全文获取类型
收费全文 | 295篇 |
免费 | 18篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 23篇 |
妇产科学 | 1篇 |
基础医学 | 21篇 |
口腔科学 | 4篇 |
临床医学 | 13篇 |
内科学 | 41篇 |
皮肤病学 | 9篇 |
神经病学 | 5篇 |
特种医学 | 27篇 |
外科学 | 22篇 |
综合类 | 12篇 |
预防医学 | 6篇 |
眼科学 | 120篇 |
药学 | 6篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 6篇 |
2020年 | 4篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 4篇 |
2016年 | 1篇 |
2015年 | 5篇 |
2014年 | 7篇 |
2013年 | 10篇 |
2012年 | 9篇 |
2011年 | 8篇 |
2010年 | 14篇 |
2009年 | 9篇 |
2008年 | 8篇 |
2007年 | 13篇 |
2006年 | 7篇 |
2005年 | 11篇 |
2004年 | 12篇 |
2003年 | 19篇 |
2002年 | 8篇 |
2001年 | 8篇 |
2000年 | 4篇 |
1999年 | 10篇 |
1998年 | 14篇 |
1997年 | 21篇 |
1996年 | 15篇 |
1995年 | 6篇 |
1994年 | 11篇 |
1993年 | 12篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 7篇 |
1989年 | 6篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1975年 | 2篇 |
排序方式: 共有322条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
Ignatius KP CHENG 《Nephrology (Carlton, Vic.)》1997,3(1):109-111
Summary: The involvement of the IgA immune system and complement components in IgA glomerulonephritis (IgAGN) has prompted the use of immunosuppressive drugs in therapy, but none has so far been shown to alter the natural course of the disease. Because most patients with IgAGN present during the chronic phase of their illness, at the time when the initiating immune events may no longer be active, nonimmune therapy which targets the common pathway of progressive renal injury is likely to be more useful. There is increasing evidence that angiotensin-converting enzyme inhibitors (ACEI) reduce proteinuria and renal injury in patients with IgAGN, and this effect may be observed in both normotensive and hypertensive patients. Yet to be determined is whether this effect is specific for ACEI and whatever other effective antihypertensive drugs may achieve a similar result. Fish oil has recently been shown to retard the progression of renal failure in patients with aggressive IgAGN, but a narrow therapeutic window appears to exist for this form of treatment. Antiplatelet agents on their own appear to be ineffective but in combination with anticoagulation (low dose warfarin) have been shown to have an antiproteinuric effect and may preserve renal function in patients with progressive disease. Future directions of non-immune therapy of IgAGN include evaluation of the renoprotective effect of angiotensin II receptor antagonists, free-radical scavengers and antilipid drugs. More work should also be done to identify factors which put the patients at risk of developing progressive disease and which predict therapeutic response, as has been done recently with the identification of the deletion polymorphism of the angiotensin-converting enzyme gene as a marker of progressive disease and therapeutic response to ACEI in patients with IgAGN. 相似文献
7.
After a slow-release pilocarpine carrier had been applied for three months, the conjunctival epithelium of two Cynomolgus monkeys showed some remarkable changes in the structure and distribution of the cell types as defined by the authors. The goblet cells (Type I) had almost entirely disappeared, whereas the epithelial cells with secretion granules (Type II) had considerably increased in number. The morphology of the Type II cells gave clear indications of a very active metabolism. In a control experiment, in which two Cynomolgus monkeys treated with a 4% pilocarpine solution for three months, these ultrastructural changes did not occur; it must therefore be assumed that mechanical irritation of the conjunctiva was the cause. 相似文献
8.
M Zierhut H J Thiel E G Weidle K P Steuhl K S?nnichsen C Müller H Hübner 《Klinische Monatsbl?tter für Augenheilkunde》1988,192(4):340-347
Chronic blister-forming dermatosis can lead to conjunctival and corneal involvement. Taking one such case as an example, the authors show that while disorders of this kind can be classified as a form of bullous dermatosis, the differential diagnostic classification is not unequivocal, regardless of the examination method adopted. The term "overlay syndrome" has been introduced into the dermatologic literature to cover clinical pictures of this kind. 相似文献
9.
10.
Myosin VIIA gene: heterogeneity of the mutations responsible for Usher syndrome type IB 总被引:8,自引:1,他引:8
Levy G; Levi-Acobas F; Blanchard S; Gerber S; Larget-Piet D; Chenal V; Liu XZ; Newton V; Steel KP; Brown SD; Munnich A; Kaplan J; Petit C; Weil D 《Human molecular genetics》1997,6(1):111-116
Usher syndrome is recognized as the most frequent cause of hereditary
deaf-blindness. Usher syndrome type I (USH1), the most severe form of the
disease, is characterized by profound congenital sensorineural deafness,
constant vestibular dysfunction, and retinitis pigmentosa of prepubertal
onset. This form is genetically heterogeneous and five loci (USH1A-E) have
been mapped thusfar. However, only the gene responsible for USH1 B (which
accounts for approximately 75% of USH1 cases) has been characterized. It
encodes a long-tailed unconventional myosin, myosin VIIA, with a predicted
2215 amino acid sequence. Primers covering the complete myosin VIIA coding
sequence as well as the 3' non coding sequence were designed, allowing
direct sequence analysis of each of the 48 coding exons and flanking splice
sites in seven patients affected by USH1. Four novel mutations were thereby
identified. The possibility should now be considered of a sequence-based
prenatal diagnosis in some of the families affected by this very severe
form of Usher syndrome.
相似文献