排序方式: 共有4条查询结果,搜索用时 46 毫秒
1
1.
Satish M. Kale Nikunj B. Mody Surendra B. Patil Pranam Sadawarte 《Indian Journal of Plastic Surgery》2015,48(2):204-207
A urethrocutaneous fistula is a common complication after hypospadias repair, but congenital fistula is a rare anomaly. We present a 16-year-old boy with this unusual anomaly. Its etiology, embryology, and management are discussed in brief.KEY WORDS: Adolescent, congenital fistula of penile urethra, urethroplasty 相似文献
2.
3.
S. B. Bavdekar Pranjali A. Sadawarte Nithya J. Gogtay Surabhi S. Jain Sandhya Jadhav 《Indian journal of pediatrics》2009,76(11):1113-1118
Objective
To determine the extent and nature of off-label drug use in children admitted to a Pediatric Intensive Care Unit (PICU) 相似文献4.
Jyotsna Gokavi Sharwari Sadawarte Anant Shelke Urmila Kulkarni-Kale Madhuri Thakar Vandana Saxena 《Viruses》2021,13(11)
TGF-β has been shown to play a differential role in either restricting or aiding HIV infection in different cell types, however its role in the cervical cells is hitherto undefined. Among females, more than 80% of infections occur through heterosexual contact where cervicovaginal mucosa plays a critical role, however the early events during the establishment of infection at female genital mucosa are poorly understood. We earlier showed that increased TGF-β level has been associated with cervical viral shedding in the HIV infected women, however a causal relationship could not be examined. Therefore, here we first established an in vitro cell-associated model of HIV infection in the cervical epithelial cells (ME-180) and demonstrated that TGF-β plays an important role as a negative regulator of HIV release in the infected cervical epithelial cells. Inhibition of miR-155 upregulated TGF-β signaling and mRNA expression of host restriction factors such as APOBEC-3G, IFI-16 and IFITM-3, while decreased the HIV release in ME-180 cells. To conclude, this is the first study to decipher the complex interplay between TGF-β, miR-155 and HIV release in the cervical epithelial cells. Collectively, our data suggest the plausible role of TGF-β in promoting HIV latency in cervical epithelial cells which needs further investigations. 相似文献
1