全文获取类型
收费全文 | 1236篇 |
免费 | 103篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 60篇 |
妇产科学 | 21篇 |
基础医学 | 170篇 |
口腔科学 | 37篇 |
临床医学 | 98篇 |
内科学 | 258篇 |
皮肤病学 | 20篇 |
神经病学 | 38篇 |
特种医学 | 25篇 |
外科学 | 196篇 |
综合类 | 18篇 |
预防医学 | 83篇 |
眼科学 | 52篇 |
药学 | 167篇 |
中国医学 | 4篇 |
肿瘤学 | 91篇 |
出版年
2024年 | 3篇 |
2023年 | 13篇 |
2022年 | 23篇 |
2021年 | 32篇 |
2020年 | 26篇 |
2019年 | 38篇 |
2018年 | 44篇 |
2017年 | 27篇 |
2016年 | 43篇 |
2015年 | 44篇 |
2014年 | 61篇 |
2013年 | 48篇 |
2012年 | 114篇 |
2011年 | 87篇 |
2010年 | 55篇 |
2009年 | 52篇 |
2008年 | 62篇 |
2007年 | 56篇 |
2006年 | 86篇 |
2005年 | 63篇 |
2004年 | 60篇 |
2003年 | 41篇 |
2002年 | 46篇 |
2001年 | 28篇 |
2000年 | 23篇 |
1999年 | 20篇 |
1998年 | 12篇 |
1996年 | 7篇 |
1995年 | 7篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 14篇 |
1991年 | 6篇 |
1990年 | 4篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 8篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1983年 | 5篇 |
1981年 | 12篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1972年 | 2篇 |
1966年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有1343条查询结果,搜索用时 0 毫秒
1.
Marie Warrer Petersen Tine Sylvest Meyhoff Marie Helleberg Maj-Brit Nørregaard Kjær Anders Granholm Carl Johan Steensen Hjortsø Thomas Steen Jensen Morten Hylander Møller Peter Buhl Hjortrup Mik Wetterslev Gitte Kingo Vesterlund Lene Russell Vibeke Lind Jørgensen Klaus Tjelle Thomas Benfield Charlotte Suppli Ulrik Anne Sofie Andreasen Thomas Mohr Morten H. Bestle Lone Musaeus Poulsen Mette Friberg Hitz Thomas Hildebrandt Lene Surland Knudsen Anders Møller Christoffer Grant Sølling Anne Craveiro Brøchner Bodil Steen Rasmussen Henrik Nielsen Steffen Christensen Thomas Strøm Maria Cronhjort Rebecka Rubenson Wahlin Stephan Jakob Luca Cioccari Balasubramanian Venkatesh Naomi Hammond Vivekanand Jha Sheila Nainan Myatra Christian Gluud Theis Lange Anders Perner 《Acta anaesthesiologica Scandinavica》2020,64(9):1365-1375
Introduction
Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.Methods
The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving ≥10 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.Discussion
The COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.2.
3.
Sendhil K Balasubramanian Ravindranath Tiruvoipati Mohammed Amin Kanakkande K Aabideen Giles J Peek Andrew W Sosnowski Richard K Firmin 《Journal of cardiothoracic surgery》2007,2(1):4-9
Background
Veno-arterial extracorporeal membrane oxygenation (ECMO) is a common modality of circulatory assist device used in children. We assessed the outcome of children who had ECMO following repair of congenital cardiac defects (CCD) and identified the risk factors associated with hospital mortality. 相似文献4.
5.
6.
Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai,Tamil Nadu,India
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kabilan L Balasubramanian S Keshava SM Thenmozhi V Sekar G Tewari SC Arunachalam N Rajendran R Satyanarayana K 《Journal of clinical microbiology》2003,41(8):3919-3921
An investigation in a referral pediatric hospital has indicated that during a recent dengue outbreak in Chennai, Tamil Nadu, India, dengue in infancy constituted 20% of total dengue virus infections with low mortality rates in this hospital. In developing countries, strengthening of dengue management capabilities at hospitals can prevent dengue-related deaths in infants. 相似文献
7.
Balasubramanian M Kini S Naik L Kirtikumar Deshpande J 《Indian journal of pathology & microbiology》2004,47(4):518-520
Angiodysplasia of gastrointestinal tract is still thought to be an entity of unknown aetiology. This lesion is most commonly observed in elderly patients presenting with severe and persistent iron deficiency anaemia, following occult blood loss or acute episodes of haematemesis. In the stomach antral vascular ectasia is the most common presentation. We report an autopsy case of vascular ectasia in the cardia of stomach in a young patient with clinical symptoms of anaemia as the presentation and an associated secondary hemosiderosis of liver. 相似文献
8.
Development and characterization of a whole-cell radioligand binding assay for [125I]gp120 of HIV-1.
L P To V Balasubramanian M E Charlton T A Francis C Doyle P M Sweetnam 《Journal of immunoassay》1992,13(1):61-83
The binding of HIV-1 envelope glycoprotein, gp120, to the CD4 receptor is an important step in productive infection. The development of agents which interrupt this binding phenomenon should be of therapeutic interest. The present study characterizes a whole cell gp120/CD4 radioligand binding assay (radioligand binding assay) modified for use in a high volume screening format. Modifications include the use of human CD4 receptor stably expressed in a Chinese hamster ovary cell line and the gentle fixation (paraformaldehyde) of the CD4 receptor just prior to assay. Binding of [125I]gp120 to fixed CD4 was of high affinity (KD = 6 nM), saturable, reversible, and specific. The kinetics of binding were identical to those of viable (non-fixed) CD4 receptor. [125I]gp120 binding was inhibited by unlabeled recombinant gp120, soluble CD4, and the anti-CD4 monoclonals OKT4A and LEU3A. A number of compounds reported to inhibit gp120 binding and/or gp120 induced syncytium formation were also active in this assay. This modified radioligand binding assay was developed to initiate a rational and extensive screening program to assist in the identification of potential chemotherapeutic agents based on their ability to inhibit gp120 binding to host cells. 相似文献
9.
Extracorporeal membrane oxygenation with lepirudin anticoagulation for Wegener's granulomatosis with heparin-induced thrombocytopenia 总被引:1,自引:0,他引:1
Balasubramanian SK Tiruvoipati R Chatterjee S Sosnowski A Firmin RK 《ASAIO journal (American Society for Artificial Internal Organs : 1992)》2005,51(4):477-479
Venovenous extracorporeal membrane oxygenation with lepirudin anticoagulation was successfully used for a complicated case of Wegener's granulomatosis and heparin-induced thrombocytopenia. Interestingly, a linear correlation was found between activated partial thromboplastin time and activated clotting time during lepirudin anticoagulation. 相似文献