全文获取类型
| 收费全文 | 13599篇 |
| 免费 | 1189篇 |
| 国内免费 | 47篇 |
专业分类
| 耳鼻咽喉 | 90篇 |
| 儿科学 | 404篇 |
| 妇产科学 | 342篇 |
| 基础医学 | 2232篇 |
| 口腔科学 | 106篇 |
| 临床医学 | 1421篇 |
| 内科学 | 2941篇 |
| 皮肤病学 | 290篇 |
| 神经病学 | 1426篇 |
| 特种医学 | 396篇 |
| 外科学 | 1669篇 |
| 综合类 | 56篇 |
| 现状与发展 | 1篇 |
| 一般理论 | 7篇 |
| 预防医学 | 1071篇 |
| 眼科学 | 233篇 |
| 药学 | 867篇 |
| 中国医学 | 16篇 |
| 肿瘤学 | 1267篇 |
出版年
| 2024年 | 17篇 |
| 2023年 | 146篇 |
| 2022年 | 256篇 |
| 2021年 | 545篇 |
| 2020年 | 353篇 |
| 2019年 | 507篇 |
| 2018年 | 505篇 |
| 2017年 | 387篇 |
| 2016年 | 402篇 |
| 2015年 | 448篇 |
| 2014年 | 607篇 |
| 2013年 | 702篇 |
| 2012年 | 1104篇 |
| 2011年 | 1062篇 |
| 2010年 | 586篇 |
| 2009年 | 442篇 |
| 2008年 | 812篇 |
| 2007年 | 808篇 |
| 2006年 | 729篇 |
| 2005年 | 752篇 |
| 2004年 | 652篇 |
| 2003年 | 593篇 |
| 2002年 | 540篇 |
| 2001年 | 152篇 |
| 2000年 | 140篇 |
| 1999年 | 164篇 |
| 1998年 | 135篇 |
| 1997年 | 94篇 |
| 1996年 | 74篇 |
| 1995年 | 65篇 |
| 1994年 | 53篇 |
| 1993年 | 44篇 |
| 1992年 | 105篇 |
| 1991年 | 86篇 |
| 1990年 | 74篇 |
| 1989年 | 82篇 |
| 1988年 | 71篇 |
| 1987年 | 63篇 |
| 1986年 | 62篇 |
| 1985年 | 68篇 |
| 1984年 | 33篇 |
| 1983年 | 31篇 |
| 1982年 | 18篇 |
| 1981年 | 22篇 |
| 1979年 | 21篇 |
| 1977年 | 23篇 |
| 1976年 | 16篇 |
| 1973年 | 17篇 |
| 1972年 | 15篇 |
| 1969年 | 17篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
1.
2.
3.
4.
Sex chromosome trisomies (SCT) are among the most common chromosomal duplications in humans. Due to recent technological advances in non-invasive screening, SCT can already be detected during pregnancy. This calls for more knowledge about the development of (young) children with SCT. This review focused on neurocognitive functioning of children with SCT between 0 and 18 years, on domains of global intellectual functioning, language, executive functioning, and social cognition, in order to identify targets that could benefit from early treatment. Online databases were used to identify peer-reviewed scientific articles using specific search terms. In total 18 studies were included. When applicable, effect sizes were calculated to indicate clinical significance. Results of the reviewed studies show that although traditionally, the focus has been on language and intelligence (IQ) in this population, recent studies suggest that executive functioning and social cognition may also be significantly affected already in childhood. These findings suggest that neuropsychological screening of children diagnosed with SCT should be extended, to also include executive functioning and social cognition. Knowledge about these neurocognitive risks is important to improve clinical care and help identify targets for early support and intervention programs to accommodate for the needs of individuals with SCT. 相似文献
5.
B. Midouni E. Mehiri A. Ghariani H. Draoui L. Essalah I. Bouzouita D. Raoult L. Slim-Saidi P.E. Fournier 《International journal of antimicrobial agents》2019,53(1):63-69
Objectives
This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital.Methods
A total of 141 S. pneumoniae strains isolated between 2009–2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility testing was performed the disk diffusion method. MICs of penicillin G, amoxicillin and cefotaxime were determined by Etest. Serotyping was inferred from the results of multiplex PCR targeting 40 serotypes. Sequence types (STs) were determined by multilocus sequence typing (MLST).Results
Among the 141 S. pneumoniae isolates, 98 (69.5%) were resistant to erythromycin. Evaluation of β-lactam susceptibility showed that 90 strains (63.8%) were non-susceptible to penicillin, whereas 48 (34.0%) had decreased susceptibility to amoxicillin and 21 (14.9%) to cefotaxime. Twenty-five serotypes were detected, and 10 isolates were classified as non-typeable. Vaccine coverage was 56.7%, 60.3% and 75.2% for pneumococcal conjugate vaccine 7 (PCV7), PCV10 and PCV13, respectively. Overall, 73 STs were identified, including 23 described for the first time. The most frequent STs were ST179 (n?=?17), ST3772 (n?=?14), ST2918 (n?=?10) and ST4003 (n?=?5), related to serotypes 19F, 19A, 14 and 23F, respectively. Moreover, 110 strains were classified within 45 STs. Three international antimicrobial-resistant clones were found, including Denmark14-ST230 (n?=?22), Spain9V-ST156 (n?=?22) and Portugal19F-ST177 (n?=?20).Conclusion
This study emphasises the clonal and international dissemination of antimicrobial-resistant S. pneumoniae clones. Significant differences in genetic variation were documented by MLST within the various serotypes identified. 相似文献6.
7.
Hanna Lee Mary K. Tan Andrew T. Yan Paul Angaran Paul Dorian Claudia Bucci Jean C. Gregoire Alan D. Bell Martin S. Green Peter L. Gross Allan Skanes Charles R. Kerr L. Brent Mitchell Jafna L. Cox Vidal Essebag Brett Heilbron Krishnan Ramanathan Carl Fournier Shaun G. Goodman 《The Canadian journal of cardiology》2019,35(2):160-168
Background
Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain.Methods
We pooled data from 2 national primary care physician chart audit databases of patients with AF (Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation and Coordinated National Network to Engage Physicians in the Care and Treatment of Patients with Atrial Fibrillation Chart Audit) with a combined 1035 physicians (133 female, 902 male) and 10,927 patients (4567 female and 6360 male).Results
Male physicians underestimated stroke risk in female patients and overestimated risk in male patients. Female physicians estimated stroke risk well in female patients but underestimated the risk in male patients. Risk of bleeding was underestimated in all. Despite differences in risk assessment by physician and patient sex, > 90% of patients received anticoagulation across all subgroups. There was modest agreement between physician estimated and calculated (ie, CHADS2 score) stroke risk: Kappa scores were 0.41 (0.35-0.47) for female physicians and 0.34 (0.32-0.36) for male physicians.Conclusions
Our study is the first to examine the association between patient and physician sex influences and stroke and bleeding risk estimation in AF. Although there were differences in agreement between physician estimated stroke risk and calculated CHADS2 scores, these differences were small and unlikely to affect clinical practice; further, despite any perceived differences in the accuracy of risk assessment by sex, most patients received anticoagulation. 相似文献8.
Xiaoxuan Liu Ameenat L. Solebo Livia Faes Sophie Beese Tasanee Braithwaite Matthew E. Round 《Ocular immunology and inflammation》2020,28(6):898-907
ABSTRACT
Purpose
New instrument-based techniques for anterior chamber (AC) cell counting can offer automation and objectivity above clinician assessment. This review aims to identify such instruments and its correlation with clinician estimates. 相似文献9.
10.
Renaud Snanoudj Nassim Kamar Elisabeth Cassuto Sophie Caillard Marie Metzger Pierre Merville Antoine Thierry Isabelle Jollet Philippe Grimbert Dany Anglicheau Marc Hazzan Gabriel Choukroun Bruno Hurault De Ligny Bénedicte Janbon Vincent Vuiblet Anne Devys Yann Le Meur Michel Delahousse Jean-Luc Taupin 《Kidney international》2019,95(6):1471-1485