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The Relationship between the Profiles of SVC and Sustainability of SVC Fibrillation Induced by Provocative Electrical Stimulation
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TOMOFUMI SANTA KAZUYO NISHIHARA SHIGEO HORIE HAJIME KOTAKI YASUFUMI SAWADA KAZUKI KAWABE TATSUJI IGA 《The Journal of pharmacy and pharmacology》1994,46(7):606-607
Abstract— Recently we observed a case in which the cyclosporin A absorption decreased after treatment with GoLytely lavage solution in a kidney transplant patient. In this study, we confirmed the decrease of the blood concentration of cyclosporin A after oral administration by GoLytely (Macrogol 3350) based on experiments with rats. The peak blood cyclosporin A concentration, and the area under the blood drug concentration-time curve from 0 to 24 h in the GoLytely-administered group were significantly lower than the control group. In the case of gastrointestinal dysfunction such as diarrhoea, or in treatment with laxatives such as GoLytely lavage solution, whole blood cyclosporin levels must be carefully monitored, and intravenous cyclosporin A may be more suitable for providing adequate immunosuppression. 相似文献
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YOSHIO KATAYAMA KENSUKE KOJIMA TADASHI YOSHINO YOSHINOBU MATSUO MASAFUMI ISOKAWA TOMOFUMI YANO HIDEYUKI OKA MIKA YAMAGUCHI SEIGO DEGUCHI JUNJIRO TSUCHIYAMA KYOICHI HAYASHI TAKANORI TESHIMA KATSUJI SHINAGAWA FUMIHIKO ISHIMARU EIJIRO OMOTO & MINE HARADA 《British journal of haematology》1997,97(3):626-634
In two-thirds of patients with splenic lymphoma with villous lymphocytes (SLVL) a small amount of M-protein can be detected in association with the presence of plasma cells in the peripheral blood (PB) and/or bone marrow (BM). However, it is not known whether lymphoma cells and plasma cells originate from the same clone. In this report we describe a case of SLVL which was characterized by the presence of marked monoclonal gammopathy (IgG-κ 90 g/l) and increased plasma cells in the BM. In an attempt to elucidate the origin of lymphoma cells and plasma cells, we performed morphological, cytogenetic and molecular studies on PB mononuclear cells (PBMNC) without plasma cells and BMMNC containing 10% plasma cells from this patient.
Immunofluorescence showed that lymphoma cells and plasma cells were positive for cytoplasmic γ heavy and κ light chains. Well-developed endoplasmic reticulum was observed in the cytoplasmic organelles of PBMNC using an electron microscope. The mean IgG concentration in the 3 d supernatant cultures of PBMNC was 374±24μg/l. More than 50% PBMNC differentiated into plasmacytoid cells in 6 d of liquid culture with IL-3 and IL-6. Analysis by two-colour FISH revealed that karyotypic abnormalities of monosomy X and trisomy 17 existed simultaneously in both lymphoma cells and plasma cells. JH gene rearranged bands from PBMNC and BMMNC by Southern blot hybridization were identical, whereas DNAs from PBMNC failed to hybridize with the Cμ probe.
These observations strongly suggest that lymphoma cells and plasma cells originate from the same clone, and that plasma cells, as well as lymphoma cells, which have undergone class switch recombination, could produce IgG type M-protein in this case. 相似文献
Immunofluorescence showed that lymphoma cells and plasma cells were positive for cytoplasmic γ heavy and κ light chains. Well-developed endoplasmic reticulum was observed in the cytoplasmic organelles of PBMNC using an electron microscope. The mean IgG concentration in the 3 d supernatant cultures of PBMNC was 374±24μg/l. More than 50% PBMNC differentiated into plasmacytoid cells in 6 d of liquid culture with IL-3 and IL-6. Analysis by two-colour FISH revealed that karyotypic abnormalities of monosomy X and trisomy 17 existed simultaneously in both lymphoma cells and plasma cells. JH gene rearranged bands from PBMNC and BMMNC by Southern blot hybridization were identical, whereas DNAs from PBMNC failed to hybridize with the Cμ probe.
These observations strongly suggest that lymphoma cells and plasma cells originate from the same clone, and that plasma cells, as well as lymphoma cells, which have undergone class switch recombination, could produce IgG type M-protein in this case. 相似文献
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Clinical Structural Anatomy of the Inferior Pyramidal Space Reconstructed Within the Cardiac Contour Using Multidetector‐Row Computed Tomography
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SHUMPEI MORI M.D. KOJI FUKUZAWA M.D. Ph.D. TOMOFUMI TAKAYA M.D. Ph.D. SACHIKO TAKAMINE M.D. Ph.D. TATSURO ITO M.D. Ph.D. SEI FUJIWARA M.D. Ph.D. TATSUYA NISHII M.D. Ph.D. ATSUSHI K. KONO M.D. Ph.D. AKIHIRO YOSHIDA M.D. Ph.D. KEN‐ICHI HIRATA M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2015,26(7):705-712
Although many studies have described the detailed anatomy of the inferior pyramidal space, it may not be easy for cardiologists who have few chances to study cadaveric hearts to understand the correct morphology of the structure. The inferior pyramidal space is the part of extracardiac fibro‐adipose tissue wedging between the 4 cardiac chambers from the diaphragmatic surface of the heart. Many cardiologists have interests in pericardial adipose tissue, but the inferior pyramidal space seems to have been neglected. A number of important structures, including the coronary sinus, atrioventricular node, atrioventricular nodal artery, membranous septum, muscular atrioventricular sandwich (previously called the “muscular atrioventricular septum”), atrial septum, ventricular septum, aortic valvar complex, mitral valvar attachment, and tricuspid valvar attachment are associated with the inferior pyramidal space. We previously revealed its 3‐dimensional live anatomy using multidetector‐row computed tomography. Moreover, the 3‐dimensional understanding of the anatomy in association with the cardiac contour is important from the viewpoints of clinical cardiac electrophysiology. The purpose of this article is to demonstrate extended findings regarding the clinical structural anatomy of the inferior pyramidal space, which was reconstructed in combination with the cardiac contour using multidetector‐row computed tomography, and discuss the clinical implications of the findings. 相似文献
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Characteristics of Residual Atrial Posterior Wall and Roof‐Dependent Atrial Tachycardias after Pulmonary Vein Isolation
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AKINORI MATSUMOTO M.D. KOJI FUKUZAWA M.D. KUNIHIKO KIUCHI M.D. F.H.R.S. HIROKI KONISHI M.D. HIROTOSHI ICHIBORI M.D. HIROSHI IMADA M.D. KIYOHIRO HYOGO M.D. JUN KUROSE M.D. TOMOFUMI TAKAYA M.D. SHUMPEI MORI M.D. AKIHIRO YOSHIDA M.D. KEN‐ICHI HIRATA M.D. TATSUYA NISHII M.D. ATSUSHI KONO M.D. 《Pacing and clinical electrophysiology : PACE》2016,39(10):1090-1098
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Slit‐Like Deformation of the Coronary Sinus Orifice due to Compression of the Inferior Pyramidal Space by the Severely Dilated Left Ventricle
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HIROTOSHI ICHIBORI M.D. SHUMPEI MORI M.D. Ph.D. TOMOFUMI TAKAYA M.D. Ph.D. KUNIHIRO KIUCHI M.D. Ph.D. TATSURO ITO M.D. Ph.D. SEI FUJIWARA M.D. Ph.D. KOJI FUKUZAWA M.D. Ph.D. KAZUHIRO TATSUMI M.D. Ph.D. HIDEKAZU TANAKA M.D. Ph.D. TATSUYA NISHII M.D. Ph.D. ATSUSHI K. KONO M.D. Ph.D. KEN‐ICHI HIRATA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(9):1026-1029
The coronary sinus is located within the inferior pyramidal space, which is the part of the epicardial visceral fibroadipose tissue wedging between the four cardiac chambers from the bottom of the heart. Therefore, this region is susceptible to the morphological changes of the cardiac chambers. We present a case of slit‐like deformation of the coronary sinus orifice due to compression of the inferior pyramidal space by the severely dilated left ventricle, which has not been previously described. 相似文献