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Nidhi Tandon Surbhi Sidana S. Vincent Rajkumar Angela Dispenzieri Morie A. Gertz Martha Q. Lacy 《Amyloid》2017,24(3):183-188
We analysed factors predicting early treatment failure (ETF), after first-line therapy for light-chain amyloidosis (AL). AL amyloidosis patients seen at Mayo Clinic within 90?days of diagnosis, from 2006 to 2015, excluding those who died within 3 months of initial therapy, were analysed retrospectively. ETF was defined as progression requiring treatment change or death within 12 (ETF12) or 24 (ETF24) months of first-line treatment. Non-ETF included those with a follow-up of more than 12 or 24 months who had progression beyond 12 or 24 months. A total of 724 patients met the study criteria; 244 (33.7%) had ETF12 and 388 (53.6%) had ETF24. Patients with ETF12 were older (64.1 vs. 62.2?years) with higher prevalence of cardiac (81 vs. 64.1%) and multi-organ involvement (67.2 vs. 45.4%) and higher proportion of patients with t(11; 14) (58.5 vs. 44.3%) or in higher Mayo 2012 stage (58.5 vs. 41.1%).The median follow-up was 5.4?years from start of initial therapy. In multivariate analysis, presence of t(11; 14) and non-incorporation of autologous transplant in initial therapy are significant predictors of ETF12 (p?=?.01and p?=?.003) and ETF24 (p?=?.0001 and p?=?.005) while Mayo stage is predictive of ETF24 (p?=?.002), but not ETF12. 相似文献
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Mingling Chen Lisa J. Moran Cheryce L. Harrison Gebresilasea Gendisha Ukke Surbhi Sood Christie J. Bennett Mahnaz Bahri Khomami Pilvikki Absetz Helena Teede Siew Lim 《Obesity reviews》2022,23(1):e13340
The risk of type 2 diabetes mellitus (T2DM) varies by ethnicity, but ethnic differences in response to diabetes prevention interventions remain unclear. This systematic review and meta-analysis assessed ethnic differences in the effects of lifestyle interventions on T2DM incidence, glycemic outcomes (fasting glucose, 2-h glucose, HbA1c), anthropometric measures (weight, BMI, waist circumference), and lifestyle behaviors (physical activity, energy intake, energy from fat, fiber intake). MEDLINE, EMBASE, and other databases were searched (to June 15, 2020) for randomized and non-randomized controlled trials on lifestyle interventions (diet and/or physical activity) in adults at risk of T2DM. Ethnicity was categorized into European, South Asian, East and Southeast Asian, Middle Eastern, Latin American, and African groups. Forty-four studies were included in meta-analyses. Overall, lifestyle interventions resulted in significant improvement in T2DM incidence, glycemic outcomes, anthropometric measures, physical activity, and energy intake (all P < 0.01). Significant subgroup differences by ethnicity were found for 2-h glucose, weight, BMI, and waist circumference (all P < 0.05) but not for T2DM incidence, fasting glucose, HbA1c, and physical activity (all P > 0.05). Few studies in non-European groups reported dietary intake. Lifestyle interventions in different ethnic groups may have similar effects in reducing incidence of T2DM although this needs to be confirmed in further studies. 相似文献
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James Reigle Dina Secic Jacek Biesiada Collin Wetzel Behrouz Shamsaei Johnson Chu Yuanwei Zang Xiang Zhang Nicholas J. Talbot Megan E. Bischoff Yongzhen Zhang Charuhas V. Thakar Krishnanath Gaitonde Abhinav Sidana Hai Bui John T. Cunningham Qing Zhang Laura S. Schmidt W. Marston Linehan Mario Medvedovic David R. Plas Julio A. Landero Figueroa Jarek Meller Maria F. Czyzyk-Krzeska 《The Journal of clinical investigation》2021,131(1)
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Juvenile ossifying fibroma diagnosed on fine needle aspiration cytology: A diagnostic challenge
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Surbhi Goyal M.D. D.N.B. Sonal Sharma M.D. Vipin Arora M.D. 《Diagnostic cytopathology》2015,43(1):75-79
Preoperative diagnosis of jaw lesions is not always possible on the basis of clinico‐radiological findings alone and needs to be confirmed before attempting any surgical intervention. Fibro‐osseous lesions of the jaw comprise a spectrum of diseases which include cement‐osseous dysplasia, fibrous dysplasia, and ossifying fibroma. The cytomorphological distinction between these individual entities is difficult. We present a case of maxillary fibro‐osseous lesion in an adolescent girl diagnosed and categorized as juvenile ossifying fibroma preoperatively on cytology and confirmed on histopathology. Although aspirates are usually paucicellular in fibro‐osseous lesions, certain cytological features if present in cellular cytosmears can offer further categorization and a definitive diagnosis may be possible in light of clinico‐radiological correlation. Diagn. Cytopathol. 2015;43:75–79. © 2014 Wiley Periodicals, Inc. 相似文献
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Graham SM Ahmed T Amanullah F Browning R Cardenas V Casenghi M Cuevas LE Gale M Gie RP Grzemska M Handelsman E Hatherill M Hesseling AC Jean-Philippe P Kampmann B Kabra SK Lienhardt C Lighter-Fisher J Madhi S Makhene M Marais BJ McNeeley DF Menzies H Mitchell C Modi S Mofenson L Musoke P Nachman S Powell C Rigaud M Rouzier V Starke JR Swaminathan S Wingfield C 《The Journal of infectious diseases》2012,205(Z2):S199-S208
There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis. 相似文献
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