全文获取类型
收费全文 | 24755篇 |
免费 | 1401篇 |
国内免费 | 97篇 |
专业分类
耳鼻咽喉 | 370篇 |
儿科学 | 458篇 |
妇产科学 | 426篇 |
基础医学 | 3509篇 |
口腔科学 | 2522篇 |
临床医学 | 1912篇 |
内科学 | 5180篇 |
皮肤病学 | 607篇 |
神经病学 | 1854篇 |
特种医学 | 576篇 |
外科学 | 2570篇 |
综合类 | 64篇 |
一般理论 | 8篇 |
预防医学 | 2849篇 |
眼科学 | 345篇 |
药学 | 1904篇 |
中国医学 | 259篇 |
肿瘤学 | 840篇 |
出版年
2023年 | 225篇 |
2022年 | 608篇 |
2021年 | 919篇 |
2020年 | 638篇 |
2019年 | 796篇 |
2018年 | 984篇 |
2017年 | 722篇 |
2016年 | 727篇 |
2015年 | 944篇 |
2014年 | 1219篇 |
2013年 | 1350篇 |
2012年 | 2036篇 |
2011年 | 2343篇 |
2010年 | 1168篇 |
2009年 | 915篇 |
2008年 | 1524篇 |
2007年 | 1533篇 |
2006年 | 1198篇 |
2005年 | 1105篇 |
2004年 | 920篇 |
2003年 | 792篇 |
2002年 | 668篇 |
2001年 | 428篇 |
2000年 | 391篇 |
1999年 | 309篇 |
1998年 | 108篇 |
1997年 | 95篇 |
1996年 | 75篇 |
1995年 | 51篇 |
1994年 | 67篇 |
1993年 | 40篇 |
1992年 | 127篇 |
1991年 | 146篇 |
1990年 | 104篇 |
1989年 | 96篇 |
1988年 | 82篇 |
1987年 | 70篇 |
1986年 | 75篇 |
1985年 | 71篇 |
1984年 | 49篇 |
1983年 | 55篇 |
1982年 | 26篇 |
1980年 | 37篇 |
1979年 | 46篇 |
1977年 | 23篇 |
1973年 | 33篇 |
1971年 | 23篇 |
1970年 | 27篇 |
1968年 | 42篇 |
1966年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Iclea Rocha Gama Euclides Marinho Trindade-Filho Suzana Lima Oliveira Nassib Bezerra Bueno Isabelle Tenório Melo Cyro Rego Cabral-Junior Elenita M. Barros Jaqueline A. Galvão Wanessa S. Pereira Raphaela C. Ferreira Bruna R. Domingos Terezinha da Rocha Ataide 《Metabolic brain disease》2015,30(1):93-98
2.
3.
Talita da Silva Mendes de Farias Ariclécio Cunha de Oliveira Sandra Andreotti Fernanda Gaspar do Amaral Patrícia Chimin André Ricardo Alves de Proença Francisco Leonardo Torres Leal Rogério Antonio Laurato Sertié Amanda Baron Campana Andressa Bolsoni Lopes Arnaldo Henrique de Souza José Cipolla‐Neto Fabio Bessa Lima 《Journal of pineal research》2015,58(3):251-261
Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian manner (24‐hr period), and its oscillation influences several circadian biological rhythms, such as the regulation of clock genes expression (chronobiotic effect) and the modulation of several endocrine functions in peripheral tissues. Assuming that the circadian synchronization of clock genes can play a role in the regulation of energy metabolism and it is influenced by melatonin, our study was designed to assess possible alterations as a consequence of melatonin absence on the circadian expression of clock genes in the epididymal adipose tissue of male Wistar rats and the possible metabolic repercussions to this tissue. Our data show that pinealectomy indeed has impacts on molecular events: it abolishes the daily pattern of the expression of Clock, Per2, and Cry1 clock genes and Pparγ expression, significantly increases the amplitude of daily expression of Rev‐erbα, and affects the pattern of and impairs adipokine production, leading to a decrease in leptin levels. However, regarding some metabolic aspects of adipocyte functions, such as its ability to synthesize triacylglycerols from glucose along 24 hr, was not compromised by pinealectomy, although the daily profile of the lipogenic enzymes expression (ATP‐citrate lyase, malic enzyme, fatty acid synthase, and glucose‐6‐phosphate dehydrogenase) was abolished in pinealectomized animals. 相似文献
4.
5.
6.
C M Kyaw C R De Araujo M R Lima E G S Gondim M M Brígido L G Giugliano 《Infection, genetics and evolution》2003,3(2):111-117
Diffusely adhering Escherichia coli (E. coli) strains (DAEC) represent a potential cause of diarrhoea in infants, and the detection of type three secretion system (TTSS) genes in DAEC would substantiate their pathogenic nature. In this work, four isolates of DAEC, recovered from stools of diarrhoeic children, were analysed by PCR, in order to detect the presence of TTSS genes. Primers targeted to the escC, escJ, escN and escV, some of the most conserved TTSS genes in enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC), were used in order to verify the occurrence of homologous genes in our DAEC isolates. By this approach, we were able to characterise DNA fragments corresponding to putative escJ and escN genes in all DAEC isolates. Furthermore, DNA fragments homologous to the escC and escV genes were also amplified from all isolates. Besides the similarity found among the DAEC esc homologues with EPEC and EHEC esc genes, the nucleotide sequence analysis of the flanking regions of the amplified DNA fragments suggests that the putative DAEC esc genes are organised in the same manner as observed in EPEC and in EHEC strains. The results described here provide strong evidence for the presence of a TTSS in the DAEC strains analysed, implicating a pathogenic nature of these isolates. 相似文献
7.
8.
Milena Soares Santos Guilherme de Sousa Ribeiro Tainara Queiroz Oliveira Renan Cardoso Nery Santos Edilane Gouveia Kátia Salgado Daniele Takahashi Cleuber Fontes Leila Carvalho Campos Mitermayer Galvão Reis Albert Icksang Ko Joice Neves Reis 《International journal of infectious diseases》2009,13(4):456-461
9.
10.