in 82 tumors (59.0%) and statistical relationships with EGFR or BRCA1 methylation but not EGFR mutation. In addition, EGFR, BRCA1, MGMT, MLH1, and RASSF1A methylations were found in 33 (23.7%), 41 (29.5%), 46 (33.1%), 28 (20.1%), and 41 (29.5%) cases of a total of 139 lung adenocarcinomas, respectively. The RASSF1A methylation was found to be linked to the smoking habit. Methylations in MGMT and RASSF1A were also found to correlate with metastasis status. Furthermore, the distribution of EGFR mutation and that of BRCA1, MGMT or RASSF1A methylation were significantly exclusive in lung adenocarcinomas. The main finding of our study demonstrate that epigenetic abnormalities might play a critical role for the lung tumorigenesis in patients with smoking history and metastasis, and partly affect the predictive value of EGFR mutations through blocking expression due to promoter EGFR hypermethylation. Mutually exclusive distribution of genetic and epigenetic alterations reflects differently biological characteristics in the etiology of lung adenocarcinomas. 相似文献
3.
Stoma Adjustable Silicone Gastric Banding versus Vertical Banded Gastroplasty for the Treatment of Morbid Obesity 总被引:1,自引:0,他引:1
Background: Among gastric restrictive operations, the procedure of choice is still controversial. The aim of this study is
to compare the results of two different gastric restrictive procedures: vertical banded gastroplasty (VBG) and stoma adjustable
silicone gastric banding (ASGB). Methods: Between 1991 and 1996, 51 patients were treated surgically for morbid obesity: 27
underwent VBG and 24 underwent ASGB. Preoperative body weight (BW), body mass index (BMI) and percentage of ideal body weight
(% IBW) were (mean ± SD): 145.7 ± 45.3 kg; 53.9 ± 15.9 kg/m2; 249.1 ± 73.5% respectively in the VBG group. Corresponding figures for the ASBG group were 132.5 ± 22.7 kg; 46.9 ± 7.8 kg/m2 and 207.2 ± 35.0%. Results: In the VBG group, the median follow-up period was 26 months (range: 7-47). Eighteen months after
the operation BW, BMI, % IBW and percentage of excess weight loss (% EWL) were 85.5 ± 26.8 kg, 31.9 ± 9.8 kg/m2, 145.4 ± 43.9% and 74 ± 1% respectively. Complications included incisional hernia (n = 1), and bowel obstruction (n = 1).
One patient died of acute myocardial infarction on the third postoperative day. In the ASGB group, median follow-up time was
19.7 months (range: 18-26). At 18 months postoperation BW, BMI, % IBW and % EWL values were 86.6 ± 20.6 kg 30.6 ± 6.6 kg/m2
140.6 ± 29.3% and 64 ± 1% respectively. Gastric wall erosion occurred in two patients and the bands had to be removed. These
patients underwent VBG 6 months later. Complications encountered in this group were incisional hernia (n = 1), outlet stenosis
and reflux esophagitis (n = 1), reservoir leakage (n = 1) and gastrointestinal bleeding (n = 1). Two patients died of pulmonary
embolism and acute gastrointestinal bleeding. Conclusions: Weight reduction was not statistically significant between the
two groups. ASGB was easier to perform and less invasive than VBG. 相似文献
4.
5.
In 44 patients with one or more calculi in the upper two-thirds of the ureter, single-stage percutaneous nephrolithotomy was performed through a middle or upper calyceal nephrostomy after cystoscopic placement of an occlusion balloon catheter distal to the calculus; in 42, the procedure was successful. The occlusion balloon catheter permitted retrograde opacification of all systems for enhanced renal puncture. In the last 30 patients an attempt was made either to push the calculus upward mechanically or to flush it upward into the renal pelvis with carbon dioxide or dilute contrast material. This was successful in 24 of these patients. Prior overnight occlusion of the ureter by means of ureteral dilatation further facilitates dislodgment of the calculus, which was successful in 12 of 13 patients. 相似文献
6.
Braffman BH; Coleman BG; Ramchandani P; Arger PH; Nodine CF; Dinsmore BJ; Louie A; Betsch SE 《Radiology》1994,190(3):797
7.
8.
K B Ates S Boyacio?lu I Ta? A Gencer G Temu?in B Sahin 《Gastrointestinal radiology》1991,16(2):178-180
Bleeding into a pancreatic pseudocyst is a rare but life-threatening entity. Early diagnosis is crucial in its management. There are reports suggesting that computed tomography (CT), scintigraphy, endoscopic retrograde cholangiopancreatography (ERCP), and angiography could be the diagnostic maneuvers. In this report, we present a case of arterial bleeding into a pancreatic pseudocyst, which was diagnosed by the turbulent echo-currents seen in real-time ultrasonography. 相似文献
9.
Dr. Rüçhan Ergün Ali I. Ökten Muammer Yüksel Bülent Gül Çetin Evliyaoglu Fikret Ergüngör Yamaç Taşkin 《Neurosurgical review》1997,20(1):33-37
Hydatid cysts of central nervous system are rare and comprise only 2% to 3% of all hydatid cysts reported. Orbital localization is very uncommon and has been reported less than 1 % of all hydatid diseases. The primary treatment of hydatid disease is surgical. The most important complication of the surgical treatment is secondary hydatidosis due to spillage of the cyst contents. Because of the difficulties of the orbital localization, total extirpation of the cysts without rupture is almost impossible. Preventing spontaneous rupture of the cysts during surgery and postoperative antihelmintic treatment should be taken into consideration in these cases.This study includes four cases who underwent surgery for orbital hydatid cysts. Radiological characteristics, operative technique and postoperative medical therapy are discussed. 相似文献
10.