全文获取类型
收费全文 | 2120篇 |
免费 | 118篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 64篇 |
妇产科学 | 20篇 |
基础医学 | 274篇 |
口腔科学 | 82篇 |
临床医学 | 144篇 |
内科学 | 445篇 |
皮肤病学 | 20篇 |
神经病学 | 75篇 |
特种医学 | 141篇 |
外科学 | 395篇 |
综合类 | 151篇 |
一般理论 | 2篇 |
预防医学 | 126篇 |
眼科学 | 55篇 |
药学 | 126篇 |
中国医学 | 5篇 |
肿瘤学 | 133篇 |
出版年
2023年 | 19篇 |
2022年 | 54篇 |
2021年 | 102篇 |
2020年 | 49篇 |
2019年 | 56篇 |
2018年 | 61篇 |
2017年 | 52篇 |
2016年 | 45篇 |
2015年 | 81篇 |
2014年 | 75篇 |
2013年 | 77篇 |
2012年 | 128篇 |
2011年 | 150篇 |
2010年 | 92篇 |
2009年 | 72篇 |
2008年 | 123篇 |
2007年 | 128篇 |
2006年 | 126篇 |
2005年 | 109篇 |
2004年 | 87篇 |
2003年 | 83篇 |
2002年 | 67篇 |
2001年 | 17篇 |
2000年 | 17篇 |
1999年 | 27篇 |
1998年 | 35篇 |
1997年 | 24篇 |
1996年 | 35篇 |
1995年 | 19篇 |
1994年 | 37篇 |
1993年 | 11篇 |
1992年 | 7篇 |
1991年 | 7篇 |
1990年 | 14篇 |
1989年 | 16篇 |
1988年 | 16篇 |
1987年 | 19篇 |
1986年 | 18篇 |
1985年 | 19篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1982年 | 6篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有2262条查询结果,搜索用时 265 毫秒
1.
2.
Shahid Husain Kenneth McCurry James Dauber Nina Singh Shimon Kusne 《The Journal of heart and lung transplantation》2002,21(3):354-359
BACKGROUND: Nocardia is responsible for infection in both normal and immunocompromised hosts. Organ transplant recipients are increasingly recognized as a sub-group of immunocompromised patients in whom nocardia is an important pathogen. The frequency of nocardia in organ transplant recipients varies between 0.7% and 3%. Nocardia infection has largely been reported in heart, kidney and liver transplant recipients. Presentations of nocardia in lung transplant recipients have been restricted primarily to case reports. The present study reviews the clinical and epidemiologic characteristics of nocardia infection in lung transplant recipients at our institution. METHODS: A retrospective cohort study of 473 lung transplant recipients from January 1991 to November 2000 was done at a university hospital. Patient demographics, immunosuppressive regimen at the time of isolation of nocardia species, use of trimethoprim-sulfamethoxazole for Pneumocystis carinii prophylaxis, rejection episodes in the preceding 6 months, concurrent pathogens, site of infection, radiologic findings and treatment and outcome were recorded. RESULTS: Nocardia infection was found in 2.1% (10 of 473) of our lung transplant recipients. Median time of onset was 34.1 months after transplantation. Nocardia species included N farcinica in 30% (3 of 10), N nova in 30% (3 of 10), N asteroides complex in 30% (3 of 10) and N brasiliensis in 10% (1 of 10) of patients. Post-transplant diabetes was present in 50% (5 of 10) of patients. The primary indication for lung transplantation was emphysema in 40% (4 of 10). Native lung involvement was noted in 75% (3 of 4) of patients with single lung transplant. Breakthrough nocardia infection were noted in 6 patients who were receiving trimethoprim-sulfamethoxazole prophylaxis for P carinii pneumonia; all breakthrough isolates remained susceptible to trimethoprim-sulfamethoxazole. Overall mortality was 40% (4 of 10). All patients (3 of 3) with infection due to N farcinica, except 1 (1 of 7) with infection due to other nocardia species, died. Seventy-five percent (3 of 4) of deaths were attributable to nocardia infection. CONCLUSIONS: Nocardia infection tended to involve the native lung in single lung transplant recipients. Trimethoprim-sulfamethoxazole for P carinii prophylaxis at the doses given was not protective against nocardiosis in these patients. Infection with N farcinica was associated with poor outcome. Thus, species identification and extended courses of antibiotics based on antimicrobial susceptibility testing are important in management of these patients. 相似文献
3.
4.
5.
6.
7.
HERMAN TOURNAYE RONNY JANSSENS PAUL DEVROEY RK VAN STEIRTEGHEM 《International journal of andrology》1994,17(1):1-8
In order to evaluate the effects of pentoxifylline on sperm motility and longevity, a controlled in-vitro study was conducted on normozoospermic donor semen samples using the Cellsoft automated system for sperm motility analysis. After incubation and selection, pentoxifylline was found to improve the recovery of spermatozoa and to increase their velocity. In the subgroup of progressively motile spermatozoa, curvilinear velocity was also enhanced. It is concluded that pentoxifylline has an effect on the vigour, but not on the pattern, of sperm motion. Pentoxifylline did not improve the motility characteristics of senescent spermatozoa in normozoospermic sperm samples. Sperm survival, as shown by supra-vital staining, and motility longevity both decreased with time after pentoxifylline treatment. 相似文献
8.
V. JNSSON H. D. SCHRDER W. TROJABORG T. STAEHELIN JENSEN E. HIPPE M. MRK HANSEN 《Journal of internal medicine》1992,232(2):185-191
A study of 17 patients with autoimmune axonal or demyelinating peripheral neuropathy in combination with M-component is described. The M-component was associated with MGUS (monoclonal gammopathy of undetermined significance) in 12 patients, CLL in one patient, WaldenstrÖm's disease in one patient, and myeloma in three patients. Immunohistological examination with direct and indirect fluorescence showed binding of antibodies to nerve structures of the same class and light chain as seen in the M-component. In five cases of IgM M-component, the demyelinating neuropathy was caused by binding of the IgM M-protein and complement C3b to myelin-associated glycoproteins (MAG). In 12 cases with axonal neuropathy, binding of IgG to the connective tissue of the peri- and endoneurium was found in 50% of cases, IgM in five cases, and IgD in one case. None of the patients had central nervous system (CNS) symptoms. The clinical and therapeutic difficulties are discussed; only two patients with an acute course responded to immunosuppression. A marked co-expression of other autoimmune phenomena is interpreted in the light of cross-reactions between the autoantibody and similar tissue autoantigens. 相似文献
9.
10.
Abdul Rahman Arishi M. Ezzedien Rabie M. Shahid Hussain Khan Hassan Sumaili Hassan Shaabi Nabil Tadros Michael Bheem Sing Shekhawat 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2008,12(3):321-325
Spillage of gallstones may occur in the course of laparoscopic cholecystectomy. The incidence of this mishap and its consequences are variable. Ignored by many surgeons, stone spillage may be the source of significant morbidity many years after surgery. In this report, we describe the clinical course of a patient who presented with upper abdominal pain and swelling. The past history was positive for laparoscopic cholecystectomy 15 years earlier. After excision, the swelling was found to be a pseudocyst formed around spilled gallstones during a previous cholecystectomy. Apart from postoperative wound infection, the patient recovered well and remains so. Here, we discuss the problem and provide suggestions for spillage prevention and stone retrieval once spillage occurs. 相似文献