全文获取类型
收费全文 | 1566篇 |
免费 | 149篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 67篇 |
妇产科学 | 26篇 |
基础医学 | 198篇 |
口腔科学 | 26篇 |
临床医学 | 193篇 |
内科学 | 362篇 |
皮肤病学 | 17篇 |
神经病学 | 62篇 |
特种医学 | 257篇 |
外科学 | 116篇 |
综合类 | 25篇 |
预防医学 | 103篇 |
眼科学 | 5篇 |
药学 | 146篇 |
1篇 | |
中国医学 | 31篇 |
肿瘤学 | 76篇 |
出版年
2021年 | 14篇 |
2020年 | 10篇 |
2019年 | 15篇 |
2018年 | 14篇 |
2017年 | 12篇 |
2016年 | 19篇 |
2015年 | 25篇 |
2014年 | 20篇 |
2013年 | 26篇 |
2012年 | 47篇 |
2011年 | 52篇 |
2010年 | 42篇 |
2009年 | 49篇 |
2008年 | 43篇 |
2007年 | 47篇 |
2006年 | 46篇 |
2005年 | 45篇 |
2004年 | 32篇 |
2003年 | 28篇 |
2002年 | 38篇 |
2001年 | 30篇 |
2000年 | 24篇 |
1999年 | 43篇 |
1998年 | 49篇 |
1997年 | 51篇 |
1996年 | 55篇 |
1995年 | 56篇 |
1994年 | 55篇 |
1993年 | 53篇 |
1992年 | 28篇 |
1991年 | 16篇 |
1990年 | 25篇 |
1989年 | 54篇 |
1988年 | 39篇 |
1987年 | 46篇 |
1986年 | 51篇 |
1985年 | 37篇 |
1984年 | 38篇 |
1983年 | 31篇 |
1982年 | 29篇 |
1981年 | 32篇 |
1980年 | 23篇 |
1979年 | 14篇 |
1978年 | 24篇 |
1977年 | 16篇 |
1976年 | 20篇 |
1975年 | 21篇 |
1974年 | 10篇 |
1973年 | 12篇 |
1957年 | 8篇 |
排序方式: 共有1718条查询结果,搜索用时 15 毫秒
1.
2.
P S Houts J M Yasko M A Simmonds S B Kahn G W Schelzel K M Marconi M J Bartholomew 《Journal of clinical epidemiology》1988,41(9):875-881
Problem reporting rates of 180 persons with cancer (PWC) were compared with those of their closest in age same sex cancer-free siblings living outside their households for the same time periods. PWC had significantly higher reporting rates for physical, activities of daily living, nutrition, and emotional problems and a significantly lower rate for family problems. Sibling problem reporting rates, which indicate the likelihood that PWC would have experienced similar problems without a diagnosis of cancer, were highest for physical, emotional, employment, and family problems suggesting that noncancer factors are especially likely to play a role in those types of problems. Regression analyses showed that female and younger PWCs tended to report more problems than their siblings suggesting that they were more affected by cancer and its treatments than were other types of PWC. 相似文献
3.
RAFAEL BEYAR M.D. D.Sc. ARIEL ROGUIN M.D. JAAP HAMBURGER M.D. RE SAAIMAN M.D. ANTONIO L. BARTORELLI M.D. CARLO DiMARIO M.D. ANTONIO COLOMBO M.D. CHRISTIAN W. HAMM M.D. CHRISTOPHER J. WHITE M.D. J. MARCO M.D. PATRICK W. SERRUYS M.D. Ph.D. 《Journal of interventional cardiology》1997,10(4):277-286
The beStent is a new stainless steel, balloon-expandable mesh stent which has a unique serpentine design. Rotation of the unique low stress junctions upon expansion leads to orthogonal locking of the wires, maximizing radial strength and assuring zero shortening. The stent has delineating gold markers which assure precise positioning. We aim to present the initial acute results in a pilot registry for stent evaluation. Two hundred eighty-four stents were used in a total of 217 patients (age 57.9 ± 3.10 years; 178 males; 39 females) in seven centers, for variable indications. Stents of 15-, 25-, and 35-mm length were used. The arteries treated were the left anterior descending (n = 112, 42%), circumflex (n = 54, 20.2%), right coronary (n = 95, 35.5%), left main (n = 1, 0.4%), and vein graft (n = 5, 1.9%). Lesion types were: A in 42 patients (16.5%); B1 in 53 patients (20.7%); B2 in 81 patients (31.8%); and C in 79 patients (31%). One hundred fifty-nine patients required one stent, 40 patients required two stents, and 18 patients required three or more stents. Anticoagulation protocol included procedural heparin with aspirin with/without ticlopidine. Smooth angiographie results were obtained in all cases with no plaque herniation. Acute angiographic success was obtained in 97% of the patients, and acute clinical success in 95% of the patients. Complications within 30 days were: 3 deaths (1.4%) (2 noncardiac); 2 (0.9%) myocardial infarctions; and 2 (0.9%) stent thromboses. Therefore, the beStent is useful in treatment of complex lesions of variable length and complexity, providing excellent acute results with a low complication rate, in spite of unfavorable basic clinical and angiographie characteristics. 相似文献
4.
5.
6.
7.
Celia Montero R.Tomasz Smolenski John A. Duley H.Anne Simmonds 《Biochemical pharmacology》1990,40(12):2617-2623
The mechanism by which S-adenosylmethionine (SAM) and adenosine (Ado) increase ATP levels in intact human erythrocytes in vitro has been compared. The use of erythrocytes from healthy controls and from subjects totally deficient in adenine phosphoribosyltransferase (APRT), plus inhibitors of adenosine kinase (AK) and adenosine deaminase (ADA) separately and together, has enabled us to demonstrate that this increment in ATP levels occurred via totally different metabolic routes. The results show that: (i) whilst the Ado-induced increment in ATP was AK dependent, that produced by SAM was independent of AK; and (ii) the SAM-induced increment in ATP was totally dependent on APRT and that some of the increment produced by Ado might also be APRT dependent. The above data are consistent with the metabolism of SAM to ATP by a route recently identified by us whereby ATP is formed from deoxyadenosine: namely binding to the enzyme S-adenosylhomocysteine hydrolase with subsequent release of adenine and further conversion to ATP via APRT. 相似文献
8.
Studies were made on the potentiation of [3H]flunitrazepam binding to rat brain membranes by gamma-aminobutyric acid (GABA), pentobarbitone and pregnanolone (5 beta-pregnan-3 alpha-ol-20-one). Epipregnanolone, the 3 beta isomer of pregnanolone, inhibited competitively the potentiation by pregnanolone with a Ki of 10.5 microM without affecting that of GABA. The potentiation by pentobarbitone was slightly enhanced. Epipregnanolone alone showed only slight potentiation of benzodiazepine binding. These findings demonstrate that epipregnanolone is a specific antagonist of the neurosteroid site of the GABAA receptor and raise the possibility of a physiological role for 3 beta-hydroxysteroids in modulating this receptor. 相似文献
9.
10.
M. G. Bradbury M. Henderson J. T. Brocklebank H. A. Simmonds 《Pediatric nephrology (Berlin, Germany)》1995,9(4):476-477
A 9-month-old child with the skeletal abnormalities of Fuhrmann's syndrome presented with acute renal failure secondary to bilateral renal calculi. Hereditary xanthinuria was shown to be the underlying metabolic defect. Treatment with allopurinol was unsuccessful at reducing the xanthine excretion. 相似文献