全文获取类型
收费全文 | 180篇 |
免费 | 10篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 8篇 |
基础医学 | 16篇 |
临床医学 | 6篇 |
内科学 | 62篇 |
皮肤病学 | 2篇 |
神经病学 | 2篇 |
特种医学 | 1篇 |
外科学 | 31篇 |
药学 | 15篇 |
肿瘤学 | 46篇 |
出版年
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 2篇 |
2015年 | 4篇 |
2014年 | 3篇 |
2013年 | 7篇 |
2012年 | 9篇 |
2011年 | 6篇 |
2010年 | 7篇 |
2009年 | 5篇 |
2008年 | 8篇 |
2007年 | 7篇 |
2006年 | 10篇 |
2005年 | 23篇 |
2004年 | 16篇 |
2003年 | 8篇 |
2002年 | 7篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1979年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有190条查询结果,搜索用时 15 毫秒
1.
H Meguro O Arimasu H Sohda J Yoshida K Togasaki R Fujii 《The Japanese journal of antibiotics》1986,39(4):1007-1019
A new beta-lactamase-stable oral cephem antibiotic, cefixime (CFIX), was evaluated for safety, efficacy and pharmacokinetics in children. CFIX was effective in 19 of 20 cases (95%) with bacterial infections. The drug was especially effective against the cases of pneumonia due to beta-lactamase-producing H. influenzae or B. catarrhalis. Pharmacokinetic parameters of CFIX (3 mg/kg) with premeal administration were as follows: Kel 0.328 +/- 0.066 hr-1, T 1/2 2.14 +/- 0.36 hrs, AUC 10.9 +/- 8.7 micrograms X hr/ml, and Vd/F 1.64 +/- 1.42 L/kg. In most of the cases tested, the urinary excretion rate in 12 hours was 5 to 17%. A dose of 3 mg/kg twice daily seems to be adequate for a regular treatment. 相似文献
2.
A Faried M Nakajima M Sohda T Miyazaki H Kato H Kuwano 《European journal of surgical oncology》2005,31(4):410-414
AIMS: The aim of this study was to clarify the clinico-pathologic outcome and prognostic significance of RhoA in esophageal squamous cell carcinoma (ESCC). METHODS: Immunohistochemical staining for RhoA was performed on surgical specimens obtained from 122 patients with ESCC. RESULTS: There were significant correlations among RhoA overexpression and TNM clinical classification (depth of invasion, P=0.028; presence of regional lymph node metastasis, P=0.009; presence of distant metastasis, P=0.003; staging P=0.006), lymphatic invasion (P=0.002), and blood-vessel invasion (P=0.004). The five-year survival rates for ESCC patients with RhoA overexpression were significantly lower than those in patients with RhoA under-expression (P=0.002). CONCLUSIONS: Our results demonstrated immunohistochemically that the expression of RhoA protein appeared to be correlated with tumour progression of ESCC. Patients with RhoA overexpression tended to have poor prognosis compared with patients with RhoA under-expression. 相似文献
3.
K. Tsukada T. Miyazaki H. Katoh N. Masuda M. Fukuchi R. Manda Y. Fukai M. Nakajima M. Sohda H. Kimura H. Kuwano 《Digestive and liver disease》2006,38(4):240-244
BACKGROUND: Perioperative steroid therapy is often used in oesophageal cancer surgery and we evaluate the effect of this therapy on the secretory leukocyte protease inhibitor levels in the lungs (a major antiprotease in the conducting airways) and postoperative course in oesophageal cancer patients. METHODS: Twenty-one patients operated on for oesophageal cancer in 2003-2004 were treated with perioperative steroid therapy (250 mg of methylprednisolone intravenously 1 h before the operation). Fifteen consecutive patients operated on in 2002 served as a control group. Secretory leukocyte protease inhibitor in bronchoalveolar lavage fluid and the postoperative course in the two groups were compared. RESULTS: The mortality rate was 0% and there was no significant difference in the morbidity rate between the two groups. Days of intubation and systemic inflammatory response syndrome were significantly shorter for the steroid group. The bronchoalveolar lavage fluid secretory leukocyte protease inhibitor level was significantly higher in the steroid group than in the control group on postoperative days 2 and 3. The secretory leukocyte protease inhibitor level on postoperative day 3 was remarkably lower for the patients intubated for > or = 5 days and for those with pulmonary complications. CONCLUSION: Perioperative steroid therapy increased the bronchoalveolar lavage fluid secretory leukocyte protease inhibitor level and reduced the days of intubation and systemic inflammatory response syndrome in patients with oesophagectomy. 相似文献
4.
Tetsuro Sohda Takayuki Hanano Hisanori Miyamoto Yoko Kitano Kaoru Iwata Masanori Yokoyama Makoto Irie Yasuaki Takeyama Satoshi Shakado Shotaro Sakisaka 《Hepatology International》2008,2(2):258-261
An 80-year-old man was admitted to our hospital because of the rupture of the liver. Laboratory data showed iron-deficiency
anemia, although there was no liver dysfunction. A computed tomography scan showed large liver tumor with intraperitoneal
hemorrhage, and since a serum level of α-fetoprotein (AFP) was extremely high, we initially suspected a rupture of hepatocellular
carcinoma (HCC). Transarterial embolization was performed to stop bleeding from the tumor, followed by an endoscopic examination
that revealed advanced gastric cancer. Histological analysis revealed that both the gastric and the hepatic tumors were moderately
to poorly differentiated adenocarcinoma, as well as that both tumors were immunohistochemically positive for AFP. Finally,
we diagnosed AFP-producing gastric cancer associated with liver metastasis. Rupture of metastatic liver cancer is rare, and
accordingly, distinction from HCC is important, particularly for the cases of AFP-producing gastric cancer. 相似文献
5.
6.
Yokoyama K Anan A Iwata K Nishizawa S Morihara D Ueda S Sakurai K Iwashita H Hirano G Sakamoto M Takeyama Y Irie M Shakado S Sohda T Sakisaka S 《Journal of gastroenterology and hepatology》2012,27(6):1044-1050
Background and Aim: Percutaneous radiofrequency ablation (RFA) has been shown to be a highly effective treatment for hepatocellular carcinoma (HCC). We investigated the controllability of HCC and explored the algorithm of therapeutic strategy for HCC in patients who met the RFA criteria. Methods: We enrolled 472 patients with HCC who met the RFA criteria (≤ 3 nodules, ≤ 3 cm) and underwent RFA for initial therapy. Patients who underwent repeated RFA were evaluated retrospectively when HCC exceeded the RFA criteria, or the functional hepatic reserve progressed to Child–Pugh grade C. Results: Overall survival rates were: 1 year, 96%; 3 years, 79%; and 5 years, 56%. In 5 years, 14% of patients progressed to Child–Pugh grade C. Meanwhile, 47% of patients exceeded the RFA criteria. Annually, 8% of patients deviated from the RFA criteria. The percentage of patients who were able to receive RFA significantly decreased at the fourth session compared with up to the third session. The survival rates decreased at the rate of 7% annually until the third year after the initial RFA. Afterwards, it shifted to a decrease at the rate of 12% annually. In a multivariate analysis, the presence of hepatitis C virus infection and the existence of a single tumor were identified as significant independent factors contributing to probabilities exceeding the RFA criteria. Conclusions: HCC was controlled by RFA up to three RFA treatments and 3 years from the initial therapy. On this basis, we propose a “three (times) × 3 (years) index” for considering a shift from RFA to other treatment modalities. 相似文献
7.
Takanori Inose Tatsuya Miyazaki Shigemasa Suzuki Naritaka Tanaka Makoto Sakai Akihiko Sano Takehiko Yokobori Makoto Sohda Masanobu Nakajima Minoru Fukuchi Hiroyuki Kato Hiroyuki Kuwano 《Surgery today》2013,43(8):877-882
Purpose
Nonspecific esophageal motility disorder (NEMD) is a vague category that includes patients with poorly defined contraction abnormalities observed during esophageal manometry. This study investigated the therapeutic effects of the video-assisted thoracoscopic surgery (VATS) approach using long myotomy and fundopexy for NEMD.Methods
The VATS approach using myotomy and fundopexy was performed for 4 patients of NEMD between 2005 and 2008. A total of 4 patients with NEMD that underwent treatment at our institution were analyzed retrospectively.Results
The patients included 2 males and 2 females with a median age of 48 years (range 21–74 years). The median duration of NEMD symptoms was 58 months (range 4–108 months). Dysphagia was a primary symptom in all patients. Chest pain was a primary symptom in 3 of 4 patients (75 %). Treatment with medication was attempted before the operation. The median operative time was 344.5 min (range 210–476 min). The median time before starting oral feeding was 2.5 days (range 2–22 days). All patients achieved a significant improvement of their previous condition.Conclusions
The VATS approach using myotomy and fundopexy for NEMD is a good treatment in cases resistant to medication and balloon dilation. 相似文献8.
9.
Intestinal epithelial culture under an air‐liquid interface: a tool for studying human and mouse esophagi
下载免费PDF全文
![点击此处可从《Diseases of the esophagus》网站下载免费的PDF全文](/ch/ext_images/free.gif)
T. Yokobori S. Suzuki T. Miyazaki M. Sohda M. Sakai N. Tanaka D. Ozawa K. Hara H. Honjo B. Altan M. Fukuchi H. Ishii M. Iwatsuki K. Sugimachi T. Sudo T. Iwaya N. Nishida K. Mimori H. Kuwano M. Mori 《Diseases of the esophagus》2016,29(7):843-847
This study investigated whether an intestinal epithelial culture method can be applied to mouse and human esophageal cultures. The esophagi harvested from 1‐day‐old mice and adult humans were maintained in collagen gels. A commercially available culture medium for human embryonic stem cells was used for the human esophageal culture. We discovered that the intestinal epithelial culture method can be successfully applied to both mouse and human esophageal cultures. The long‐term cultured esophageal organoids were rod‐like luminal structures lined with myofibroblasts. We discovered that regeneration of the esophageal mucosal surface can be almost completely achieved in vitro, and the advantage of this method is that organoid cultures may be generated using host‐derived fibroblasts as a niche. This method is a promising tool for mouse and human research in intestinal biology, carcinogenesis, and regenerative medicine. 相似文献
10.
Sohda Makoto Saeki Hiroshi Kuwano Hiroyuki Sakai Makoto Sano Akihiko Yokobori Takehiko Miyazaki Tatsuya Kakeji Yoshihiro Toh Yasushi Doki Yuichiro Matsubara Hisahiro 《Esophagus》2021,18(3):663-668
Esophagus - n our previous nationwide survey report on esophageal perforation, we proposed the existence of cases with idiopathic esophageal perforation at a certain rate. To elucidate the clinical... 相似文献