全文获取类型
收费全文 | 890篇 |
免费 | 31篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 13篇 |
妇产科学 | 12篇 |
基础医学 | 93篇 |
口腔科学 | 5篇 |
临床医学 | 45篇 |
内科学 | 233篇 |
皮肤病学 | 18篇 |
神经病学 | 20篇 |
特种医学 | 16篇 |
外国民族医学 | 1篇 |
外科学 | 214篇 |
综合类 | 20篇 |
预防医学 | 37篇 |
眼科学 | 12篇 |
药学 | 71篇 |
中国医学 | 5篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 13篇 |
2022年 | 12篇 |
2021年 | 48篇 |
2020年 | 24篇 |
2019年 | 16篇 |
2018年 | 33篇 |
2017年 | 17篇 |
2016年 | 21篇 |
2015年 | 20篇 |
2014年 | 30篇 |
2013年 | 37篇 |
2012年 | 58篇 |
2011年 | 59篇 |
2010年 | 41篇 |
2009年 | 36篇 |
2008年 | 64篇 |
2007年 | 57篇 |
2006年 | 62篇 |
2005年 | 57篇 |
2004年 | 40篇 |
2003年 | 43篇 |
2002年 | 38篇 |
2001年 | 10篇 |
2000年 | 9篇 |
1999年 | 9篇 |
1998年 | 3篇 |
1997年 | 7篇 |
1996年 | 2篇 |
1995年 | 6篇 |
1994年 | 2篇 |
1993年 | 7篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1960年 | 2篇 |
1947年 | 1篇 |
1942年 | 1篇 |
1941年 | 1篇 |
1940年 | 1篇 |
1938年 | 1篇 |
1937年 | 1篇 |
1936年 | 1篇 |
1930年 | 2篇 |
1929年 | 1篇 |
排序方式: 共有925条查询结果,搜索用时 15 毫秒
1.
Subodh Varshney Sandesh Sharma Viniyendra Pamecha Ajit Sewkani Lalish Jhawar Vinod Narkhede Virendra Tewari Kailash Patel 《Indian journal of gastroenterology》2003,22(3):91-93
INTRODUCTION: Radiofrequency (RF) tissue ablation has been tried safely and effectively in the West as percutaneous local tissue ablation therapy. We present our experience with this technique in malignant lesions. METHODS: RF tumor ablation was done using an RF generator (Berchtold; Germany) generating 35-50 RF watts of power output. The RF needle was placed in the tumor under image guidance (n = 22) or at open surgery (n = 1). Around 1500 watts/cm3 RF energy was delivered to the tumor. Over 21 months, 23 patients underwent the procedure for 73 lesions, including metastatic liver lesions (n = 21) and locally advanced inoperable carcinoma of pancreas (n = 2). RESULTS: All lesions less than 3 cm in size (n = 15) and 39% of lesions 3-4 cm in size (17/44) had complete necrosis. Residual tumor was seen in 27/44 lesions (61%) 3-4 cm in size and in all 14 lesions more than 4 cm in size. There was no mortality or major morbidity. There were two minor complications (ascites 1, pleural effusion 1). Of 21 patients treated for liver metastases, 10 are still alive (6-month survival 19/21 [90%] and 12-month survival 11/17 [64.7%]). Only 2 of 32 (6.2%) lesions with complete necrosis had local recurrence. CONCLUSION: RF tumor ablation is a safe and effective local tissue ablative method in Indian patients. 相似文献
2.
Immune responses induced by two dose strengths of an yeast-derived recombinant hepatitis B vaccine in adolescents. 总被引:2,自引:0,他引:2
3.
Nitin Gupta Saurabh Varshney S. S. Bist Pratima Gupta Rajat Bhatia 《Indian journal of otolaryngology and head and neck surgery》2007,59(4):309-312
Retropharyngeal abscesses were fairly common in preantibiotic era but the advent of antibiotics has reduced the overall incidence
of these abscesses. They still continue to occur specially in developing world and carry significant morbidity and even mortality
if not managed properly. The prevalence of this abscess in the young children pose a bigger challenge, as the examination
of oral cavity is difficult. Emphasis is placed on the age, sex, type, and duration of symptoms, bacteriology, methodology
of diagnosis, therapy and complications. With proper antibiotic cover and surgical management, majority of patients today
survive without major residual squeal. Hereby we present a series of 15 cases of retropharyngeal abscess. 相似文献
4.
Saurabh Varshney Jasprit Singh R. K. Saxena Anoop Kaushal V. P. Pathak 《Indian journal of otolaryngology and head and neck surgery》2004,56(1):54-56
A 55 years male presented with hoarsness of voice (4 months), cough (1 month), difficulty in breathing (15 days). Patient
underwent an emergency tracneostomy and further workup proved it to be a case of verrucous carcinoma of larynx. Patient was
treated surgically with satisfactory result. 相似文献
5.
6.
Deregulation of apoptosis is involved in prostate cancer development and progression. This study involved an immunohistochemical "profiling" of prostate tissue specimens from patients who underwent prostatectomy for localized prostate cancer, to identify apoptosis-specific alterations associated with premalignant precursor lesions. Prostate tissue was pathologically evaluated, and areas of benign acini, high-grade prostate intraepithelial neoplasia (HGPIN), and prostate cancer were identified. Immunohistochemical analysis was performed to determine the expression of p27Kip1, a key cell cycle regulator, transforming growth factor (TGF)-beta receptor II (TbetaRII), a critical signaling effector of TGF-beta; Smad4, a downstream intracellular effector of TGF-beta signaling; p53, a key apoptosis regulator; and prostate-specific antigen (PSA), a clinical marker of prostate cancer. The apoptotic index of the same cell populations was determined using the transferase-mediated digoxigenin-tagged 16-desoxy-uridine-triphosphate nick end labeling assay. Our findings indicate a significant reduction in p27Kip1 immunoreactivity in HGPIN (P<0.0001) and prostate cancer (P<0.0001) compared with the benign tissue. A significant down-regulation was detected in TbetaRII expression in HGPIN and prostate cancer compared with benign prostatic hyperplasia (BPH)(P<0.001). A significant decrease was also observed in Smad4 levels in HGPIN and prostate cancer compared with BPH (P<0.001). Evaluation of the incidence of apoptosis revealed a significant decrease in the apoptotic index among the epithelial cell populations in HGPIN and a further decrease in prostate carcinoma (P<0.01). This reduced apoptotic index correlated with a significant increase in p53 immunoreactivity in the prostatic carcinoma foci. Prostate cancer cells exhibited strong nuclear staining for p53 compared with adjacent HGPIN (P<0.05) and the benign lesions of the same prostate specimens (P<0.05). A significant reduction in PSA immunostaining was detected in HGPIN and prostate carcinoma foci compared with the benign glandular epithelia (P<0.001). These results further define deregulation of TGF-beta signaling effectors as a molecular basis for loss of apoptotic control contributing to the development of prostate tumors. Identification of apoptotic regulators in precursor premalignant lesions may have prognostic significance in disease progression as well as therapeutic value for targeting prostate cancer. 相似文献
7.
Swartz MJ Batra SK Varshney GC Hollingsworth MA Yeo CJ Cameron JL Wilentz RE Hruban RH Argani P 《American journal of clinical pathology》2002,117(5):791-796
Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the colon. The apomucin MUC4 has been implicated in invasive pancreatic adenocarcinoma. MUC4 expression is not detectable at the RNA level in normal pancreas but is detectable at high levels in invasive pancreatic adenocarcinoma. We documented the pattern of expression of MUC4 in PanINs by studying a series of 71 PanIN lesions immunohistochemically using a new monoclonal antibody to MUC4. Five (17%) of 30 PanIN-1 lesions, 10 (36%) of 28 PanIN-2 lesions, 11 (85%) of 13 PanIN-3 lesions, and 25 (89%) of 28 invasive adenocarcinomas labeled with the MUC4 antibody used in the study. In addition, afew nonneoplastic lesions labeled with the MUC4 antibody, including reactive ducts in chronic pancreatitis, atrophic ducts filled with inspissated secretions, and ducts showing squamous metaplasia. Our data help establish the patterns of MUC4 expression in neoplastic precursors in the pancreas and add further support to the progression model for pancreatic adenocarcinoma. 相似文献
8.
The validity domain of a modified Born approximation (MBA) has been examined for the scattering of a pulsed plane wave (PPW). This new approximation has been compared with exact results and also with the conventional Born approximation (BA). Comparisons have been made for the scattering by a homogeneous sphere. Error charts have been presented for various scatterer sizes and acoustic properties for forward as well as back scattering. The pulse width has also been varied. Our study shows that the modified Born approximation is generally preferable to the conventional Born approximation in the forward direction. In the backward direction both approximations have a similar kind of validity domain. These observations are important in view of the fact that the Born approximation has been widely used in acoustic scattering problems. 相似文献
9.
10.
The adsorption of carbofuran on sandy clay loam and silt loam soils has been studied at 30 and 50 degrees C. Adsorption data for both soils are in close agreement with the Freundlich isotherms and yield "S" class isotherms. The order of adsorption of carbofuran is in accordance with the partial molal free energy changes and conforms to the mobility of carbofuran in different soils. The thermodynamic constant (K0) and standard free energy (delta G degrees), enthalpy (delta H degrees), and entropy changes (delta S degrees) have also been calculated for predicting the nature of adsorption. 相似文献