全文获取类型
收费全文 | 4173篇 |
免费 | 289篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 179篇 |
妇产科学 | 115篇 |
基础医学 | 610篇 |
口腔科学 | 58篇 |
临床医学 | 359篇 |
内科学 | 900篇 |
皮肤病学 | 88篇 |
神经病学 | 515篇 |
特种医学 | 126篇 |
外科学 | 529篇 |
综合类 | 14篇 |
一般理论 | 2篇 |
预防医学 | 269篇 |
眼科学 | 39篇 |
药学 | 304篇 |
中国医学 | 6篇 |
肿瘤学 | 340篇 |
出版年
2024年 | 5篇 |
2023年 | 44篇 |
2022年 | 96篇 |
2021年 | 170篇 |
2020年 | 114篇 |
2019年 | 162篇 |
2018年 | 176篇 |
2017年 | 137篇 |
2016年 | 149篇 |
2015年 | 149篇 |
2014年 | 216篇 |
2013年 | 239篇 |
2012年 | 351篇 |
2011年 | 343篇 |
2010年 | 195篇 |
2009年 | 157篇 |
2008年 | 287篇 |
2007年 | 237篇 |
2006年 | 208篇 |
2005年 | 207篇 |
2004年 | 167篇 |
2003年 | 139篇 |
2002年 | 101篇 |
2001年 | 29篇 |
2000年 | 32篇 |
1999年 | 29篇 |
1998年 | 20篇 |
1997年 | 21篇 |
1996年 | 21篇 |
1995年 | 10篇 |
1994年 | 6篇 |
1993年 | 15篇 |
1992年 | 23篇 |
1991年 | 15篇 |
1990年 | 17篇 |
1988年 | 21篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 14篇 |
1984年 | 18篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1974年 | 5篇 |
1972年 | 12篇 |
1970年 | 5篇 |
1967年 | 6篇 |
排序方式: 共有4478条查询结果,搜索用时 46 毫秒
1.
Exhaled nitric oxide in children with allergic rhinitis: A potential biomarker of asthma development
下载免费PDF全文
![点击此处可从《Pediatric allergy and immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
Giorgio Gandaglia Guillaume Ploussard Massimo Valerio Agostino Mattei Cristian Fiori Nicola Fossati Armando Stabile Jean-Baptiste Beauval Bernard Malavaud Mathieu Roumiguié Daniele Robesti Paolo Dell’Oglio Marco Moschini Stefania Zamboni Arnas Rakauskas Francesco De Cobelli Francesco Porpiglia Francesco Montorsi Alberto Briganti 《European urology》2019,75(3):506-514
Background
Available models for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) might not be applicable to men diagnosed via magnetic resonance imaging (MRI)-targeted biopsies.Objective
To assess the accuracy of available tools to predict LNI and to develop a novel model for men diagnosed via MRI-targeted biopsies.Design, setting, and participants
A total of 497 patients diagnosed via MRI-targeted biopsies and treated with RP and extended pelvic lymph node dissection (ePLND) at five institutions were retrospectively identified.Outcome measurements and statistical analyses
Three available models predicting LNI were evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analyses. A nomogram predicting LNI was developed and internally validated.Results and limitations
Overall, 62 patients (12.5%) had LNI. The median number of nodes removed was 15. The AUC for the Briganti 2012, Briganti 2017, and MSKCC nomograms was 82%, 82%, and 81%, respectively, and their calibration characteristics were suboptimal. A model including PSA, clinical stage and maximum diameter of the index lesion on multiparametric MRI (mpMRI), grade group on targeted biopsy, and the presence of clinically significant PCa on concomitant systematic biopsy had an AUC of 86% and represented the basis for a coefficient-based nomogram. This tool exhibited a higher AUC and higher net benefit compared to available models developed using standard biopsies. Using a cutoff of 7%, 244 ePLNDs (57%) would be spared and a lower number of LNIs would be missed compared to available nomograms (1.6% vs 4.6% vs 4.5% vs 4.2% for the new nomogram vs Briganti 2012 vs Briganti 2017 vs MSKCC).Conclusions
Available models predicting LNI are characterized by suboptimal accuracy and clinical net benefit for patients diagnosed via MRI-targeted biopsies. A novel nomogram including mpMRI and MRI-targeted biopsy data should be used to identify candidates for ePLND in this setting.Patient summary
We developed the first nomogram to predict lymph node invasion (LNI) in prostate cancer patients diagnosed via magnetic resonance imaging-targeted biopsy undergoing radical prostatectomy. Adoption of this model to identify candidates for extended pelvic lymph node dissection could avoid up to 60% of these procedures at the cost of missing only 1.6% patients with LNI. 相似文献3.
Six patients who injured their wrists had radiographs documenting a dorsal, 5- to 10-mm oblong fragment of bone immediately proximal to the base of the fourth and/or fifth metacarpal bones. The fragment was seen on the pronation oblique and/or lateral projections, but not on the posteroanterior projection. The radiographic appearance of the fragment was remarkably similar in all cases. In the one patient in which it was performed, pluridirectional tomography demonstrated that the fragment originated from the dorsal surface of the hamate. Five of the six patients also had associated posterior dislocation of the fourth and/or fifth metacarpals. We conclude that this fragment represents a coronal fracture through the body of the hamate resulting from posterior dislocation or subluxation of the fourth and/or fifth metacarpal. 相似文献
4.
5.
G Salviati R Betto D Danieli-Betto E Biasia M Serena M Mini G Scarlato 《Neurology》1986,36(5):693-697
We evaluated the isoform composition of heavy and light chains of myosin in single muscle fibers from patients with Duchenne dystrophy, myotonic dystrophy, or polymyositis. In all myopathic muscles, there was an increase in the proportion of intermediate fibers which, by analysis of myosin isoforms, fell into two subpopulations, one that contained both fast and slow myosin and another that contained myosin molecular hybrids. The increased proportion of intermediate (or transitional) fibers suggests changes in the equilibrium between fast and slow motor units. These changes could result from regeneration and subsequent maturation of fibers or from direct transformation of mature fibers of one type into the opposite. 相似文献
6.
7.
目的评价β-受体阻滞剂治疗老年冠心病慢性心力衰竭的疗效及安全性。方法105例老年冠心病慢性心力衰竭患者按就诊顺序随机分为两组,美托洛尔组52例在常规抗心力衰竭治疗基础上加用美托洛尔12.5~25mg,2/d;对照组53例采用常规抗心力衰竭治疗,未用美托洛尔。定期来诊随访,观察临床表现,监测治疗前后心率、血压、心功能参数变化。结果美托洛尔组显效率53.8%,总有效率88.5%;对照组显效率30.2%,总有效率67.9%,两者比较有显著性差异(P〈0.05)。美托洛尔组患者心率减慢、血压降低较对照组明显,超声心动图复查显示治疗6个月后左室舒张末期内径缩小,左室射血分数增高较对照组显著。结论美托洛尔为老年冠心病慢性心力衰竭提供一种较为安全有效的药物治疗手段。 相似文献
8.
9.
10.
Mark R. Beauchamp Albert V. Carron Serena McCutcheon Oliver Harper 《Annals of behavioral medicine》2007,33(2):200-206
Background: A growing body of research suggests that older exercisers prefer to exercise alone rather than in group-based settings. One
limitation of these studies, however, has been that researchers have failed to take into account the age-related characteristics
of groups when asking adults about their preferences for exercise settings.Purpose: The overall purpose of this study was to examine the exercise preferences of 947 adults for involvement in standard exercise
classes populated by participants from various categories across the age spectrum.Results: The results revealed that when faced with the prospect of exercising with considerably older or younger exercisers, participants
found such an exercise context to be largely unappealing. However, in accordance with the basic tenets of self-categorization
theory, the results revealed that older and younger adults alike express a positive preference for exercising in standard
exercise classes comprised of similarly aged participants.Conclusions: The findings of this study challenge a growing call for exercise interventions for older adults to be primarily directed
at the individual-level, and suggest that group-related intervention strategies may indeed be attractive to older exercisers. 相似文献