全文获取类型
收费全文 | 23033篇 |
免费 | 1574篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 384篇 |
儿科学 | 686篇 |
妇产科学 | 413篇 |
基础医学 | 3261篇 |
口腔科学 | 356篇 |
临床医学 | 2206篇 |
内科学 | 4708篇 |
皮肤病学 | 893篇 |
神经病学 | 2358篇 |
特种医学 | 865篇 |
外国民族医学 | 2篇 |
外科学 | 3476篇 |
综合类 | 215篇 |
一般理论 | 5篇 |
预防医学 | 1608篇 |
眼科学 | 368篇 |
药学 | 1454篇 |
中国医学 | 34篇 |
肿瘤学 | 1362篇 |
出版年
2023年 | 114篇 |
2022年 | 115篇 |
2021年 | 328篇 |
2020年 | 212篇 |
2019年 | 280篇 |
2018年 | 624篇 |
2017年 | 428篇 |
2016年 | 541篇 |
2015年 | 593篇 |
2014年 | 585篇 |
2013年 | 930篇 |
2012年 | 1551篇 |
2011年 | 1588篇 |
2010年 | 763篇 |
2009年 | 623篇 |
2008年 | 1222篇 |
2007年 | 1333篇 |
2006年 | 1277篇 |
2005年 | 1202篇 |
2004年 | 1144篇 |
2003年 | 1044篇 |
2002年 | 1018篇 |
2001年 | 587篇 |
2000年 | 563篇 |
1999年 | 554篇 |
1998年 | 167篇 |
1997年 | 125篇 |
1996年 | 104篇 |
1995年 | 121篇 |
1994年 | 121篇 |
1993年 | 96篇 |
1992年 | 254篇 |
1991年 | 292篇 |
1990年 | 237篇 |
1989年 | 236篇 |
1988年 | 202篇 |
1987年 | 213篇 |
1986年 | 200篇 |
1985年 | 211篇 |
1984年 | 138篇 |
1983年 | 141篇 |
1981年 | 95篇 |
1979年 | 140篇 |
1978年 | 101篇 |
1977年 | 93篇 |
1975年 | 117篇 |
1974年 | 122篇 |
1973年 | 101篇 |
1972年 | 111篇 |
1971年 | 99篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Marta Rozanski Valentin Neuhaus Emily Thornton Stéphanie J. E. Becker James P. Rathmell David Ring 《Journal of hand and microsurgery》2015,7(1):30-35
This study used the National Survey of Ambulatory Surgery (NSAS) database to measure the incidence of and risk factors for symptoms in the ambulatory surgery center and problems within 24 h after isolated carpal tunnel release (CTR). The NSAS contained records on 400,000 adult patients with carpal tunnel syndrome who were treated with CTR in 2006, based on ICD-9 codes. The type of anesthesia used and factors associated with symptoms and problems were sought in bivariate and multivariable statistical analyses. The mean duration of the procedure was 16 ± 8.8 min. Only 5 % were performed under local anesthesia without sedation, 45 % with IV sedation, 28 % regional anesthesia, and 19 % general anesthesia. Symptoms in the ambulatory surgery center or a problem within 24 h after discharge were recorded in 10 % of patients, all of them minor and transient, including difficulties with pain and its treatment. The strongest risk factors were male sex, age of 45 years and older, and participation of an anesthesiologist. Local anesthesia and regional anesthesia were associated with more perioperative symptoms and postoperative problems. Most CTR are performed with some sedation in the United States. CTR is a safe procedure: one in 10 patients will experience a minor issue in the perioperative or immediate postoperative period. 相似文献
2.
3.
More than just crushing: a prospective pre‐post intervention study to reduce drug preparation errors in patients with feeding tubes 下载免费PDF全文
4.
5.
L. Misery E. Weisshaar E. Brenaut A.W.M. Evers F. Huet S. Ständer A. Reich E. Berardesca E. Serra-Baldrich J. Wallengren D. Linder J.W. Fluhr J.C. Szepietowski H. Maibach for the Special Interest Group on sensitive skin of the International Forum for the Study of Itch 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):222-229
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin – as well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin. 相似文献
6.
三维骨建模在全膝关节置换术中韧带平衡的作用 总被引:3,自引:3,他引:0
吴昊 《中国修复重建外科杂志》2006,20(6):607-610
目的探讨以三维骨建模为基础、无需影像的计算机辅助系统在人工全膝关节置换术(totalknee arthroplasty,TKA)中韧带平衡的作用。方法2002年11月~2003年6月,采用后稳定型人工全膝关节,在Ceravision无需影像资料的三维骨建模系统导航监控下,辅助完成TKA21例。男5例,女16例,年龄64~79岁,平均72.4岁。其中2例既往行胫骨近端截骨术,1例行股骨远端截骨术。14例膝内翻,7例膝外翻。术前下肢全长X线正位片测量,内翻13°~外翻13°,平均2.36°;膝关节X线正位片测量,应力下内翻平均8.47°(内翻2°~内翻20°),应力下外翻平均3.63°(内翻7°~外翻12°)。结果术中导航系统测量,额面内翻12°~外翻10°,平均3.33°,与术前比较差异有统计学意义(P<0.05);额面应力下内翻平均6.47°(内翻0°~内翻24°),应力下外翻平均4.32°(内翻8°~外翻15°),与术前比较差异有统计学意义(P<0.05)。术毕导航系统测得膝内外翻平均0.175°(内翻2°~外翻3°),而术后下肢全长X线正位片测量平均0.3°(内翻3.5°~外翻1.5°),二者差异无统计学意义(P>0.05)。术后3个月关节活动度为105~130°,平均115°,膝关节额面松弛度0.2~0.5cm,平均0.27cm。人工膝关节胫、股骨假体取得满意的对位置入和韧带平衡,无关节失稳和髌骨脱位等并发症发生。结论以三维骨建模为基础、无需影像的Ceravision系统,具有三维立体定位、优化截骨,并通过旋转对位和韧带松解获得伸屈膝关节等距间隙与韧带平衡稳定的作用,近期临床疗效满意,可在TKA中常规使用。 相似文献
7.
8.
Effect of unilateral ureteral occlusion on fibrin deposition in the kidney and renal blood flow during intravascular coagulation in rat 总被引:1,自引:0,他引:1
The effect of unilateral ureteral occlusion on fibrin deposition in the kidney and the interrelation of the fibrin deposition and the renal blood flow was studied in rat. Intravascular coagulation in the kidney was induced by infusion of thrombin and inhibition of fibrinolysis with tranexamic acid. The effects unilateral occlusion of the ureter for 1 and 24 h on fibrin deposition and renal blood flow were studied. Fibrin in the kidneys was quantitated by intravenous injection of 125I-labelled fibrinogen 24 h before the experiment. The renal blood flow was measured before and after infusion of thrombin by injection of 85Sr- and 141Ce-labelled microspheres into the left ventricle. After ureteral occlusion for 1 h the deposition of fibrin in the kidneys was unaffected. After 24 h substantially less fibrin deposition was found in the occluded than in the unoccluded kidney (0.3 +/- 0.2 and 5.7 +/- 1.6 mg, respectively; p less than 0.05). Before thrombin infusion the blood flow to the occluded kidney was less than that in the unoccluded kidney (2.1 +/- 0.8 and 3.7 +/- 1.2 ml/min, 100 g body weight, respectively; p less than 0.05). The blood flow after infusion of thrombin was equally reduced in both kidneys. The results contradict the hypothesis that vasoconstriction increases the amount of fibrin in the kidneys in thrombin-induced intravascular coagulation. 相似文献
9.
G Stüttgen 《Zeitschrift für Hautkrankheiten》1989,64(11):971-6, 979
We discuss the senescence of the skin considering both intrinsic aging and photoaging; special regard is paid to the various layers, the microcirculation, and the adnexa of the skin. In particular, the barrier function and microcirculation of the skin has been pointed out. 相似文献
10.
Pascale Jolliet Stéphane Nion Gwena?lle Allain-Veyrac L Tilloy-Fenart Dorothée Vanuxeem Vincent Berezowski Roméo Cecchelli 《Pharmacological research》2007,56(1):11-17
PURPOSE: The objective of the current study was to determine the ability of some antiemetic compounds to cross the blood-brain barrier (BBB) and thereby to determine possible side effects of compounds for the central nervous system (CNS). METHODS: We compared the brain penetration of some antiemetic compounds using an in vitro BBB model consisting in brain capillary endothelial cells co-cultured with primary rat glial cells. RESULTS: This study clearly demonstrated that the metopimazine metabolite, metopimazine acid, has a very low brain penetration, lower than metopimazine and even less than the other antiemetic compounds tested in this study. CONCLUSIONS: The poor brain penetration of metopimazine acid, metopimazine biodisponible form, seems very likely related to the clinically observed difference in therapeutic and safety profile. 相似文献