全文获取类型
收费全文 | 2047篇 |
免费 | 127篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 108篇 |
妇产科学 | 67篇 |
基础医学 | 213篇 |
口腔科学 | 55篇 |
临床医学 | 219篇 |
内科学 | 411篇 |
皮肤病学 | 43篇 |
神经病学 | 127篇 |
特种医学 | 272篇 |
外科学 | 147篇 |
综合类 | 22篇 |
预防医学 | 92篇 |
眼科学 | 59篇 |
药学 | 226篇 |
中国医学 | 10篇 |
肿瘤学 | 57篇 |
出版年
2023年 | 15篇 |
2022年 | 12篇 |
2021年 | 20篇 |
2020年 | 20篇 |
2019年 | 50篇 |
2018年 | 83篇 |
2017年 | 48篇 |
2016年 | 59篇 |
2015年 | 48篇 |
2014年 | 86篇 |
2013年 | 97篇 |
2012年 | 87篇 |
2011年 | 106篇 |
2010年 | 103篇 |
2009年 | 81篇 |
2008年 | 76篇 |
2007年 | 53篇 |
2006年 | 50篇 |
2005年 | 31篇 |
2004年 | 45篇 |
2003年 | 72篇 |
2002年 | 56篇 |
2001年 | 41篇 |
2000年 | 24篇 |
1999年 | 13篇 |
1998年 | 51篇 |
1997年 | 56篇 |
1996年 | 67篇 |
1995年 | 51篇 |
1994年 | 44篇 |
1993年 | 47篇 |
1992年 | 15篇 |
1991年 | 7篇 |
1990年 | 14篇 |
1989年 | 37篇 |
1988年 | 34篇 |
1987年 | 33篇 |
1986年 | 37篇 |
1985年 | 24篇 |
1984年 | 18篇 |
1983年 | 11篇 |
1982年 | 23篇 |
1981年 | 16篇 |
1980年 | 11篇 |
1978年 | 7篇 |
1977年 | 13篇 |
1976年 | 12篇 |
1975年 | 16篇 |
1955年 | 29篇 |
1954年 | 99篇 |
排序方式: 共有2183条查询结果,搜索用时 15 毫秒
1.
2.
3.
Kamil Torres Anna Torres Grzegorz J. Staśkiewicz Andrzej Chrościcki Tadeusz Łoś Ryszard Maciejewski 《Surgical endoscopy》2009,23(9):2117-2123
Background Surgical procedures enhance production of pro- and anti-inflammatory cytokines and angiogenic factors that play a pivotal
role in the immunological response to surgical trauma and take part in the pathogenesis of tumor growth and adhesions formation.
The purpose of the study was to access the influence of low-pressure CO2 pneumoperitoneum on the inflammatory and angiogenic responses during the postoperative period after laparoscopy.
Methods The study group consisted of 40 patients, operated on due to cholelithiasis using standard-pressure (n = 20) and low-pressure (n = 20) CO2 pneumoperitoneum. Serum concentration of interleukin (IL)-6, IL-8, IL-10, vascular endothelial growth factor (VEGF)-A, and
endostatin were measured before and at 6, 24, and 48 h after surgery with commercially available enzyme-linked immunosorbent
assay (ELISA).
Results Concentrations of IL-6 increased significantly after the operations in both groups. No differences were observed between the
groups in regards to IL-6, IL-8, and IL-10 levels. Concentrations of VEGF-A measured at 6 and 48 h were significantly lower
in patients who underwent laparoscopies performed with low-pressure pneumoperitoneum. No significant variations were observed
in endostatin serum concentration. Concentrations of the studied parameters were not influenced by duration of surgery or
by age, gender, or body mass index (BMI) of the patients.
Conclusions The results obtained in our study do not show any significant differences between studied operative procedures with regards
to systemic inflammatory response. Changes in the concentrations of VEGF-A and endostatin observed in the studied population
may suggest this technique is more favorable with regards to angiogenesis process intensity, along with all its consequences
and implications. 相似文献
4.
ME BURGE AM JOSHUA CM McNEIL R HUI MJ BOYER R ABRAHAM 《Asia-Pacific Journal of Clinical Oncology》2005,1(1):47-52
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma. 相似文献
5.
6.
7.
The aim of the study was the investigation of the biochemical condition of elements likely to directly participate in active
closing of the urethral lumen. We estimated glycogenolysis in urinary bladder, perivesical connective tissue and levator ani
muscle (LAM) samples obtained intraoperatively from 80 stress incontinent women. Glycogen content as well as activities of
active and total glycogen phosphorylase and acid exo-1,4-alpha-glucosidase were measured. Material from the urinary bladder
and perivesical connective tissue was insignificantly altered, and glycogen contents in the bladder (2.03±1.38 g/100 g wet
tissue) were considered to be normal. In the LAM glycogenolysis was much more activated than in other tissues (p<0.001 by
Fischer's exact test). Of LAM specimens 78% (22/28) revealed imbalanced biochemistry of glycogen with activation of hydrolytic
decomposition. We conclude that stress urinary incontinence in women is frequently associated with metabolic alterations in
the periurethral striated fibres. This study indirectly supports our recent hypothesis on the pathogenesis of the disease
in terms of muscle fibre type transitions. 相似文献
8.
9.