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Alexander Swidsinski Yvonne D?rffel Vera Loening-Baucke Alexander Tertychnyy Salbakay Biche-ool Sergei Stonogin Yi Guo Ning-Dong Sun 《Saudi Journal Of Gastroenterology》2012,18(1):55-58
Background/Aim:
To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis.Patients and Methods:
Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls.Results:
Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70–71% and in formalin-fixated material was 30–36%.Conclusions:
Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role. 相似文献2.
Svidzinskiĭ AV Tertychnyĭ AS Andreev AI Biche-ool SKh Mamchenko SI 《Arkhiv patologii》2010,72(5):44-46
The use of current diagnostic methods in a pathologist's practice, including the assessment of the bacterial microflora by the molecular microbiological technique fluorescence in situ hybridization is important and promising. The detection of bacteria and changes in the microbial flora makes it possible to clarify the nature of found morphological changes and to expand the diagnostic value of a postmortem study. 相似文献
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