全文获取类型
收费全文 | 286篇 |
免费 | 51篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 22篇 |
妇产科学 | 3篇 |
基础医学 | 43篇 |
口腔科学 | 8篇 |
临床医学 | 35篇 |
内科学 | 74篇 |
皮肤病学 | 25篇 |
神经病学 | 12篇 |
特种医学 | 14篇 |
外科学 | 47篇 |
综合类 | 2篇 |
现状与发展 | 1篇 |
预防医学 | 14篇 |
眼科学 | 5篇 |
药学 | 14篇 |
肿瘤学 | 18篇 |
出版年
2024年 | 2篇 |
2023年 | 9篇 |
2022年 | 22篇 |
2021年 | 21篇 |
2020年 | 7篇 |
2019年 | 14篇 |
2018年 | 20篇 |
2017年 | 11篇 |
2016年 | 21篇 |
2015年 | 14篇 |
2014年 | 14篇 |
2013年 | 17篇 |
2012年 | 17篇 |
2011年 | 33篇 |
2010年 | 22篇 |
2009年 | 15篇 |
2008年 | 13篇 |
2007年 | 9篇 |
2006年 | 11篇 |
2005年 | 12篇 |
2004年 | 11篇 |
2003年 | 11篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1995年 | 1篇 |
1993年 | 2篇 |
1990年 | 1篇 |
排序方式: 共有338条查询结果,搜索用时 15 毫秒
1.
Self-contained underwater breathing apparatus (scuba) diving has grown in popularity, with nearly 9 million sport divers in
the United States alone. Approximately 7% of the population has been diagnosed with asthma, which is similar to the percentage
of divers admitting they have asthma. Numerous concerns exist regarding subjects with asthma who choose to participate in
recreational diving. Among these concerns are pulmonary barotrauma, pneumomediastinum, pneumothorax, arterial gas embolism,
ear barotrauma, sinus barotrauma, and dental barotrauma. Despite these concerns, a paucity of information exists linking asthma
to increased risk of diving complications. However, it has long been the norm to discourage individuals with asthma from participating
in recreational scuba diving. This article examines the currently available literature to allow for a more informed decision
regarding the possible risks associated with diving and asthma. It examines the underlying physiological principles associated
with diving, including Henry’s law and Boyle’s law, to provide a more intimate understanding on physiological changes occurring
in the respiratory system under compressive stress. Finally, this article offers a framework for guiding the patient with
asthma who is interested in scuba diving. Under the right circumstances, the patient with asthma can safely participate in
recreational diving without apparent increased risk of an asthma-related event. 相似文献
2.
Amin Sadeghi Dousari Seyed Soheil Hosseininasab Fatemeh Sadeghi Dousari Masoumeh Fuladvandi Naghmeh Satarzadeh 《World Journal of Virology》2023,12(2):91-99
The coronavirus disease 2019 (COVID-19) disease was first detected in December 2019 in Wuhan, China. This disease is currently one of the most important global health problems. The novel coronavirus COVID-19 is a respiratory illness, that has caused a deadly pandemic that is spreading rapidly around the world. It is not only a respiratory system virus that causes severe lung disease, but also a systemic disease agent that can affect all systems. People with COVID-19 disease usually have respiratory signs, however, the liver disorder is not an uncommon presentation. In addition, many studies around the world have revealed that the liver is injured to various degrees in patients with severe acute respiratory syndrome coronavirus 2 disease. This review mainly focuses on the impact of COVID-19 on Liver Injury at various ages. 相似文献
3.
miR‐155 expression and correlation with clinical outcome in pediatric AML: A report from Children's Oncology Group
下载免费PDF全文
![点击此处可从《Pediatric blood & cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
5.
Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition 总被引:2,自引:7,他引:2
下载免费PDF全文
![点击此处可从《Blood》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Brown P Meshinchi S Levis M Alonzo TA Gerbing R Lange B Arceci R Small D 《Blood》2004,104(6):1841-1849
Pediatric acute myelogenous leukemia (AML) has a poor prognosis, and novel therapies are needed. The FLT3 tyrosine kinase represents a promising target in pediatric AML. FLT3 is constitutively activated either by an internal tandem duplication (ITD) or by a point mutation (PM) in 17% to 24% of pediatric AML cases. Autocrine stimulation of wild-type (WT) FLT3 by coexpressed FLT3 ligand (FL) occurs in many other cases. FLT3/ITD mutations confer a particularly poor prognosis in pediatric AML patients. Inhibitors of FLT3 are being tested in adult AML patients, with promising preliminary results. In this study, cytotoxicity and apoptosis assays were performed on 44 diagnostic pediatric AML blast samples (14 FLT3/WT, 15 FLT3/ITD, 15 FLT3/PM) using CEP-701, a potent and selective FLT3 inhibitor. Pronounced cytotoxicity and induction of apoptosis were observed in a higher percentage of FLT3/ITD samples (93%) than FLT3/PM (27%) or FLT3/WT (29%). The cytotoxicity was greatest in samples with a high FLT3/ITD mutant-to-wild-type allelic ratio. The addition of FL enhanced the survival and augmented the sensitivity to FLT3 inhibition for the CEP-701-responsive subset of FLT3/WT and FLT3/PM samples. Clinical testing of FLT3 inhibitors as molecularly targeted agents for the improvement of outcome of pediatric AML patients is warranted. 相似文献
6.
Radiologic resolution of malignant infantile osteopetrosis skeletal changes following hematopoietic stem cell transplantation
下载免费PDF全文
![点击此处可从《Pediatric blood & cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
7.
Primary tumors of the inferior vena cava (IVC) are rare. The most common primary malignancy is leiomyosarcoma (LMS), with a severe prognosis. Right‐atrium (RA) involvement is seen in about 20 percent of cases. We report the case of a 53‐year‐old woman admitted to the intensive care unit because of progressive dyspnea with lower limb edema. Echocardiography demonstrated a large mass in the RA. At open‐heart surgery, the tumor appeared located in the IVC infrahepatic segment, completely obstructing the lumen and extending into the suprahepatic portion and the RA. Histopathological examination concluded to LMS. 相似文献
8.
Khezri Mehrdad Shokoohi Mostafa Mirzazadeh Ali Tavakoli Fatemeh Ghalekhani Nima Mousavian Ghazal Mehmandoost Soheil Kazerooni Parvin Afsar Haghdoost Ali Akbar Karamouzian Mohammad Sharifi Hamid 《AIDS and behavior》2022,26(9):2831-2843
AIDS and Behavior - Injection drug use has been the leading route of HIV transmission in Iran. We assessed HIV prevalence, risk behaviors, and uptake of prevention services among people who inject... 相似文献
9.
Acute myeloid leukemia (AML) remains the most common form of leukemia and the most common cause of leukemia death. Although conventional chemotherapy can cure between 25 and 45% of AML patients, most patients will either die of relapse or die from the complications associated with treatment. Thus, more specific and less toxic treatments for AML patients are needed. Recently, a small molecular inhibitor (STI571 or Gleevec) that targets the BCR-ABL gene was found to have a dramatic clinical effect in patients with chronic myelogenous leukemia (CML). These results have encouraged investigators to search for additional small molecular inhibitors and other targeted therapies that may be applicable to other forms of leukemia. In this review, we examine some of the signaling pathways that are aberrantly regulated in AML, focusing on the tyrosine kinase/RAS/MAP kinase and JAK/STAT pathways. After reviewing these two pathways, we explore some of the targeted therapies directed at these pathways that are under development for AML, many of which are already in clinical trials. 相似文献
10.
Loken MR Alonzo TA Pardo L Gerbing RB Raimondi SC Hirsch BA Ho PA Franklin J Cooper TM Gamis AS Meshinchi S 《Blood》2012,120(8):1581-1588
Early response to induction chemotherapy is a predictor of outcome in acute myeloid leukemia (AML). We determined the prevalence and significance of postinduction residual disease (RD) by multidimensional flow cytometry (MDF) in children treated on Children's Oncology Group AML protocol AAML03P1. Postinduction marrow specimens at the end of induction (EOI) 1 or 2 or at the end of therapy from 249 patients were prospectively evaluated by MDF for RD, and presence of RD was correlated with disease characteristics and clinical outcome. Of the 188 patients in morphologic complete remission at EOI1, 46 (24%) had MDF-detectable disease. Those with and without RD at the EOI1 had a 3-year relapse risk of 60% and 29%, respectively (P < .001); the corresponding relapse-free survival was 30% and 65% (P < .001). Presence of RD at the EOI2 and end of therapy was similarly predictive of poor outcome. RD was detected in 28% of standard-risk patients in complete remission and was highly associated with poor relapse-free survival (P = .008). In a multivariate analysis, including cytogenetic and molecular risk factors, RD was an independent predictor of relapse (P < .001). MDF identifies patients at risk of relapse and poor outcome and can be incorporated into clinical trials for risk-based therapy allocation. This study was registered at www.clinicaltrials.gov as NCT00070174. 相似文献