全文获取类型
收费全文 | 3512篇 |
免费 | 185篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 76篇 |
妇产科学 | 17篇 |
基础医学 | 354篇 |
口腔科学 | 84篇 |
临床医学 | 216篇 |
内科学 | 1054篇 |
皮肤病学 | 258篇 |
神经病学 | 179篇 |
特种医学 | 77篇 |
外科学 | 724篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 138篇 |
眼科学 | 7篇 |
药学 | 280篇 |
中国医学 | 1篇 |
肿瘤学 | 250篇 |
出版年
2023年 | 17篇 |
2022年 | 29篇 |
2021年 | 49篇 |
2020年 | 25篇 |
2019年 | 36篇 |
2018年 | 82篇 |
2017年 | 70篇 |
2016年 | 80篇 |
2015年 | 60篇 |
2014年 | 92篇 |
2013年 | 125篇 |
2012年 | 185篇 |
2011年 | 206篇 |
2010年 | 96篇 |
2009年 | 87篇 |
2008年 | 165篇 |
2007年 | 172篇 |
2006年 | 176篇 |
2005年 | 180篇 |
2004年 | 175篇 |
2003年 | 152篇 |
2002年 | 163篇 |
2001年 | 105篇 |
2000年 | 112篇 |
1999年 | 135篇 |
1998年 | 70篇 |
1997年 | 49篇 |
1996年 | 39篇 |
1995年 | 26篇 |
1994年 | 26篇 |
1993年 | 28篇 |
1992年 | 80篇 |
1991年 | 79篇 |
1990年 | 62篇 |
1989年 | 64篇 |
1988年 | 50篇 |
1987年 | 34篇 |
1986年 | 34篇 |
1985年 | 37篇 |
1984年 | 26篇 |
1983年 | 28篇 |
1982年 | 14篇 |
1981年 | 14篇 |
1979年 | 24篇 |
1978年 | 18篇 |
1977年 | 18篇 |
1975年 | 15篇 |
1974年 | 16篇 |
1972年 | 17篇 |
1970年 | 11篇 |
排序方式: 共有3733条查询结果,搜索用时 15 毫秒
1.
2.
3.
Koji Saito Takashi Saito Sumio Kawada 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1176, 1179-1176, 1180
4.
5.
6.
Toshiaki Otsuka Tomoyuki Kawada Masao Katsumata Chikao Ibuki Yoshiki Kusama 《Hypertension research》2007,30(12):1211-1218
The second derivative of the finger photoplethysmogram (SDPTG) has been used as a non-invasive examination for arterial stiffness. The present study sought to elucidate independent determinants of the SDPTG among various cardiovascular risk factors in middle-aged Japanese men. The SDPTG was obtained from the cuticle of the left-hand forefinger in 973 male workers (mean age: 44+/-6 years) during a medical checkup at a company. The SDPTG indices (b/a and d/a) were calculated from the height of the wave components. Multiple logistic regression analyses revealed that the independent determinants of an increased b/a (highest quartile of the b/a) were age (odds ratio [OR]: 1.12 per 1-year increase, 95% confidence interval [CI]: 1.09-1.15), hypertension (OR: 1.65, 95% CI: 1.03-2.65), dyslipidemia (OR: 1.51, 95% CI: 1.09-2.09), impaired fasting glucose/diabetes mellitus (OR: 2.43, 95% CI: 1.16-5.07), and a lack of regular exercise (OR: 2.00, 95% CI: 1.29-3.08). Similarly, independent determinants of a decreased d/a (lowest quartile of the d/a) were age (OR: 1.11 per 1-year increase, 95% CI: 1.08-1.14), hypertension (OR: 3.44, 95% CI: 2.20-5.38), and alcohol intake 6 or 7 days per week (OR: 2.70, 95% CI: 1.80-4.06). No independent association was observed between the SDPTG indices and blood leukocyte count or serum C-reactive protein levels. In conclusion, the SDPTG indices reflect arterial properties affected by several cardiovascular risk factors in middle-aged Japanese men. The association between inflammation and the SDPTG should be evaluated in further studies. 相似文献
7.
Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits 总被引:1,自引:1,他引:0
Atsunori Kamiya Toru Kawada Kenta Yamamoto Daisaku Michikami Hideto Ariumi Kazunori Uemura Can Zheng Syuji Shimizu Takeshi Aiba Tadayoshi Miyamoto Masaru Sugimachi Kenji Sunagawa 《The Journal of physiology》2005,566(1):237-246
Since humans are under ceaseless orthostatic stress, the mechanism to maintain arterial pressure (AP) under orthostatic stress against gravitational fluid shift is of great importance. We hypothesized that (1) orthostatic stress resets the arterial baroreflex control of sympathetic nerve activity (SNA) to a higher SNA, and (2) resetting of the arterial baroreflex contributes to preventing postural hypotension. Renal SNA and AP were recorded in eight anaesthetized, vagotomized and aortic-denervated rabbits. Isolated intracarotid sinus pressure (CSP) was increased stepwise from 40 to 160 mmHg with increments of 20 mmHg (60 s for each CSP level) while the animal was placed supine and at 60 deg upright tilt. Upright tilt shifted the CSP–SNA relationship (the baroreflex neural arc) to a higher SNA, shifted the SNA–AP relationship (the baroreflex peripheral arc) to a lower AP, and consequently moved the operating point to marked high SNA while maintaining AP. A simulation study suggests that resetting in the neural arc would double the orthostatic activation of SNA and increase the operating AP in upright tilt by 10 mmHg, compared with the absence of resetting. In addition, upright tilt did not change the CSP–AP relationship (the baroreflex total arc). A simulation study suggests that although a downward shift of the peripheral arc could shift the total arc downward, resetting in the neural arc would compensate this fall and prevent the total arc from shifting downward to a lower AP. In conclusion, upright tilt increases SNA by resetting the baroreflex neural arc. This resetting may compensate for the reduced pressor responses to SNA in the peripheral cardiovascular system and contribute to preventing postural hypotension. 相似文献
8.
Yoshinori Itoh Yutaka Kohgo Naoki Watanabe Yuji Kanisawa Sumio Sakamaki Minoru Takahashi Yasuo Hirayama Hiroyuki Ono Takeshi Himeno Yoshiro Niitsu 《Cancer science》1991,82(11):1203-1206
Human tumor–infiltrating lymphocytes (TILs) derived from pleural or ascitic fluid were incubated with recombinant interleukin 2 and transfected with human tumor necrosis factor (TNF) a gene by the lipofection procedure. The resulting TILs secreted significant amounts of TNF in the culture supernatant and exhibited cytotoxicity against established cell lines, such as K562 and Daudi, and autologous tumor cells. The TNF gene–transfected TILs exhibited an augmented killing of autologous tumor cells. 相似文献
9.
Histamine-type 2 antagonists (H2-blockers) as represented by cimentidine have been shown to adversely affect renal allograft function, particularly when coadministered
with cyclosporine, currently a major immunosuppressant. To determine whether or not a newer and more powerful H2-blocker, famotidine, would produce similar adverse effects, we assessed seven cyclosporine-treated renal allograft recipients
with regard to changes in their renal function on or off the H2-blocker over a one-week period. Neither the administration nor withdrawal of famotidine (20–40 mg/day) resulted in any significant
changes in serum creatine, BUN, urine output or cyclosporine trough levels, suggesting that famotidine can be safely administered
as an H2-blocker to cyclosporine-treated renal allograft recipients. 相似文献
10.
M Arai H Kawada T Kaburagi N Sakai Y Kudou M Kawakami K Konno T Takizawa 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(11):1457-1463
A 40-year-old man who lived in a wooden house built 30 years ago presented with complaints of fever, dry cough and dyspnea. Chest X-ray findings showed interstitial shadows throughout bilateral lung fields. After admission, high-dose administration of 3000 mg of methylprednisolone was performed because of deterioration of chest X-ray shadows and symptoms. In a week, clinical data and symptoms improved. Findings of BAL fluid on admission revealed a relative increase of lymphocytes, neutrophils and mast cells, and pathological findings of transbronchial lung biopsy revealed non-caseous granulation and alveolitis. Precipitating antibodies and indirect fluorescent antibodies against Trichosporon cutaneum and Cryptococcus neoformans had positive reactions and T. cutaneum was isolated and identified from the patient's house. A diagnosis of summer-type hypersensitivity pneumonitis was made according to the criteria advocated by Ando et al. This seemed to be a rare case of summer-type hypersensitivity pneumonitis prolonged after isolation from his normal living environment, successfully treated by high-dose administration of steroid. 相似文献