新冠肺炎疫情下艾灸防治帕金森病的临床应用分析＊

帕金森病（Parkinson''s disease，PD）是仅次于阿尔茨海默病的世界第二大神经系统退行性疾病，随着老龄化社会的到来，PD患病率呈明显上升趋势。全球爆发的新型冠状病毒肺炎（简称新冠肺炎）是一种急性传染性疾病，严重威胁人们的身体健康和生命安全。PD患者大多为老年人且合并有基础疾病，体质普遍较弱，是新冠肺炎的易感人群，一旦染病则发展为重症的风险很高。中医艾灸疗法在治疗PD及防治疫病方面发挥了很好的辅助治疗效果。通督扶阳灸法联合强壮穴艾灸治疗，既可以帮助PD患者改善临床症状，延缓病情进展，又可以提高机体免疫功能，增强抗病能力而防治新冠肺炎。     

Clinical joints manifestations in patients with psoriatic arthritis on musculoskeletal ultrasound

Clinical Rheumatology - To investigate the clinical joints manifestations under musculoskeletal ultrasound (MSUS) and hematological findings in patients with psoriatic arthritis (PsA), which may...     

Acupuncture and moxibustion reduces neuronal edema in Alzheimer’s disease rats

To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer's disease, we established a rat model of Alzheimer's disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacu-puncture, or both, at Baihui(GV20) and Shenshu(BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuro-protective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway.     

应用护理程序制定护理工作流程及应急预案

为加强护理工作管理、规范护理行为、保证护理安全,使护理工作科学化、程序化,我院应用护理程序制定了护理工作流程及应急预案,强化护士回避护理风险、防范事故的责任意识,提高了护理工作质量和效率,改善了护患关系,增加了患者满意度.     

护士工作价值观与工作满意度的调查研究

[目的]了解护士工作价值现、工作满意度现状,探讨可能对工作满意度有影响的因素以及工作价值观与工作满意度的相互关系.[方法]采取随机抽样方法抽取某医院117名护理人员,采用工作价值观量表、护士工作满意度量表进行调查.[结果]护士技术职称对满意度有显著的正向预测力;护士的工作价值观与工作满意度呈正相关(P＜0.01或P＜0.05).[结论]护士对工作的满意程度有赖于各方面满意感的获得.护理管理者应重视护士工作价值观对工作满意程度的影响.     

应用全自动生化分析仪测定缺血修饰白蛋白

目的建立白蛋白钴结合(ACB)试验检测缺血修饰白蛋白(IMA)。方法应用日立7600型全自动生化分析仪,采用ACB法测定IMA,并测定血清中不同白蛋白浓度,以观察白蛋白对其影响。结果ACB方法批内变异系数(CV)为5.0%,批间CV为1.6%。不同浓度的人血清白蛋白ACB法测定结果是线性的,回归方程为Y=0.029 1.57X,r=0.995,P=0.000。黄疸对测定无明显影响;溶血(5 g/dL)和脂血(0.4%)对测定有干扰。健康人群参考范围为79.6 U/mL。结论IMA是评价心肌缺血的有效诊断工具,采用全自动生化分析仪建立测定IMA的方法方便、简单,可以大批量测定。     

Identification of nafamostat mesylate as a selective stimulator of NK cell IFN-γ production via metabolism-related compound library screening

Natural killer (NK) cells play important roles in controlling virus-infected and malignant cells. The identification of new molecules that can activate NK cells may effectively improve the antiviral and antitumour activities of these cells. In this study, by using a commercially available metabolism-related compound library, we initially screened the capacity of compounds to activate NK cells by determining the ratio of interferon-gamma (IFN-γ)⁺ NK cells by flow cytometry after the incubation of peripheral blood mononuclear cells (PBMCs) with IL-12 or IL-15 for 18 h. Our data showed that eight compounds (nafamostat mesylate (NM), loganin, fluvastatin sodium, atorvastatin calcium, lovastatin, simvastatin, rosuvastatin calcium, and pitavastatin calcium) and three compounds (NM, elesclomol, and simvastatin) increased the proportions of NK cells and CD3⁺ T cells that expressed IFN-γ among PBMCs cultured with IL-12 and IL-15, respectively. When incubated with enriched NK cells (purity?≥?80.0%), only NM enhanced NK cell IFN-γ production in the presence of IL-12 or IL-15. When incubated with purified NK cells (purity?≥?99.0%), NM promoted NK cell IFN-γ secretion in the presence or absence of IL-18. However, NM showed no effect on NK cell cytotoxicity. Collectively, our study identifies NM as a selective stimulator of IFN-γ production by NK cells, providing a new strategy for the prevention and treatment of infection or cancer in select populations.

     

X线胃肠机改良颞颌关节摄片法的临床应用

目的 探讨X线胃肠机透视定位及带摇控、自动换片、胶片自动分隔等优点在改良颢颌关节许勒氏位中的临床应用。方法 采用日本岛津500 mA X线胃肠机，自制角度板，透视下定位摄片，并与传统摄片方法照片进行比较。结果 96例颞颌关节病患者，有94例通过该方法摄片，与传统摄片方法相比，结果新的摄片法具有定位精确，成像标准，摄片成功率高达98％等优点。结论 应用X线胃肠机对许勒氏位改良摄片改进传统方法存在的缺点，为X线胃肠机在口腔X线影像学方面的应用开拓了新的应用范围。     

生物制剂治疗银屑病关节炎的研究进展

银屑病关节炎（PsA）是与银屑病相关,具有潜在致残性的炎性自身免疫病,因其易反复而迁延不愈,可致残甚至死亡,严重影响患者的生活质量。目前其治疗仍是令人困惑的问题,多数借鉴类风湿性关节炎的经验,包括传统的抗风湿药、非甾体类消炎药、糖皮质激素等。     

乳腺纤维瘤的超声诊断价值

目的探讨彩色超声对乳腺纤维瘤诊断的价值,提高乳腺纤维瘤患者的早期诊断率。方法选择2009年12月-2011年11月本院做乳腺检查的60例乳腺纤维瘤患者,使用美国GELogic7彩色多普勒超声诊断仪．探头频率为5-12MHz。结果（1）典型的声像图表现的患者为46例,非典型的患者为14例;（2）手术病理证实有38例乳腺纤维瘤,占全部的63-3％。结论彩色超声可以用来作为乳腺纤维瘤的诊断依据,为临床治疗提供了重要依据,值得在基层医院进一步推广使用。