全文获取类型
收费全文 | 1950篇 |
免费 | 158篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 49篇 |
妇产科学 | 52篇 |
基础医学 | 258篇 |
口腔科学 | 141篇 |
临床医学 | 171篇 |
内科学 | 399篇 |
皮肤病学 | 22篇 |
神经病学 | 179篇 |
特种医学 | 88篇 |
外科学 | 237篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 131篇 |
眼科学 | 50篇 |
药学 | 149篇 |
中国医学 | 9篇 |
肿瘤学 | 124篇 |
出版年
2024年 | 2篇 |
2023年 | 24篇 |
2022年 | 44篇 |
2021年 | 77篇 |
2020年 | 68篇 |
2019年 | 80篇 |
2018年 | 87篇 |
2017年 | 51篇 |
2016年 | 90篇 |
2015年 | 72篇 |
2014年 | 101篇 |
2013年 | 114篇 |
2012年 | 168篇 |
2011年 | 157篇 |
2010年 | 76篇 |
2009年 | 76篇 |
2008年 | 127篇 |
2007年 | 125篇 |
2006年 | 90篇 |
2005年 | 68篇 |
2004年 | 76篇 |
2003年 | 81篇 |
2002年 | 54篇 |
2001年 | 23篇 |
2000年 | 26篇 |
1999年 | 20篇 |
1998年 | 12篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1994年 | 9篇 |
1992年 | 3篇 |
1991年 | 7篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1973年 | 2篇 |
1971年 | 3篇 |
1968年 | 3篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有2115条查询结果,搜索用时 15 毫秒
1.
2.
Mariela Dutra Gontijo Moura Soraya de Mattos Camargo Grossmann Linaena Méricy da Silva Fonseca Maria Inês Barreiros Senna Ricardo Alves Mesquita 《Journal of oral pathology & medicine》2006,35(6):321-326
BACKGROUND: Oral hairy leukoplakia (OHL) may be an indicator of the progression of Human Immunodeficiency Virus (HIV)-induced immuno-depression, and the evaluation of risk factors leading to OHL is important in the management of these HIV-infected patients. However, there are few studies that analyze risk factors leading to OHL in the Brazilian population. The aim of this case-control study is to present data about prevalence rates and risk factors leading to OHL in a sample of HIV-infected adults in Brazil. METHODS: This case-control study included 111 HIV-infected patients treated at a clinic for sexually transmitted diseases and HIV. In the initial examinations with dentists, variables were collected from all patients. Diagnosis of OHL was performed in accordance with the International Classification System and cytological features. The Fisher and the chi-squared tests were used for statistical analysis. The proportional prevalence and odds ratio were estimated. RESULTS: Outcome presented a positive, statistically significant association among the presence of OHL and viral load of 3000 copies/mul or greater (P = 0.0001; odds ratio (OR) = 5.8), presence of oral candidiasis (P = 0.0000; OR = 11.1), previous use of fluconazole (P = 0.0000; OR = 24.6), and use of systemic acyclovir (P = 0.032; OR = 4.3). Antiretroviral medication presented a negative, statistically significant association with the presence of OHL (P = 0.002; OR = 8.4). CONCLUSIONS: Prevalence of OHL was 28.8%. Viral load, oral candidiasis, previous use of fluconazole, and systemic acyclovir were determined to be risk factors for OHL. Antiretroviral medication proved to be protective against the development of OHL. 相似文献
3.
4.
Charles Seydoux Danièle Gillard Berguer Eric Eeckhout Frank Stumpe Michel Hurni Patrick Ruchat Hossein Sadeghi Jean-Jacques Goy 《Transplant international》1996,9(4):433-436
Transplant atherosclerotic coronary disease remains the leading cause of death in heart transplant recipients. We report the first case of coronary stent implantation in a heart graft for epicardial focal stenosis. Due to the lower rate of restenosis after stenting in the native coronary artery, we suggest that coronary stenting be considered an acceptable, first intention therapeutic option instead of angioplasty alone whenever possible. 相似文献
5.
Rectal diazepam in the treatment of absence status: a pharmacodynamic study 总被引:7,自引:1,他引:6
下载免费PDF全文
![点击此处可从《Journal of neurology, neurosurgery, and psychiatry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Norman Milligan Soraya Dhillon Alan Richens Jolyon Oxley 《Journal of neurology, neurosurgery, and psychiatry》1981,44(10):914-917
Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG. Pharmacokinetic studies indicate that diazepam can have antiepileptic properties at serum levels well below those previously reported as being necessary to achieve a therapeutic effect. 相似文献
6.
7.
An attempt was made to investigate the proliferative effect of interleukin-7 (IL-7) on a rat Nb2 T-cell lymphoma line. It was demonstrated that both human and mouse IL-7 stimulated these cells to proliferate in a dose dependent fashion in culture medium containing 10% horse serum. The maximum activities of mIL-7 and hIL-7 were observed at 100 and 1000 units/ml with their half-maximal response of 10 and 50 units/ml, respectively. In a totally serum-free culture condition, mIL-7 produced a similar cellular proliferation, whereas hIL-7 was much less effective. The effectiveness of IL-7 on Nb2 cells was completely abolished by antibody to IL-7, but not by antibody to IL-2. Therefore, Nb2 cells may serve as a simple, convenient and sensitive assay for monitoring the biological activity of IL-7 in vitro. In addition, these cells are also useful for studying the lymphopoiesis of T-cell lineage regulated by IL-7. 相似文献
8.
The present study was aimed at evaluating the acute effects of Calcium-Magnesium soft gels (CalMag) in morphine tolerant and dependent mice. Mice were rendered tolerant and dependent on morphine by subcutaneous injection of morphine over a fixed time period. Withdrawal signs were precipitated by injecting naloxone 2 h after the final injection of morphine. The tail-pinch assay was used to investigate the effects of various compounds on the development and reversal of morphine tolerance. Acute injection of CalMag (containing 50 mg/kg calcium and 25 mg/kg magnesium) significantly reduced the number of jumps, stands and fast breathing in morphine dependent mice. Co-administration of calcium (50 mg/kg) and magnesium (25 mg/kg) was also effective in preventing the development of morphine tolerance and dependence. Administration of calcium (up to 50 mg/kg) alone did not significantly block the development of tolerance and dependence. The mean latency to pain was significantly increased in animals pretreated with CalMag (containing 50 mg/kg calcium and 25 mg/kg magnesium). The mixture of calcium and magnesium at specific concentrations seem to be critical for preventing the development of morphine tolerance and dependence. 相似文献
9.
10.