Follow-up study of reiter's disease and reactive arthritis. Factors influencing the natural course and the prognosis

Clinical Rheumatology - The acute clinical picture and long-term prognosis of 160 patients with Reiter's disease (RD), and 144 patients with reactive arthritis triggered by yersinia infection...     

Calcium Status and Calcium-Regulating Hormones in Alcoholics

To elucidate effects of chronic ethanol consumption on clinical chemical parameters reflecting overall calcium homeostasis 34 hospitalized male alcoholics and 35 age-matched controls were studied during the winter season. Serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 were reduced by 28% (p less than 0.01) and 24% (p less than 0.02) among the alcoholics as compared to the controls, respectively. Dietary intake of vitamin D3 did not differ significantly between the groups. The calcium level was below lower limit of reference in nine alcoholics (26%). Serum concentrations of parathyroid hormone and phosphorus were within normal ranges in both groups, and no differences were observed in levels of magnesium, vitamin D-binding protein, calcitonin, or alkaline phosphatase. In conclusion, it is possible that the activities of enzymes crucial in vitamin D3 metabolism may be altered in alcoholics.     

Some Aspects of Antioxidant Status in Blood from Alcoholics

The effect of ethanol consumption on serum concentration of alpha-tocopherol, erythrocyte activities of superoxide dismutase, glutathione peroxidase, and catalase were studied in 34 male alcoholics and 35 age-matched controls. Serum concentration of alpha-tocopherol was 30% lower in the alcoholics as compared to the controls (p less than 0.001). No significant difference was found in erythrocyte activities of Cu-Zn-containing superoxide dismutase, glutathione peroxidase, or catalase between the groups. Of the 12 alcoholics with subnormal serum alpha-tocopherol, 50% had concomitant neurological clinical scores and cerebellar atrophy, and their neurological scores were significantly higher (82%) than for alcoholics with normal alpha-tocopherol levels (p less than 0.03). However, no significant correlation was observed between levels of alpha-tocopherol and neurological clinical scores or cerebellar atrophy. When entering the study, alcoholics and controls were each randomized into two separate groups, receiving vitamin E supplementation (100 mg/day) or placebo capsules for 10 days, respectively. In the four subgroups, alpha-tocopherol levels increased only in alcoholics receiving vitamin E supplementation (23%) (p less than 0.001). The reduced serum levels of alpha-tocopherol in alcoholics may be normalized by vitamin E supplementation.     

Health and lifestyle characteristics of professional singers and instrumentalists.

Ninety-one instrumentalists and 51 opera singers of the Royal Theatre in Copenhagen, Denmark, were examined, in order to study the frequency of symptoms from the musculoskeletal system and upper airways. The response rate was 91 per cent. Estimates of odds ratios (OR) with 95 per cent confidence interval were calculated, using multiple logistic regression equations, adjusting for age and gender. The frequency of musculoskeletal complaints was the same in singers and instrumentalists. Musculoskeletal problems were however not identical. Instrumentalists had statistically significantly more symptoms from the arm region than singers, OR = 3.1 (1.02-9.5), P less than 0.05. In contrast, instrumentalists had significantly fewer complaints from hip-, knee- and foot joints than singers, OR = 0.2 (0.07-0.61), P less than 0.001. Singers had significantly more symptoms from mouth, lips or throat than instrumentalists, OR = 4.5 (1.7-11.5), P = 0.002. Both male and female instrumentalists had a higher blood pressure. This difference seemed at least in part to be explained by a higher alcohol intake among instrumentalists. We suggest these differences in life style and health characteristics are likely to be caused by professional, ie occupational, work loads.     

Relation Between HLA-B27 and Clinical Features in Patients with Yersinia Arthritis

A study of 74 yersinia arthritis patients implied that the clinical picture of the disease may be modified by genetic background associated with the histocompatibility antigen B27 (HLA-B27). Sixty-six percent of patients were B27 positive. Joint symptoms were somewhat more severe in B27+ patients. Iritis, conjunctivitis, carditis, signs of urologic inflammation, and complete Reiter's triad occurred only in the B27+ group, whereas erythema nodosum was more common in B27— group. Several B27+ patients also had “B27+ rheumatic diseases,” such as ankylosing spondylitis or Reiter's disease, in their history.     

Followup study on patients with Reiter's disease and reactive arthritis, with special reference to HLA-B27

An analysis of 160 patients with Reiter's disease, 144 with yersinia arthritis, and 9 with salmonella arthritis was performed, Complete or incomplete Reiter's syndrome was observed in one-third of the patients with yersinia arthritis and in most of those with salmonella arthritis. During the followup period, chronic back pain and joint symptoms were frequent in all the patient groups. Patients who were HLA-B27 positive had a more severe acute disease (more frequent back pain, urologic symptoms, mucocutaneous manifestations, and a longer duration of the disease) and more frequent chronic back pain and sacroiliitis.     

Followup study on patients with reiter's disease and reactive arthritis,with special reference to HLA—B27

An analysis of 160 patients with Reiter's disease, 144 with yersinia arthritis, and 9 with salmonella arthritis was performed. Complete or incomplete Reiter's syndrome was observed in one-third of the patients with yersinia arthritis and in most of those with salmonella arthritis. During the followup period, chronic back pain and joint symptoms were frequent in all the patient groups. Patients who were HLA—B27 positive had a more severe acute disease (more frequent back pain, urologic symptoms, mucocutaneous manifestations, and a longer duration of the disease) and more frequent chronic back pain and sacroiliitis.