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排序方式: 共有2937条查询结果,搜索用时 15 毫秒
1.
Hironori Nakagami Yasushi Kikuchi Tomohiro Katsuya Ryuichi Morishita Hiroshi Akasaka Shigeyuki Saitoh Hiromi Rakugi Yasufumi Kaneda Kazuaki Shimamoto Toshio Ogihara 《Hypertension research》2007,30(12):1239-1246
We examined a gene polymorphism of a novel Z-disc-related protein, myospryn (cardiomyopathy-associated 5). We focused on one haplotype block associated with a tag single nucleotide polymorphism (SNP) that covered 16 of 27 coding SNPs with linkage disequilibrium (minor allele frequency 0.413). Screening a myospryn polymorphism (K2906N) in a general health check-up of a rural Japanese population revealed an association with cardiac diseases (p=0.0082). In further analysis of the interaction between K2906N and cardiac function in patients, K2906N was associated with the anteroseptal wall thickness of the left ventricle in a recessive model (p=0.0324) and with the ratio of the peak velocity of the early diastolic filling wave to the peak velocity of atrial filling (A/E) (p=0.0278). In an association study based on left ventricular wall thickness, we found a significant difference in the K2906N genotype between controls and patients with cardiac hypertrophy. These results suggest that the K2906N polymorphism could be clinically associated with left ventricular hypertrophy and diastolic dysfunction independent of known parameters. Although the precise mechanism underlying this association remains to be elucidated, treatment with angiotensin II induced an increase in heart myospryn mRNA level in vitro and in vivo. Our results suggest that the polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload. 相似文献
2.
1. Whether bradykinin (BK), which is known as an endogenous pain-producing substance, induces augmentation of the discharges of polymodal receptors evoked by heat stimulation was investigated in in vitro canine testis-superior spermatic nerve preparations. 2. The heat response was significantly augmented by pretreatments with BK at concentrations greater than 0.094 nM, whereas BK induced significant increases in the mean discharge rates at concentrations above 9.4 nM. Both effects increased in a concentration-dependent manner. The augmenting effect of BK on the heat response diminished within 10 min after application of BK, regardless of concentration. 3. When 9.4 nM BK was applied in a mixture with 940 nM NPC349, a B2 receptor antagonist, the averaged mean discharge rate evoked by BK and the averaged augmenting effect were both significantly suppressed compared with those induced by BK given alone. 4. The augmenting effect of BK on the heat response of polymodal receptors could be observed even in the absence of BK-evoked discharges per se in several cases in which low concentrations of BK or BK plus B2 antagonists were given. 5. These findings suggest that the augmenting effects of BK on the heat response depend on B2 receptor-mediated intracellular processes acting in parallel to, but not directly on, the impulse-generation mechanism of the heat response of the polymodal receptor. 相似文献
3.
4.
Matsukawa T.; Hanagata K.; Ozaki M.; Iwashita H.; Koshimizu M.; Kumazawa T. 《British journal of anaesthesia》1997,78(4):396-399
We tested the hypothesis that premedication with i.m. midazolam decreases
core temperature dose-dependently. We studied six male volunteers, in
random order, on 3 days: (1) no midazolam administration (control day), (2)
midazolam 0.025 mg kg-1 i.m., (3) midazolam 0.075 mg kg-1 i.m. On the first
day, subjects were maintained alert during a 30- min control period. On the
second and third days, midazolam 0.025 or 0.075 mg kg-1 was administered
i.m. Core temperatures were measured at the right tympanic membrane. Four
adhesive skin surface probes were fixed on the chest, upper right arm,
lateral calf and thigh. Finger tip perfusion was evaluated using forearm
minus fingertip and calf minus toe, skin surface temperature gradients.
Thirty minutes after midazolam i.m., the level of sedation in the
volunteers was assessed. Peripheral venous blood was obtained immediately
after the assessment of the level of sedation. Tympanic membrane
temperatures after administration of midazolam 0.075 mg kg-1 i.m. were
significantly lower than those on the control and midazolam 0.025 mg kg-1
i.m. days at 20 and 30 min. The decreases in tympanic membrane temperatures
at 30 min after midazolam i.m. became larger as the volunteers were more
deeply sedated. i.m. midazolam produced a concentration-dependent decrease
in tympanic membrane temperature at 30 min after midazolam 0.025 and 0.075
mg kg-1 i.m. We conclude that midazolam impaired tonic thermoregulatory
vasoconstriction, allowing core-to-peripheral heat redistribution in a
dose-dependent manner after i.m. administration.
相似文献
5.
Clitoral involvement by neurofibromatosis: a case report and review of the literature 总被引:1,自引:0,他引:1
We report a case of clitoral involvement by neurofibromatosis in which the clitoris resembled a phallus. The patient was treated successfully by clitoroplasty. This is the seventh such case reported in the English literature. 相似文献
6.
Sugie Shigeyuki; Yoshimi Naoki; Tanaka Takuji; Mori Hideki; Williams Gary M. 《Carcinogenesis》1994,15(1):95-98
The nuclear pore density and area were measured on freeze-fracturednuclei of ACI/N rat liver altered foci, adenomas and carcinomasinduced by 2-acetylaminofluorene, and compared with those ofnormal hepatocytes. The pore density of nuclei from these preneoplasticand neoplastic lesions was significantly higher than that ofhepatocytes, but there was no difference between lesions. Thearea of nuclear pores of the focus cells did not differ fromnormal hepatocytes, whereas the areas of pores of adenoma andcarcinoma cells were increased. Moreover, the nuclear pore areaof carcinomas was significantly greater than that of adenomas.These results suggest that some changes may occur in nuclearpores in the progress of tumorigenesis. 相似文献
7.
Shigeyuki Takatsuka Kan Yoshida Koichiro Ueki Kohei Marukawa Kiyomasa Nakagawa Etsuhide Yamamoto 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,99(5):614-621
OBJECTIVE: The purpose of this study was to elucidate causal relationship between disc and condyle range of movement and clinical signs and symptoms in patients with temporomandibular disorders (TMD), using magnetic resonance imaging (MRI). STUDY DESIGN: The subjects comprised of a study group of 191 patients with TMD and a control group of 43 asymptomatic patients. The clinical assessment consisted of range of maximum mouth opening (MMO) and preauricular pain during mandibular function. After clinical and radiographic findings assessment, disc and condyle condition were examined by MRI and the range of movement was accordingly classified. RESULTS: Disc displacement was observed in 156/191 (81.7%) of the study group and 9/43 (20.9%) of the control group. When disc and condyle mobility was presented around the eminence, wider MMO range was maintained, P < .05. Presence of osteoarthrosis (OA) was not correlated with preauricular pain, because OA variables were mild in the study group. CONCLUSION: Maintenance of disc/condyle translation is an important factor in TMJ function, irrespective of disc displacement or arthritis. 相似文献
8.
Clinical characteristics of thrombotic microangiopathy following ABO incompatible living donor liver transplantation. 总被引:1,自引:0,他引:1
Ryohei Miyata Motohide Shimazu Minoru Tanabe Shigeyuki Kawachi Ken Hoshino Go Wakabayashi Yoko Kawai Masaki Kitajima 《Liver transplantation》2007,13(10):1455-1462
Thrombotic microangiopathy (TMA) may develop after living donor liver transplantation (LDLT), but the mechanism is not fully understood. We retrospectively analyzed all patients undergoing LDLT at our center, including TMA patients, to elucidate the clinical characteristics and presentation and to determine which patients have a higher risk of occurrence of TMA. In all, 57 adult patients were reviewed after LDLT at our institution. TMA was diagnosed by sudden and severe thrombocytopenia, followed by hemolytic anemia with fractionated erythrocytes in the blood smear. Clinical features were compared between the TMA group and the non-TMA group. Of the 57 patients, 4 were diagnosed with posttransplantation TMA. ABO blood group (ABO)-incompatibility, cyclophosphamide (CPA), and recipient blood group (type O) were closely correlated with the occurrence of TMA. Thrombocytopenia appeared 1 to 5 days before hemolytic anemia. Coagulative function markers stayed at the same level after TMA, while marked elevation was shown in fibrinolytic function markers such as plasminogen activator inhibitor type 1 (PAI-1). TMA occurred at a higher prevalence in ABO-incompatible graft recipients. Additional factors associated with ABO-incompatible transplantation, such as an overdose of immunosuppressants, may affect the likelihood of TMA. Sudden and severe thrombocytopenia presented before hemolytic anemia and the serum levels of PAI-1 correlated well with the clinical course of TMA. In conclusion, early recognition of thrombocytopenia and elevation of PAI-1 is crucial to diagnose TMA especially in ABO-incompatible LDLT. 相似文献
9.
Ruri Aoki Tetsuya Arinobu Takeshi Kumazawa Hideki Hattori Hiroshi Noguchi 《Forensic Toxicology》2007,25(1):8-15
An automated on-line method for simultaneous analysis of five phenothiazine drugs by high-performance liquid chromatography
(HPLC)/sonic spray ionization mass spectrometry (SSI-MS) has been established, using backflush column switching. A 400-μl
portion of serum sample diluted 81-fold with distilled water was subjected to the on-line system. In the system, an Oasis
HLB cartridge was used as the precolumn for extraction; large molecules such as proteins in serum were discarded by use of
distilled water containing 0.1% formic acid as a mobile phase. After switching a valve, the analytes trapped in the precolumn
were eluted in the backflush mode and separated by a Chromolith Performance RP-18e column, which is composed of C18-bonded monolithic silica. The column effluents were then introduced into the SSI-MS. The present method provided successful
separation and determination of six phenothiazines including an internal standard. Satisfactory linearities, reproducibility,
and sensitivity were obtained at concentration levels that matched the toxic levels of phenothiazines. All drug peaks appeared
within 18 min, and the system could be reequilibrated in only about 8 min for the next run. Because of the simplicity and
rapidness of the method, it is likely to be useful in the fields of emergency medicine and forensic toxicology. 相似文献
10.
Shigeyuki Sasaki Keishu Yasuda James D. McCully Joseph LoCicero III 《Surgery today》1997,27(12):1154-1159
The purpose of this study was to develop an isolated, pulsatile blood-perfused rat lung model that allows us to evaluate the
preserved lung functions. Lungs isolated from Sprague-Dawley rats, were perfused with venous whole blood by either a pulsatile
or constant flow. The effuent was continuously deoxygenated with a 95% N2/5% CO2 gas mixture. Airway resistance, lung compliance, elastic work, flow resistive work, pulmonary vascular resistance, and blood
gas analysis were assessed. Pressor responses toN
G
-monomethyl-l-arginine (l-NMMA) were compared between pulsatile and constant blood flow. At a flow of 0.1 ml/g body weight/min, pulsatile perfusion
allowed for stable perfusion at least for 2h (mean 162.5±15.1 min) with stable aerodynamic and hemodynamic variables including
blood gas tensions, whereas constant perfusion resulted in immediate lung failure. Whenl-NMMA was added to the perfusate, the mean pulmonary artery pressure did not show any change in the constant flow (6.0±2.6%
increase), but did show a significant increase in the pulsatile flow (45±11% increase). Pulsatile blood flow reduced the pulmonary
vascular resistance relative to the constant flow and allowed for a 2-h perfusion period to evaluate the lung function. The
vasorelaxant mechanism in the pulsatile perfusion is related in part to the endothelial-dependent relaxation observed in the
nitric oxide pathway.
Presented in part at the 79th, Annual Clinical Congress of the American College of Surgeons (ACS) held in San Francisco, CA
USA, 1993. 相似文献