排序方式: 共有16条查询结果,搜索用时 31 毫秒
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Joseph Meserve Satimai Aniwan Jenna L. Koliani-Pace Preeti Shashi Aaron Weiss David Faleck Adam Winters Shreva Chablaney Gursimran Kochhar Brigid S. Boland Siddharth Singh Robert Hirten Eugenia Shmidt Justin G. Hartke Prianka Chilukuri Matthew Bohm Sashidhar Varma Sagi Monika Fischer Parambir S. Dulai 《Clinical gastroenterology and hepatology》2019,17(8):1533-1540.e2
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Leeb A Wernsdorfer G Satimai W Wiedermann U Congpuong K Wernsdorfer WH 《Wiener klinische Wochenschrift》2010,122(Z3):61-65
The pharmacodynamic interaction between lumefantrine and monodesbutyl-benflumetol has been investigated in 44 fresh isolates of patients with a Plasmodium falciparum infection from the region of Mae Sot (Thailand). Both substances proved to be effective against parasite maturation within the test concentration range, with monodesbutyl-benflumetol being effective at a lower concentration than lumefantrine. Synergism between the two substances was evaluated with a combination of lumefantrine and monodesbutyl-benflumetol at a ratio of 4.25:1. The geometric mean values for complete inhibition of schizont maturation were 1035.7 nM for lumefantrine, 655 nM for monodesbutyl-benflumetol and 222.5 nM for the combination of both. An analysis for interaction according to the method of Berenbaum indicates a moderate synergism at the IC(50), which gets stronger with increasing ICs and reaches the highest level at the IC(99). The geometric mean of the sums of the FIC(50) is 0.73, of the FIC(90) it is 0.37 and of the FIC(99) it is 0.25. 相似文献
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Rogawski ET Congpuong K Sudathip P Satimai W Sug-aram R Aruncharus S Darakapong A Kitchakarn S Meshnick SR 《The American journal of tropical medicine and hygiene》2012,86(5):789-791
We conducted contact tracing and high-risk group screening using pooled real-time polymerase chain reaction (PCR) to support malaria elimination in Thailand. PCR detected more Plasmodium infections than the local and expert microscopists. High-throughput pooling technique reduced costs and allowed prompt reporting of results. 相似文献
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Joyce Wing Yan Mak Whitney Tang Terry Cheuk Fung Yip Zhi Hua Ran Shu Chen Wei Vineet Ahuja Sudheer Kumar Wai Keung Leung Ida Hilmi Julajak Limsrivilai Satimai Aniwan Belsy C. Y. Lam Kam Hon Chan Ka Man Ng Chi Man Leung Michael K. K. Li Fu Hang Lo Alex Shun Fung Sze Steven Woon Choy Tsang Aric J. Hui Juanda Leo Hartono Siew C. Ng 《Alimentary pharmacology & therapeutics》2019,50(11-12):1195-1203
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The Optimal Cut-Off Level of The Fecal Immunochemical Test For Colorectal Cancer Screening in a Country with Limited Colonoscopy Resources: A Multi-Center Study from Thailand
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Satimai AniwanThawee Ratanachu-EkSupot PongprasobchaiJulajak LimsrivilaiOng-Ard PraisontarangkulPises PisespongsaPisaln MairiangApichat SangchanJaksin SottisupornNaruemon WisedopasPinit KullavanijayaRungsun Rerknimitr 《Asian Pacific journal of cancer prevention》2017,18(2):405-412
Background: Selecting the cut-off point for the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening programs is of prime importance. The balance between the test performance for detecting advanced neoplasia and the available colonoscopy resources should be considered. We aimed to identify the optimal cut-off of FIT for advanced neoplasia in order to minimize colonoscopy burden. Methods: We conducted a multi-center study in 6 hospitals from diverse regions of Thailand. Asymptomatic participants, aged 50-75 years, were tested with one-time quantitative FIT (OC-SENSOR, Eiken Chemical Co.,Ltd., Tokyo, Japan) and all participants underwent colonoscopy. We assessed test performance in detecting advanced neoplasia (advanced adenoma and CRC) and measured the burden of colonoscopy with different cut-offs [25 (FIT25), 50 (FIT50), 100 (FIT100), 150 (FIT150), and 200 (FIT200)ng/ml]. Results: Among 1,479 participants, advanced neoplasia and CRC were found in 137 (9.3%) and 14 (0.9%), respectively. From FIT25 to FIT200, the positivity rate decreased from 18% to 4.9%. For advanced neoplasia, an increased cut-off decreased sensitivity from 42.3% to 16.8% but increased specificity from 84.2% to 96.3%. The increased cut-off increased the positive predictive value (PPV) from 21.5% to 31.5%. However, all cut-off points provided a high negative predictive value (NPV) (>90%). For CRC, the miss rate for FIT25 to FIT 150 was the same (n=3, 21%), whereas that with FIT200 increased to 35% (n=5). Conclusions: In a country with limited-colonoscopy resources, using FIT150 may be preferred because it offers both high PPV and NPV for advanced neoplasia detection. It could also decrease colonoscopy workload, while maintaining a CRC miss rate similar to those with lower cut-offs. 相似文献
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Satimai Aniwan W. Scott Harmsen William J. Tremaine Sunanda V. Kane Edward V. Loftus 《Mayo Clinic proceedings. Mayo Clinic》2018,93(10):1415-1422
Objective
To determine the mortality of Crohn disease (CD) and ulcerative colitis (UC) and temporal trends in mortality.Patients and Methods
All 895 residents of Olmsted County, Minnesota, first diagnosed as having inflammatory bowel disease (IBD) (411 with CD and 484 with UC) from January 1, 1970, through December 31, 2010, were followed through June 30, 2016. Standardized mortality ratios (SMRs) were computed—expected rates were derived from the US 2010 background population. To determine overall and cause-specific mortality, each patient with IBD was matched with 5 county residents, and Cox regression analysis was used to assess time to death.Results
A total of 895 patients with IBD and 4475 patients without IBD were included. Seventy-four patients with CD died compared with 59.2 expected (SMR, 1.25; 95% CI, 0.98-1.57), and 77 patients with UC died compared with 108.1 expected (SMR, 0.71; 95% CI, 0.56-0.89). In CD, the risk of dying was significantly associated with diagnosis from 1970 through 1979 (SMR, 1.90; 95% CI, 1.24-2.78). Of those diagnosed after 1980, the risk of dying in patients with CD was similar to the US background population. In UC, the risk of dying was less than expected in all periods of diagnosis. In the Cox regression analysis, overall mortality was not significantly higher in CD (hazard ratio [HR], 1.26; 95% CI, 0.97-1.63) or UC (HR, 0.89; 95% CI, 0.70-1.14) compared with the comparison cohort. The risk of dying of digestive diseases (HR, 3.70; 95% CI, 1.24-11.0) and respiratory diseases (HR, 2.72; 95% CI, 1.36-5.44) was increased in CD but not UC.Conclusion
In this cohort, overall mortality in patients with CD diagnosed after 1980 did not differ from that in the US background population. Overall mortality in patients with UC diagnosed from 1970 through 2010 was lower than the expected mortality. 相似文献10.
Audrey Lenhart Yuwadee Trongtokit Neal Alexander Chamnarn Apiwathnasorn Wichai Satimai Veerle Vanlerberghe Patrick Van der Stuyft Philip J. McCall 《The American journal of tropical medicine and hygiene》2013,88(2):254-259
The efficacy of insecticide-treated window curtains (ITCs) for dengue vector control was evaluated in Thailand in a cluster-randomized controlled trial. A total of 2,037 houses in 26 clusters was randomized to receive the intervention or act as control (no treatment). Entomological surveys measured Aedes infestations (Breteau index, house index, container index, and pupae per person index) and oviposition indices (mean numbers of eggs laid in oviposition traps) immediately before and after intervention, and at 3-month intervals over 12 months. There were no consistent statistically significant differences in entomological indices between intervention and control clusters, although oviposition indices were lower (P < 0.01) in ITC clusters during the wet season. It is possible that the open housing structures in the study reduced the likelihood of mosquitoes making contact with ITCs. ITCs deployed in a region where this house design is common may be unsuitable for dengue vector control. 相似文献